A5102767200- Liver Disease Diagnosis and Treatment
- Peripheral Artery Disease Management
- Liver physiology and pathology
- Hepatitis C virus research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- T-cell and Retrovirus Studies
- Cardiac Imaging and Diagnostics
- Glycosylation and Glycoproteins Research
- Coronary Interventions and Diagnostics
- Cardiovascular Disease and Adiposity
- Immunotherapy and Immune Responses
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Function and Risk Factors
- Hepatocellular Carcinoma Treatment and Prognosis
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis B Virus Studies
- Uterine Myomas and Treatments
- Polyamine Metabolism and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Endoplasmic Reticulum Stress and Disease
- Galectins and Cancer Biology
- Cell Adhesion Molecules Research
- Acute Myocardial Infarction Research
Yamaguchi University
2021-2025
Nara Institute of Science and Technology
2023-2024
Japanese Red Cross Society, Japan
2012-2024
Tottori University
2023
Kyushu University Hospital
2023
Tokyo Institute of Technology
2018-2023
Community Link
2023
Kumamoto Medical Center
2023
Shinshu University
2014-2022
Shinshu University Hospital
2019-2022
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Properties of the Products Reaction Tadpole Collagenase with Collagen*Takahiro Sakai and Jerome GrossCite this: Biochemistry 1967, 6, 2, 518–528Publication Date (Print):February 1, 1967Publication History Published online1 May 2002Published inissue 1 February 1967https://pubs.acs.org/doi/10.1021/bi00854a021https://doi.org/10.1021/bi00854a021research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations197LEARN...
In patients with hepatocellular carcinoma (HCC), recurrences in the distant liver often are observed after curative treatment. Microwave coagulation therapy (MCT) and radiofrequency ablation (RFA) have been developed as less invasive alternatives than surgical resection for small HCCs. current study, risk factors recurrence of HCC were analyzed whom complete was achieved.Ninety-two HCCs < 3 cm greatest dimension treated by MCT or RFA percutaneously laparoscopically. Eighty-four achieved...
Consomic strains, also known as chromosome substitution are powerful tools for assigning polygenes that control quantitative complex traits to specific chromosomes. Here, we report generation of a full set mouse consomic in which each the common laboratory strain C57BL/6J (B6) is replaced by its counterpart from inbred MSM/Ms, derived Japanese wild mouse, Mus musculus molossinus . The genome sequence MSM/Ms divergent B6, whose predominantly Western European domesticus exhibits number...
To investigate whether long noncoding RNAs (lncRNAs) are involved in the development or malignant behavior of ovarian high-grade serous carcinoma (HGSC), we attempted to identify lncRNAs specific HGSC.
Abstract Purpose Uterine leiomyomas (ULMs) are classified into those with and without MED12 mutations (MED12m(+) MED12m(−), respectively). This study was undertaken to establish a culture system evaluate the effect of female hormones on growth ULM cells in each subtype. Methods isolated from MED12m(+) or MED12m(−) tissues were cultured monolayer for 7 days four hormone treatments: estrogen (E) progesterone (P) (E + P), E only (E), P (P), medium (CTRL). They also 3D spheroid above treatments...
Purpose: Geriatric nutritional related index (GNRI) is a simple and well-established screening method of status. We aimed to develop validate scoring system including GNRI predict long-term outcomes in patients with chronic limb-threatening ischemia (CLTI) undergoing endovascular treatment (EVT). Materials methods: Patients EVT for symptomatic LEAD from August 2015 2016 were enrolled into the I-PAD NAGANO registry, prospective, multicenter, observational registry. identified predictors...
Background —Laminin receptors are involved in cell-extracellular matrix interactions malignant cells that show invasion and metastasis. Hepatocellular carcinoma frequently shows early into blood vessels, intrahepatic extrahepatic metastases. However, the role of laminin hepatocellular is unknown. Aims —To examine expression mRNA for their isoforms carcinoma. Methods —The several receptors, including α1 integrin, α6 integrin its α6A α6B, β1 β1A β1B, 32kD/67kDa binding protein was examined...
The efficacy and safety of peginterferon alpha-2a (40 KD) (peg-IFNalpha-2a) plus ribavirin has not been reported for Japanese patients with chronic hepatitis C. aim this study was to evaluate combination in treatment-naïve non-responders or relapsers interferon monotherapy.Overall, 201 C virus (HCV) genotype-1b were randomly assigned 180 microg peg-IFNalpha-2a once-weekly 600-1000 mg/day placebo 48 weeks. Additionally, administered weeks 100 (85% genotype-1) previous monotherapy.A sustained...
Abstract Somatic mutations in Mediator complex subunit 12 (MED12m) have been reported as a biomarker of uterine fibroids (UFs). However, the role MED12m is still unclear pathogenesis UFs. Therefore, we investigated differences DNA methylome, transcriptome, and histological features between MED12m-positive -negative methylomes transcriptomes were obtained from UFs myometrium, hierarchically clustered. Differentially expressed genes comparison with myometrium co-expressed detected by weighted...
beta 1-integrin modulates cellular phenotype by mediating signals from the extracellular matrix (ECM). Although overexpression of integrin molecules in hepatocellular carcinoma (HCC) has been reported, role overexpressed disease process HCC is not fully understood. The authors investigated effects on apoptosis hepatoma cells.Human cell lines HepG2, Huh7, and HLE were stably transfected with full-length 1-integrin. Cells underwent induced chemotherapeutic reagents, including cis-platinum...
Although the causal agent of yellows Brassica rapa (turnip, pak choi, and narinosa) in Japan was reported 1996 to be Fusarium oxysporum f. sp. conglutinans, this classification has remained inconclusive because a lack detailed genetic pathogenic studies. Therefore, we analyzed taxonomic position organism using Japanese isolates F. complex obtained from diseased individuals various B. subspecies. Phylogenetic analyses partial sequences rDNA intergenic spacer region mating-type gene...
Three different types of coordination polymers, one-dimensional (1D) straight chain, 1D-columnar structure, and two-dimensional (2D) layer have been prepared by the complexation Ag(I) ions with bis(pyridyl) ligands linked an aromatic sulfonamides structurally characterized single-crystal X-ray diffraction thermogravimetric analysis. Structural analyses showed that 3-pyridyl ligand AgOTf 4-pyridyl AgBF4 in CHCl3/CH3CN resulted formation 1D straight-chain polymers. In CHCl3/CH3CN, resulting...
Microchiroptera have diversified into many species whose size and the shapes of complicated ear nose been adapted to their echolocation abilities. Their speciation processes, intra- interspecies relationships are still under discussion. Here we report on geographical variation Japanese Rhinolophus ferrumequinum R. cornutus using complete sequence mitochondrial cytochrome b gene clarify phylogenetic positions 2 as well that Rhinolophidae within Microchiroptera. We found divergence values each...
Growth factors and extracellular matrices cooperatively regulate cellular behavior. However, the interactions between transforming growth factor‐β1 (TGF‐β1) integrins in hepatic cells are not fully understood. We investigated effects of β1‐integrin on TGF‐β1‐regulated hepatoma cells. Human cell lines HepG2, Huh7, Hep3B were stably transfected with β1‐integrin, parental, mock‐ β1‐integrin‐transfected treated TGF‐β1. Modulation apoptosis pathways involved process investigated. TGF‐β1...
An asymmetric Strecker-type reaction of nitrones using acetone cyanohydrin as a source HCN has been realized. A magnesium–tartramide complex, generated from (R,R)-2,3-dihydroxy-1,4-di(pyrrolidin-1-yl)-butane-1,4-dione and MeMgBr, promoted transcyanation the bromomagnesium salt cyanohydrin, in presence catalytic amount DBU, to afford corresponding optically active (S)-α-amino nitrile derivatives. The was applicable various giving high-to-excellent enantioselectivities.