A5022099246- Peroxisome Proliferator-Activated Receptors
- Toxic Organic Pollutants Impact
- Birth, Development, and Health
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Effects and risks of endocrine disrupting chemicals
- Drug Transport and Resistance Mechanisms
- Biochemical Acid Research Studies
- Adipose Tissue and Metabolism
- Dermatology and Skin Diseases
- Metabolism, Diabetes, and Cancer
- Food Allergy and Anaphylaxis Research
- Eicosanoids and Hypertension Pharmacology
- Per- and polyfluoroalkyl substances research
- Electrolyte and hormonal disorders
- Selenium in Biological Systems
- Environmental Toxicology and Ecotoxicology
- Aortic aneurysm repair treatments
- Metabolomics and Mass Spectrometry Studies
- Innovation and Knowledge Management
- Contact Dermatitis and Allergies
- Natural product bioactivities and synthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Neurogenesis and neuroplasticity mechanisms
- Moyamoya disease diagnosis and treatment
Daiichi University of Pharmacy
2016-2025
Fukuoka University
2024
Pennsylvania State University
2013-2021
Kyushu University
2009-2017
Osaka University of Commerce
2002
Selenium-binding protein 1 (SeBP1) is an anticancer factor that affects lipid metabolism in mouse kidneys via the peroxisome proliferator-activated receptor-alpha (PPARA) pathway. However, its physiological role liver difficult to explain because of presence highly homologous selenium-binding 2 (SeBP2). To investigate these proteins liver, we generated SeBP1 and SeBP2 double-knockout mice (SeBP1/2-DK). SeBP1/2 deletion did not significantly alter phenotypic compared wild-type strain. Then,...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an endocrine disruptor, causes reproductive and developmental toxic effects in pups following maternal exposure a number of animal models. Our previous studies have demonstrated that TCDD imprints sexual immaturity by suppressing the expression fetal pituitary gonadotropins, regulators gonadal steroidogenesis. In present study, we discovered all TCDD-produced damage to production gonadotropins as well testicular steroidogenesis can be repaired...
2,3,7,8-Tetrachlorodibenzo-<i>p</i>-dioxin (TCDD) and related substances are a class of environmental pollutants with suspected toxic effects on reproductive developmental processes. This study investigated hypothesis that maternal exposure to TCDD damages gonadotropin-regulated steroidogenesis in fetal gonads imprint defects sexual behavior as well the maturation gonadal tissues. Oral administration 1 μg/kg pregnant Wistar rats at gestational day (GD) 15 attenuated expression luteinizing...
Dioxin and related chemicals alter the expression of a number genes by activating aryl hydrocarbon receptors (AHR) to produce variety disorders including hepatotoxicity. However, it remains largely unknown how these changes in gene are linked toxicity. To address this issue, we initially examined effect 2,3,7,8-tetrachrolodibenzo-p-dioxin (TCDD), most toxic dioxin, on hepatic serum metabolome male pubertal rats found that TCDD causes many level fatty acids, bile amino their metabolites....
Evidence suggests that species differences exist between rodents and humans in their biological responses to ligand activation of PPARα. Moreover, neonatal/postnatal may be more sensitive the effects activating Thus, present studies examined chronic PPARα initiated during early neonatal development continued into adulthood on hepatocarcinogenesis mice. Wild-type, Ppara-null, or PPARA-humanized mice were administered a potent, high-affinity human agonist GW7647, cohorts over time. Activation...
A growing body of experimental evidence strongly suggests that cannabidiolic acid (CBDA), a major component the fiber-type cannabis plant, exerts variety biological activities. We have reported CBDA can abrogate cyclooxygenase-2 (COX-2) expression and its enzymatic activity. It is established aberrant COX-2 correlates with degree malignancy in breast cancer. Although reduction by offers an attractive medicinal application, molecular mechanisms underlying these effects not fully been...
Detailed in vitro studies on the effects of perfluorooctanoic acid (PFOA) have demonstrated that activation peroxisome proliferator-activated receptor α (PPARα) is a key process by which PFOA affects malignancy estrogen (ERα)-positive breast cancer cells. However, there very little information PPARα-regulated genes responsible for ERα-negative cell malignancy. We recently fatty 2-hydroxylase (FA2H) stimulates migration human MDA-MB-231 cells, and PPARα factor induction FA2H these evidence...
The activation of aryl hydrocarbon receptor with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to be antagonized by co-treatment resveratrol. However, such a protective effect has been suggested from studies using subcutaneous injection this polyphenol. To evaluate the practical usefulness resveratrol, study examined oral resveratrol on sub-acute toxic effects TCDD in C57BL/6J mice. A TCDD-induced wasting syndrome was not alleviated treating mice for 28 d 5 significantly improved...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) reduces the synthesis of pituitary gonadotropins in a fetal age-specific manner. The is regulated by hypothalamus and, thus, needs differentiation and development requiring number factors including energy supply neurotransmitters. To investigate mechanism whereby TCDD gonadotropins, we carried out comparative study on metabolomes using mature Wistar rats. Male fetuses at gestational day (GD)20 were removed from dams treated orally with (1 microg/kg)...
Ppara-null and PPARA-humanized mice are refractory to hepatocarcinogenesis caused by the peroxisome proliferator-activated receptor-α (PPARα) agonist Wy-14,643. However, duration of these earlier studies was limited approximately 1 year treatment, ligand used has a higher affinity for mouse PPARα compared human PPARα. Thus, present study examined effect long-term administration potent, high-affinity (GW7647) on in wild-type, Ppara-null, or mice. In wild-type mice, GW7647 hepatic expression...
Selenium-binding protein 1 (Selenbp1) is a 2,3,7,8-tetrechlorodibenzo-p-dioxin inducible whose function yet to be comprehensively elucidated. As the highly homologous isoform, Selenbp2, expressed at low levels in kidney, it worthwhile comparing wild-type C57BL mice and Selenbp1-deficient under dioxin-free conditions. Accordingly, we conducted mouse metabolomics analysis non-dioxin-treated DNA microarray was performed based on observed changes lipid metabolism-related factors. The results...
Our previous studies demonstrated that treating pregnant rats with dioxins, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), targets the pituitary expression of luteinizing hormone (LH) to attenuate testicular steroidogenesis in fetuses, resulting imprinting sexual immaturity offspring after reaching maturity. Furthermore, we found although TCDD disturbs tricarboxylic acid (TCA) cycle fetal hypothalamus, maternal co-treatment α-lipoic (α-LA), a cofactor TCA cycle, restores TCDD-produced...
MF59, which is an adjuvant belonging to C₃₀ member of the terpene family, a T helper type-2 (Th2)-biased immune enhancer. Our previous studies showed that pyriproxyfen, family with fewer carbon atoms (C₂₀) than enhanced active type-1 (Th1)-biased responses.This study was performed investigate enhancement antigen-specific responses by myrcene, (C₁₀) pyriproxyfen.Ovalbumin (OVA) used as antigen determine effects myrcene on response. The IgG subtypes and cytokines induced immunization OVA or...
In STA-MCA bypass surgery, it is important to select the optimal recipient using preoperative simulation avoid complications. We report a for Brain LAB iPLAN platform
Efficacy of tumor embolization for posterior fossa meningioma is controversial due to the lack adequate dangerous feeders. Of these, a meningohypophyseal trunk (MHT) has high therapeutic value despite risks associated with embolization.
Hachimijiogan (HJG) has originally been used to ameliorate a variety of symptoms associated with low ambient temperatures. However, its pharmacological action in metabolic organs remains unclear. We hypothesized that HJG may modulate function and have potential therapeutic application diseases. To test this hypothesis, we investigated mice. Male C57BL/6J mice chronically administered showed reduction adipocyte size increased transcription beige adipocyte-related genes subcutaneous white...
Atopic dermatitis (AD) is a skin disorder that presents with itching and scratching frequently progresses to chronic state. AD often develops in patients an individual or family history of allergic diseases. In addition, may develop exposed environmental stimuli such as air pollutants dust. However, there can be differences the magnitude symptoms between even same genetic background exposure similar conditions. NC/Nga mice have been used model for AD. They show AD-like age-dependent manner,...