A5052986901- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- Aldose Reductase and Taurine
- Uterine Myomas and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Endometrial and Cervical Cancer Treatments
- PARP inhibition in cancer therapy
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Retinoids in leukemia and cellular processes
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Toxin Mechanisms and Immunotoxins
- Management of metastatic bone disease
- Circular RNAs in diseases
- Cervical Cancer and HPV Research
- Heat shock proteins research
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Gynecological conditions and treatments
- BRCA gene mutations in cancer
Yamaguchi University
2014-2024
Kyushu University Hospital
2023
Tottori University
2023
The Cancer Institute Hospital
2014
To investigate whether long noncoding RNAs (lncRNAs) are involved in the development or malignant behavior of ovarian high-grade serous carcinoma (HGSC), we attempted to identify lncRNAs specific HGSC.
Abstract Somatic mutations in Mediator complex subunit 12 (MED12m) have been reported as a biomarker of uterine fibroids (UFs). However, the role MED12m is still unclear pathogenesis UFs. Therefore, we investigated differences DNA methylome, transcriptome, and histological features between MED12m-positive -negative methylomes transcriptomes were obtained from UFs myometrium, hierarchically clustered. Differentially expressed genes comparison with myometrium co-expressed detected by weighted...
Abstract Aim Heat shock protein 70 ( HSP70 ) was previously found to be highly expressed in cervical squamous cell carcinoma SCC tissues compared with normal by proteomic analyses. The present study investigated the roles of malignant behaviors and chemosensitivity cisplatin cells vitro . Methods Effects knockdown on activities migration, invasion proliferation, cycle status, apoptosis were examined using siRNA two human cancer SiHa SKG II ). Furthermore, effect apoptotic examined. Results...
Abstract Purpose : Proteomic profiling of human uterine cervical squamous cell carcinoma (SCC) tissues was performed to find new biomarkers for the early diagnosis and molecular target therapies. Experimental design Proteins extracted from five normal SCC were subjected 2‐DE followed by LC‐MS/MS. Results Twenty‐seven protein spots increased, them identified LC‐MS/MS be cytokeratin‐19, HSP70, HSP27, glyceraldehyde‐3‐phosphate dehydrogenase, transgellin‐2. The upregulation transgelin‐2...
The purpose of this study was to analyze the prognosis for endometrial cancer patients treated with systematic pelvic and para-aortic lymphadenectomy (PLA PALA) followed by platinum-based chemotherapy.From 1994 2004, in Cancer Institute Hospital, 502 who were surgically PLA PALA enrolled study. Their clinicopathological features retrospectively reviewed.One hundred ninety-one (38.0%) received adjuvant chemotherapy. Lymph node (LN) metastasis observed 80 (15.9%) patients, pelvic-only LN 27...
Carbonyl reductase 1 (CBR1) has been reported to be involved in cancer progression. Recently, we found that CBR1 overexpression inhibited malignant behaviors and the epithelial mesenchymal transition (EMT) uterine cervical cancer. It remained unclear whether this was also case leiomyosarcoma (uLMS), which is derived from cells a much more gynecological tumor. A number of previous studies suggested are associated with EMT, even tumors. In present study, investigated inhibits EMT uLMS. We...
Abstract Purpose Carbonyl reductase 1 ( CBR 1) is involved in cancer progression. Recently, the authors reported that loss of expression associated with a poor prognosis uterine cervical cancer. Here, we investigated whether decreased promotes progression by inducing epithelial mesenchymal transition EMT ). Methods Antisense constructs complementary DNA (antisense clones) and empty vectors (control were transfected into human squamous cell carcinoma lines SKG II SiHa) proliferation marker...
Squamous cell carcinoma antigen (SCCA) is clinically used as a tumor marker for patients with squamous of various organs. SCCA1 and its highly homologous molecule, SCCA2, belong to the serine proteinase inhibitors (serpins) family, suggesting that these proteins may be involved in malignant behavior cells. The aim this study functionally characterize tumor-associated serpins regarding potential influence production matrix metalloproteinases (MMPs), which play key role invasion metastasis....
Decreased expression of human leukocyte antigen (HLA) class I molecules, which is found in several types cancer, associated with worse clinical prognosis cancer patients. The present study was undertaken to investigate the association immunohistochemical HLA patterns clinicopathological factors and 96 endometrial composed a heavy chain (HC-10) β2-microglobulin (β2-m) light chain. were classified as positive when both HC-10 β2-m strongly stained negative all other cases. staining pattern...
To investigate whether maintenance treatment could be safely and effectively performed with olaparib, olaparib plus bevacizumab niraparib in platinum-sensitive advanced ovarian cancer at multiple institutions Japan.
Dose-dense paclitaxel /carboplatin (ddTC) therapy was shown to be more effective against ovarian cancer than conventional tri-weekly TC in the JGOG3016 study. However, two phase III studies performed after did not show same positive results. Because we have been using ddTC frontline or first platinum-sensitive relapse of cancer, investigated clinical outcome patients treated with ddTC.
Abstract The aim of this study was to detect the cleaved form serine proteinase inhibitor (serpin), squamous cell carcinoma (SCC) antigen‐1 in normal and malignant epithelial tissues, which implies presence its target proteinase. SCC epithelium identified as a single spot with p I 6.35 M r 40 000 by two‐dimensional electrophoresis (2‐DE) combined immunoblotting. Interestingly, showed different biochemical properties heat stability or immunoreactivity monoclonal antibody for antigen (Mab 426)...
Abstract Aim Transgelin‐2 (TAGLN2) has previously been found to be highly expressed in uterine cervical squamous cell carcinoma (SCC) tissues by proteomic analyses. The present study investigated the role of TAGLN2 malignant behaviors SCC cells vitro and vivo , clinical significance using immunohistochemistry for human tissues. Methods Antisense (AS) constructs cDNA (AS clones) empty vector (control clone) were transfected into a line (SKG IIIa), analyzed . In an experiment, 10 7 AS control...
Abstract Purpose To identify the aberrantly expressed long non‐coding RNAs (lncRNAs) in ovarian high‐grade serous carcinoma (HGSC). Methods Total RNA was isolated HGSC cell lines, surface epithelial cells, and normal ovaries. Aberrantly lncRNAs were identified by PCR array, which analyzes 84 kinds of lncRNAs. infer their functions, lines with different levels expression established, then, activities proliferation, migration, apoptosis examined. Expression also examined multiple tissues....
Background/Aim: To determine if maintenance treatment can be performed effectively and safely in patients with platinum-sensitive relapsed ovarian cancer. Patients Methods: We carried out a multi-center study to investigate progression-free survival (PFS) adverse events (AEs) 229 receiving for Results: The median PFS the was 14.0 months (95% confidence interval=10.3-17.6 months). hematological toxicities included ≥grade 3 anemia 33.2% of cases. Anemia during significantly more common than...