A5080234022- Immune cells in cancer
- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- CRISPR and Genetic Engineering
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Fish Biology and Ecology Studies
- Renal and related cancers
- Fish Ecology and Management Studies
- Cancer, Lipids, and Metabolism
- Hormonal Regulation and Hypertension
- Antibiotics Pharmacokinetics and Efficacy
- Viral-associated cancers and disorders
- Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- T-cell and B-cell Immunology
- Estrogen and related hormone effects
The University of Texas MD Anderson Cancer Center
2023-2025
Kyoto University
2013-2024
Shizuoka General Hospital
2023
Oita University
2023
Institute of Social and Preventive Medicine
2023
University of Bern
2023
Creative Commons
2023
Kyoto University Hospital
2020
Kindai University
2018-2020
Enoshima Aquarium
1967-1976
Abstract Homologous recombination repair (HRR) pathway deficiency (HRD) is involved in the tumorigenesis and progression of high-grade serous ovarian carcinoma (HGSOC) as well sensitivity to platinum chemotherapy drugs. In this study, we obtained data from The Cancer Genome Atlas (TCGA) on HGSOC identified scores for loss heterozygosity, telomeric allelic imbalance, large-scale state transitions, calculated HRD score. We then investigated relationships among score, genetic/epigenetic...
Tertiary lymphoid structures (TLS) are transient ectopic aggregates whose formation might be caused by chronic inflammation states, such as cancer. However, how TLS induced in the tumor microenvironment (TME) and they affect patient survival not well understood. We investigated distribution relation to infiltrating lymphocytes (TILs) related gene expression high-grade serous ovarian cancer (HGSC) specimens. CXCL13 correlated with presence infiltration of T cells B cells, it was a favorable...
Abstract New approaches beyond PD-1/PD-L1 inhibition are required to target the immunologically diverse tumor microenvironment (TME) in high-grade serous ovarian cancer (HGSOC). In this study, we explored immunosuppressive effect of B7-H3 (CD276) via CCL2–CCR2–M2 macrophage axis and its potential as a therapeutic target. Transcriptome analysis revealed that is highly expressed PD-L1–low, nonimmunoreactive HGSOC tumors, expression negatively correlated with an IFNγ signature, which reflects...
Abstract While large publicly available cancer cell line databases are invaluable for preclinical drug discovery and biomarker development, the association between homologous recombination deficiency (HRD) sensitivity in these resources remains unclear. In this study, we comprehensively analyzed molecular profiles screening data from Cancer Cell Line Encyclopedia. Unexpectedly, gene alterations BRCA1/2 or recombination-related genes, HRD scores, mutational signature 3 were not positively...
PURPOSE Homologous recombination DNA repair deficiency (HRD) is associated with sensitivity to platinum and poly (ADP-ribose) polymerase inhibitors in certain cancer types, including breast, ovarian, pancreatic, prostate. In these cancers, BRCA1/ 2 alterations genomic scar signatures are useful indicators for assessing HRD. However, other homologous (HRR)-related genes their clinical significance types have not been adequately systematically investigated. METHODS We obtained data sets of all...
Immunotherapy has experienced remarkable growth recently. Tertiary lymphoid structures (TLSs) and B cells may play a key role in the immune response have survival benefit some solid tumors, but there been no reports about their endometrial cancer (EC). We investigated clinicopathological pathobiological characteristics of tumor microenvironment (TME) EC. Patients with EC at Kyoto University Hospital during 2006-2011 were retrospectively included. In 104 patients who met study inclusion...
Although bevacizumab has been used in the treatment of ovarian cancer, its optimal use is unknown.To investigate time-dependent changes outcomes therapy.This cohort study was conducted using published data from 7 previous randomized phase 3 clinical trials with (ICON7, GOG-0218, BOOST, GOG-0213, OCEANS, AURERIA, and MITO16B) January 10 to 31, 2023. From 2 ancillary analyses ICON7 trial individual patient tumor gene expression profiles, an ICON7-A generated comprising 745 cases. other...
<p>Supplementary Figures and Supplementary Figure Legends</p>
<div>Abstract<p>Adult type ovarian granulosa cell tumors (AGCT) are rare malignancies with the near universal c.C402G (p.Cys134Trp) somatic mutation in <i>FOXL2</i>, a forkhead box family transcription factor important for function. Relapsed AGCT is incurable, but mechanism of unique <i>FOXL2</i> could confer therapeutic vulnerabilities. To identify FOXL2<sup>C134W</sup>-dependent pharmacologic synergies, we created and characterized endogenous...
Abstract Background: High-grade serous ovarian carcinoma (HGSOC) is driven by chromosomal instability and patterns of genomic rearrangement have predictive prognostic value in this disease. Nearly all next generation sequencing performed to date rely on short read sequencing, which unable resolve complex rearrangements or analyze repetitive centromeric telomeric regions. Here we combine long-read (LRS) platform with the recently completed telomere-to-telomere (T2T-CHM13) reference genome...
Ovarian clear cell carcinoma (OCCC), which has unique clinical characteristics, arises from benign endometriotic cysts, forming an oxidative stress environment because of excess iron accumulation, and exhibits poor prognosis, particularly in advanced stages owing to resistance conventional therapeutics. Ferroptosis is iron-dependent form programmed death induced by lipid peroxidation controlled Hippo signaling. We hypothesized that overcoming ferroptosis attractive strategy OCCC acquires...
Abstract The Cancer Genome Atlas (TCGA) network has clarified that ~50% of high‐grade serous ovarian cancers show homologous recombination deficiency (HRD). However, the frequency HRD in Japanese patients with cancer remains unclear. We aimed to identify HR‐associated gene mutations cancer. JGOG3025 study is a multicenter collaborative prospective observational involving 65 sites throughout Japan. recruited 996 who were clinically diagnosed before surgery from March 2017 2019, and 701...
Homologous recombination DNA repair deficiency (HRD) is associated with sensitivity to platinum and poly (ADP-ribose) polymerase inhibitors in certain cancer types, including breast, ovarian, pancreatic, prostate. In these cancers,
Serous carcinoma of the uterus (USC) is a pathological subtype high-grade endometrial cancers, with no effective treatment for advanced cases. Since such refractory tumors frequently harbor antitumor immune tolerance, many immunotherapies have been investigated various malignant using immuno-competent animal models mimicking their local immunities. In this study, we established an orthotopic mouse model cancer and evaluated tumor immunity to explore efficacy against USC. A multivariate...
Abstract Humoral hypercalcemia of malignancy ( HHM ) is a paraneoplastic syndrome primarily caused by tumor‐producing parathyroid hormone‐related protein PTH ‐ rP ). We describe the first reported case uterine carcinosarcoma causing . A 70‐year‐old patient was transferred to our hospital for tumor accompanied impaired consciousness. The laboratory tests indicated anemia, malnutrition, elevated serum calcium and Emergency surgery, including abdominal hysterectomy bilateral...
Abstract The in vitro growth (IVG) of human follicles is a potential fertility option for women whom cryopreserved ovarian tissues cannot be transplanted due to the risk cancer cell reintroduction; however, there currently no established method. Furthermore, optimal IVG conditions may differ between adult and pre-pubertal females molecular differences suggested by basic research. To systematically identify secondary females, comparative transcriptomic study using mice was conducted herein....
Background In cancer therapy, higher-resolution tumor-agnostic biomarkers that predict response to immune checkpoint inhibitor (ICI) therapy are needed. Mutation signatures reflect underlying oncogenic processes can affect tumor immunogenicity, and thus potentially delineate ICI treatment among types. Methods Based on mutational signature analysis, we developed a stratification for all solid tumors in The Cancer Genome Atlas (TCGA). Subsequently, new software (Genomic Subtyping Predictive...
Abstract Background Genomic alterations in BRCA1/2 and genomic scar signatures are associated with homologous recombination DNA repair deficiency (HRD) serve as therapeutic biomarkers for platinum PARP inhibitors breast ovarian cancers. However, the clinical significance of these other repair-related genes or cancer types is not fully understood. Results We analyzed datasets all solid cancers from The Cancer Genome Atlas Cell Line Encyclopedia, found that association between biallelic...