A5085436309- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Peroxisome Proliferator-Activated Receptors
- Metabolism and Genetic Disorders
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Cancer-related molecular mechanisms research
- Barrier Structure and Function Studies
- Gastrointestinal Tumor Research and Treatment
- Sarcoma Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Prenatal Screening and Diagnostics
- Intraperitoneal and Appendiceal Malignancies
- Genomic variations and chromosomal abnormalities
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Cancer Cells and Metastasis
- Bacterial Genetics and Biotechnology
- Psoriasis: Treatment and Pathogenesis
- Reproductive Biology and Fertility
- Bacteriophages and microbial interactions
- Cancer Diagnosis and Treatment
Fukushima Medical University
2015-2024
Waseda University
2024
Fukushima Medical University Hospital
2020-2021
Tokyo Medical University
2013-2020
Weatherford College
2020
Kagawa Prefectural Central Hospital
2020
Tokyo Medical University Hachioji Medical Center
2017
Tokyo Medical University Hospital
2017
Kanagawa Prefectural Hospital Organization
2011
Kanagawa Cancer Center
2011
Patient-derived tumor xenograft models represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture; however, their use is low-throughput and costly. To overcome this limitation, patient-derived organoids (PDOs) were established from human lung, ovarian uterine tissues, among others, to accurately efficiently recapitulate the tissue architecture function. PDOs able be cultured for >6 months, formed clusters similar morphologies source...
Among the claudin (CLDN) family, CLDN6 exhibits aberrant expression in various cancers, but its biological relevance has not yet been established. We generated a monoclonal antibody (mAb) against human and verified specificity. By immunohistochemical staining semi-quantification, we evaluated relationship between clinicopathological parameters tissues from 173 cases of endometrial cancer.The established mAb selectively recognized protein. Ten (5.8%) showed high (score 3+), whereas 19...
Abstract Cell adhesion proteins not only maintain tissue integrity, but also possess signaling abilities to organize diverse cellular events in a variety of physiologic and pathologic processes; however, the underlying mechanism remains obscure. Among cell molecules, claudin (CLDN) family is often aberrantly expressed various cancers, biological relevance molecular basis for this observation have yet been established. Here, we show that high CLDN6 expression accelerates proliferation...
Preoperative chemoradiotherapy has been shown to improve the outcome of patients with esophageal cancer, but because response this therapy varies, it is desirable identify in advance individuals who would be unlikely benefit, order avoid unnecessary adverse drug effects. The serum profiles 84 cytokines and related proteins were determined 37 squamous cell carcinoma received identical neoadjuvant preoperative regimens underwent surgical resection. Histological was assessed surgically resected...
A crucial step in the metastatic spread of ovarian cancer (OC) is adhesion and implantation tumor cells to peritoneal mesothelium. In order study this cascade, we derived a pro-metastatic human carcinoma cell line (MFOC3) from non-metastatic FOC3 line. Molecular profiling isogeneic lines identified differentially expressed genes, investigation for role dissemination specific factors was achieved by development co-culture assay utilizing monolayers mesothelial cells. After murine...
Endometrial carcinoma (EC) is a clinically heterogeneous disease characterized by number of different histological subtypes, and its heterogeneity may be involved in the accumulation multiple genetic alterations. The aim this work was to investigate comprehensive mutational profile EC tumors, examine associations between somatic mutations clinicopathological features or survival patients. A total 100 surgical tumors were obtained from patients who had previously undergone surgery. Genomic...
The tight‑junction protein claudin‑9 (CLDN9) is barely distributed in normal adult tissues but ectopically expressed various cancer types. Although multiple databases indicated upregulation of CLDN9 endometrial cancers at the mRNA level, its expression and biological roles remain obscure. In present study, prognostic significance was evaluated by immunohistochemical staining semi‑quantification using formalin‑fixed paraffin‑embedded specimens obtained from 248 carcinoma cases. A total 43...
We demonstrated in vitro that YycG-YycF of Bacillus subtilis constitutes a two-component system and shows specificity the sensor protein for cognate phosphorylation partner. Based on inhibition such an autophosphorylation YycG, we searched imidazole zerumbone derivatives to identify antibacterial agents as NH125, NH126, NH127, NH0891.
Several clinical trials have compared chemotherapy alone and chemoradiotherapy (CRT) for locally advanced pancreatic cancer (LAPC) treatment. However, predictive biomarkers optimal therapy of LAPC remain to be identified. We retrospectively estimated amplification the ACTN4 gene determine its usefulness as a biomarker LAPC. The copy number in 91 biopsy specimens before treatment was evaluated using fluorescence situ hybridisation (FISH). There were no statistically significant differences...
Accumulating evidences indicate that cyclooxygenase (COX)-2 plays an important role in tumorigenesis many human cancers. Yet the relationship between COX-2 and renal cell carcinoma (RCC) remains unclear. The aim of our study was to evaluate expression RCC lines its RCC. Among (SMKT-R4, OS-RC-2, ACHN) normal line RPTEC, overexpression found OS-RC-2 cells both at mRNA protein levels. sense- antisense-orientated vectors were constructed transferred into cells. Significant suppression cellular...
Poor nutritional status is common in ovarian cancer. It well known that the of a patient with malignant disease associated survival, and it can be assessed by serum levels rapid turnover proteins (RTPs), such as retinol binding protein, prealbumin transferrin. Systemic inflammation, usually observed form elevated C‑reactive protein (CRP) or neutrophil/lymphocyte ratio (NLR), occurs various mechanisms involving numerous pro‑inflammatory cytokines. These include interleukin (IL)‑17 other...
Background/Aims: Recently, postendoscopic submucosal dissection electrocoagulation syndrome (PEECS) has attracted attention. However, the criteria for computed tomography (CT) scanning following esophageal endoscopic (ESD) are unclear. In this study, we aimed to identify predictive factors of PEECS and usefulness CT after ESD. Methods: A total 245 lesions in 223 patients who underwent ESD between February 2008 October 2018 were retrospectively analyzed. Patients with double cancers, those...
Abstract The epidermal growth factor (EGF) receptor has been suggested to have an important role in tumor initiation and progression of human bladder cancers. Grb2 protein, which is the downstream effector EGF receptor, acts as adaptor protein between Ras guanine‐nucleotide exchange factor, son sevenless (Sos) protein. Sos regulates action by promoting GDP for GTP . However, significance proteins, related EGF‐triggered activation, not elucidated cancer. aim present study clarify these...