A5089656980- Intracranial Aneurysms: Treatment and Complications
- Gastric Cancer Management and Outcomes
- Moyamoya disease diagnosis and treatment
- Eosinophilic Esophagitis
- Cerebrovascular and Carotid Artery Diseases
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Gastroesophageal reflux and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Metastasis and carcinoma case studies
- Vascular Malformations Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Cerebrovascular and genetic disorders
- Neurological Complications and Syndromes
- Neurosurgical Procedures and Complications
- Amino Acid Enzymes and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Liver Disease and Transplantation
- Acute Ischemic Stroke Management
- Polyamine Metabolism and Applications
- Abdominal vascular conditions and treatments
Kohnan Hospital
2015-2025
Hitachi (Japan)
2023
Kobe City Medical Center West Hospital
2023
National Hospital Organization
2021-2022
Sendai Medical Center
2020-2022
Nippon Medical School Hospital
2020
Tohoku University
2007-2020
Himeji Red Cross Hospital
2019
Hyogo Medical University
2013-2017
Saga Medical School Hospital
2005-2016
Transplantation of neural stem cells (NSCs) offers a novel therapeutic strategy for stroke; however, massive grafted cell death following transplantation, possibly due to hostile host brain environment, lessens the effectiveness this approach. Here, we have investigated whether reprogramming NSCs with minocycline, broadly used antibiotic also known possess cytoprotective properties, enhances survival and promotes neuroprotection in ischemic stroke. harvested from subventricular zone fetal...
Hemoglobin (Hb) released from extravasated erythrocytes is implicated in brain edema after intracerebral hemorrhage (ICH). a major component of blood and potent mediator oxidative stress ICH. Oxidative matrix metalloproteinases (MMPs) are associated with blood–brain barrier (BBB) dysfunction. This study was designed to elucidate whether Hb-induced contributes MMP-9 activation BBB dysfunction vivo. An injection Hb into rat striata induced increased hydroethidine (HEt) signals parallel levels....
Muse cells reside as pre-existing pluripotent-like stem within the fibroblasts, are nontumorigenic, exhibit differentiation capacity into triploblastic-lineage cells, and replenish lost when transplanted in injury models. Cell fate function of human skin fibroblast-derived were evaluated a rat stroke model.Muse (30,000), collected by pluripotent surface marker stage-specific embryonic antigen-3, injected stereotaxically three deposits ischemic cortex at 2 days after transient middle cerebral...
Transplantation of neural stem cells provides a promising therapy for stroke. Its efficacy, however, might be limited because massive grafted-cell death after transplantation, and its insufficient capability tissue repair. Interleukin 6 is pro-inflammatory cytokine involved in the pathogenesis various neurological disorders. Paradoxically, interleukin promotes pro-survival signalling pathway through activation signal transducer activator transcription 3. In this study, we investigated...
Medium spiny neurons (MSNs) constitute most of the striatal and are known to be vulnerable ischemia; however, mechanisms vulnerability remain unclear. Activated forms nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase (NOX), which require interaction between cytosolic membrane-bound subunits, among major sources superoxide in central nervous system. Although increasing evidence suggests that NOX has important roles neurodegenerative diseases, its MSN injury after transient global...
<b><i>Background:</i></b> This retrospective study aimed to determine risk factors associated with serious complications of endoscopic submucosal dissection gastric tumors in multicenters compared between high- and low-volume centers. <b><i>Methods:</i></b> Between 2001 2010, was performed 1,190 lesions 1,082 patients five hospitals Saga, three high-volume two Risk for were evaluated. Patients’ background characteristics evaluated, including...
Background and Purpose— The harsh host brain microenvironment caused by production of reactive oxygen species after ischemic reperfusion injury offers a significant challenge to survival transplanted neural stem cells (NSCs) stroke. Copper/zinc-superoxide dismutase (SOD1) is specific antioxidant enzyme that counteracts superoxide anions. We have investigated whether genetic manipulation overexpress SOD1 enhances grafted accelerates amelioration Methods— NSCs genetically modified or...
Previous studies have shown that intraparenchymal transplantation of neural stem cells ameliorates neurological deficits in animals with intracerebral hemorrhage. However, hemoglobin the host brain environment causes massive grafted cell death and reduces effectiveness this approach. Several preconditioning induced by sublethal hypoxia can markedly improve tolerance treated subjects to more severe insults. Therefore, we investigated whether hypoxic enhances resilience hemorrhagic stroke...
Introduction: Moyamoya disease (MMD) is a cerebrovascular characterized by progressive steno-occlusive lesions in the terminal portion of internal carotid artery. Despite its unknown etiology, immune dysregulation regarded as critical trigger for delineating pathophysiology MMD. The gut microbiota produces short-chain fatty (SCFA) and organic acids, influencing regulation vascular remodeling. We aimed to characterize patients with Methods: Sixteen MMD sixteen healthy controls were included...
Diverticular bleeding is a common cause of lower gastrointestinal hemorrhage. Several factors, including use non-steroidal anti-inflammatory drugs (NSAIDs), antithrombotic agents and arteriosclerosis, could be risk factors. The aim this study to identify these factors.Between January 2000 December 2008, 51 patients among 178 acute hemorrhages who visited Saga Medical School were diagnosed as colonic diverticular hemorrhage, established by emergency endoscopy diagnostic criteria. Gender age...
A reproducible transient global cerebral ischemia (tGCI) mouse model has not been fully established. Although striatal neurons and white matter are recognized to be vulnerable ischemia, their injury after tGCI in mice elucidated. The purpose of this study was evaluate injuries C57BL/6 mice, develop a model. Male were subjected by bilateral common carotid artery occlusion (BCCAO). Mice whose cortical blood flow BCCAO decreased less than 13% the pre-ischemic value used. Histological analysis...