A5049820141- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Microbial Natural Products and Biosynthesis
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Quinazolinone synthesis and applications
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Enzyme Production and Characterization
- Synthesis and Biological Evaluation
- Proteoglycans and glycosaminoglycans research
- Cancer therapeutics and mechanisms
- Plant-derived Lignans Synthesis and Bioactivity
- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- Chemical Synthesis and Reactions
- Marine Sponges and Natural Products
- Pharmacogenetics and Drug Metabolism
- Synthesis of Organic Compounds
- Antimicrobial Peptides and Activities
- Biological Activity of Diterpenoids and Biflavonoids
- RNA and protein synthesis mechanisms
- Organometallic Complex Synthesis and Catalysis
- Inorganic and Organometallic Chemistry
Ohu University
2022-2025
Mitsubishi Gas Chemical (Japan)
2021-2025
Microbial Chemistry Research Foundation
2009-2024
Yasuda Women's University
2012-2022
University of California, Irvine
2017
Ajinomoto (Japan)
2014
Suzuki (Japan)
2014
Tohoku University
2004-2013
Kyushu University
2006-2013
Toyama Prefectural University
2013
Here we introduce silyl ether linkage as a novel dynamic covalent motif for material design. Through introduction of neighboring amino moiety, show that the exchange rate can be accelerated by almost three orders magnitude. By incorporating such linkages into covalently cross-linked polymer networks, demonstrate network polymers displaying both malleability and reprocessability. The networks is studied monitoring stress relaxation at varying temperature, their topology freezing temperatures...
One-way street: A new family of λ5-phospha[7]helicenes which form one-dimensional columnar stacks in the solid state were synthesized (see scheme). Neighboring have opposite dipole directions and, case racemic phosphole sulfide based helicene, columns with a given direction consist one enantiomer, whereas other enantiomer. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA total synthesis of aphidicolinBarry M. Trost, Yoshio Nishimura, and Kagetoshi YamamotoCite this: J. Am. Chem. Soc. 1979, 101, 5, 1328–1330Publication Date (Print):February 1, 1979Publication History Published online1 May 2002Published inissue 1 February 1979https://pubs.acs.org/doi/10.1021/ja00499a071https://doi.org/10.1021/ja00499a071research-articleACS PublicationsRequest reuse permissionsArticle Views2000Altmetric-Citations105LEARN ABOUT THESE...
Transparent X-ray shielding polymer films were developed by bulk photo copolymerization of in situ prepared bismuth carboxylate prepolymers with polymerizable exomethylene moieties and N,N-dimethylacrylamide (DMAA). The bismuth-containing via the polycondensation BiPh3, 2-octenylsuccinic acid (OSA), itaconic (IA) bearing an group for polymerization. OSA was a chain extender intermolecular condensation stopper intramolecular cyclization to inhibit cross-linkage. resulting photocured exhibit...
Programmed death 1 ligand (PD-L1), an important immune checkpoint molecule, is mainly expressed on cancer cells and has been shown to exert immunosuppressive effect T-cell function by binding programmed cell (PD-1) T-cells. Recently, inhibitors using antibody drugs such as nivolumab atezolizumab have attracted attention. However, clinical challenges, including limitations the scope of their application, are yet be addressed. In this study, we developed a novel inhibitor that targets PD-L1...
Frequency characteristics of a nonlinear lasing gain under the condition that laser oscillation exists at fixed frequency are theoretically obtained on basis band-to-level transition model (without <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</tex> - selection rule) semiconductor lasers. This exhibits spectral hole-burning in vicinity as well decrease from corresponding linear over entire region. The analysis uses semiclassical...
L-Iduronic acid-type 1-N-iminosugars, (3R,4S,5R,6R)- and (3R,4S,5S,6R)-6-acetamido-4-amino-5-hydroxypiperidine-3-carboxylic acid (6 7, respectively), (3R,4S,5R,6R)-6-acetamido-4- guanidino-5-hydroxypiperidine-3-carboxylic (8), (3R,4S,5R,6R)-4-amino- -guanidino-5-hydroxy-6-(trifluoroacetamido) piperidine-3-carboxylic (9 10, were synthesized from siastatin B (1), isolated Streptomyces culture, by the intramolecular Michael addition of O-imidate to its alpha,beta-unsaturated ester through cis...
Glucuronidation of morphine in humans is predominantly catalyzed by UDP-glucuronosyltransferase 2B7 (UGT2B7). Since our recent research suggested that cytochrome P450s (P450s) interact with UGT2B7 to affect its function [Takeda S et al. (2005) <i>Mol Pharmacol</i> 67:665–672], P450 inhibitors are expected modulate UGT2B7-catalyzed activity. To address this issue, we investigated the effects (cimetidine, sulfaphenazole, erythromycin, nifedipine, and ketoconazole) on formation...
Tripropeptin C (TPPC) is a naturally occurring cyclic lipodepsipeptide antibiotic produced by Lysobacter sp. TPPC exhibits potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and penicillin-resistant Streptococcus pneumoniae. This also inhibits the incorporation of N-acetylglucosamine into peptidoglycan S. at 50% inhibitory concentration (IC(50)) 0.7 μM, which proportional to its MIC (0.87 μM; equivalent 1.0...
Abstract The abuse of antibacterial drugs imposes a selection pressure on bacteria that has driven the evolution multidrug resistance in many pathogens. Our efforts to discover novel classes antibiotics combat these pathogens resulted discovery amycolamicin (AMM). absolute structure AMM was determined by NMR spectroscopy, X‐ray analysis, chemical degradation, and modification its functional groups. consists trans ‐decalin, tetramic acid, two unusual sugars (amycolose amykitanose),...
Functional protein-protein interactions between UDP-glucuronosyltransferase (UGT)1A isoforms and cytochrome P450 (CYP)3A4 were studied. To this end, UGT1A-catalyzed glucuronidation was assayed in Sf-9 cells that simultaneously expressed UGT CYP3A4. In the kinetics of UGT1A6-catalyzed serotonin, both Michaelis constant (<i>K</i><sub>m</sub>) maximal velocity (<i>V</i><sub>max</sub>) increased by When CYP3A4 coexpressed with either UGT1A1 or 1A7, <i>V</i><sub>max</sub> for irinotecan...
2,3,7,8-Tetrachlorodibenzo-<i>p</i>-dioxin (TCDD) and related substances are a class of environmental pollutants with suspected toxic effects on reproductive developmental processes. This study investigated hypothesis that maternal exposure to TCDD damages gonadotropin-regulated steroidogenesis in fetal gonads imprint defects sexual behavior as well the maturation gonadal tissues. Oral administration 1 μg/kg pregnant Wistar rats at gestational day (GD) 15 attenuated expression luteinizing...
Abstract 4-O-(3,4-Di-O-benzyl-2,6-dicarbobenzoxyamino-2,6-dideoxy-α-d-glucopyranosyl)-N,N′-dicar-bobenzoxy-2-deoxystreptamine has been prepared from neamine and condensed with 3-acetamido-2,4,6-tri-O-benzyl-3-deoxy-α-d-glucopyranosyl chloride by a modified Koenigs-Knorr reaction to give an α,α-diglycoside. The identity of the product substance same structure derived natural kanamycin B was shown. Removal masking groups gave synthetic B, which identical B.
We have demonstrated that an extract from the ripe fruit of Vitex agnus-castus (Vitex) exhibits cytotoxic activities against various types solid tumor cells, whereas its effects on leukemia cells has not been evaluated to date. In this study, and major component, casticin, cell lines, HL-60 U-937, were investigated by focusing proliferation, induction apoptosis differentiation. Identification quantitation NMR spectroscopy showed casticin accounted for approximate 1% weight Vitex....
An efficient and flexible synthetic route to four gem-diamine 1-N-iminosugars of uronic acid-type (D-glucuronic, D-mannuronic, L-iduronic, L-guluronic acid), a new family glycosidase inhibitor, from l-galactono-1,4-lactone have been developed in an enantiodivergent fashion through sequence involving as the key steps (a) formation 1-N-iminopyranose ring by Mitsunobu reaction aminal (b) introduction carboxylic acid group Wittig ketone, hydroboration oxidation, Sharpless oxidation. D-Glucuronic...