A5015426068- Cardiac Imaging and Diagnostics
- Blood Coagulation and Thrombosis Mechanisms
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Ovarian cancer diagnosis and treatment
- Complement system in diseases
- Cancer-related Molecular Pathways
- Coronary Artery Anomalies
- Platelet Disorders and Treatments
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- RNA Interference and Gene Delivery
- Voice and Speech Disorders
- Cell death mechanisms and regulation
- Dysphagia Assessment and Management
- Virus-based gene therapy research
- Vitamin D Research Studies
- Venous Thromboembolism Diagnosis and Management
- Cancer Research and Treatments
- Cardiac Fibrosis and Remodeling
- Barrier Structure and Function Studies
Nagoya Kyouritsu Hospital
2018-2023
Fukushima Medical University
1996-2023
Japanese Red Cross Kumamoto Hospital
2020-2021
Tokushima University Hospital
2019
Institute of Biomedical Science
2017-2018
Tokushima University
2016-2018
Saiseikai Kumamoto Hospital
2009-2017
National Hospital Organization
2017
Iwaki Kyoritsu General Hospital
2017
Saiseikai Utsunomiya hospital
2016-2017
To test whether angiotensin II receptor blockers (ARBs) therapy can reduce the incidence of cardiovascular events compared with non-ARB-based standard pharmacotherapy in coronary artery disease (CAD) patients hypertension. Angiographically documented CAD hypertension were randomly assigned to receive either candesartan-based (n= 1024) or including angiotensin-converting enzyme-inhibitors (n = 1025). The primary endpoint was occurrence a first major adverse event (MACE). There 552 during...
Wilms tumor gene (WT-1) expression has been reported in many human cancers, including most ovarian and peritoneal serous carcinomas, but not studied carcinomas of the fallopian tube. In this study, authors evaluated immunohistochemical WT-1 tube compared their reactivity with that ovarian, peritoneal, endometrial carcinomas. All primary (13 cases), ovaries (25 peritoneum (3 cases) were reactive antibody, whereas all five nonreactive. an unknown carcinoma is therefore suggestive extrauterine...
Class A macrophage scavenger receptor (SR-A) is a macrophage-restricted multifunctional molecule that optimizes the inflammatory response by modulation of activity cytokines. This study was conducted with SR-A-deficient (SR-A(-/-)) mice to evaluate relationship between SR-A and cardiac remodeling after myocardial infarction.Experimental infarction (MI) produced ligation left coronary artery in SR-A(-/-) wild-type (WT) male mice. The number died within 4 weeks MI significantly greater than WT...
Among the claudin (CLDN) family, CLDN6 exhibits aberrant expression in various cancers, but its biological relevance has not yet been established. We generated a monoclonal antibody (mAb) against human and verified specificity. By immunohistochemical staining semi-quantification, we evaluated relationship between clinicopathological parameters tissues from 173 cases of endometrial cancer.The established mAb selectively recognized protein. Ten (5.8%) showed high (score 3+), whereas 19...
Desmoplastic small round cell tumors are extremely rare, occurring primarily in young males. This disease is characterized by the reciprocal translocation of EWS-WT1 fusion gene. Treatment for this tumor multidisciplinary, including surgery, chemotherapy, and radiation therapy. The progresses rapidly even with complete resection, local recurrence, distant metastasis likely to occur prognosis poor. report describes a case primary ovarian cancer 33-year-old woman. pre-operative test showed...
Abstract Mutations in the p53 gene are associated with a wide variety of human malignancies. Point mutation one allele and loss remaining generally lead to inactivation protein. A high frequency allelic losses corresponding 17p13.3 region that contained sequence was also noted endometrial carcinoma. Thus, order confirm involvement carcinogenesis, we searched for nucleotide change this 42 carcinomas had been subjected previous LOH analyses. Using polymerase‐chain‐reaction‐single‐strand...
The purpose of this study was to characterize the swallowing sound and identify process generation during in young healthy adults.Thirty-three volunteers were enrolled allocated into three experimental groups. In experiment 1, a microphone attached one eight cervical sites 20 subjects, participants swallowed 5 ml water, waveform recorded. 2, 10 subjects either 0, 5, 10, or 15 water audio recording. addition, consumed bolus two different postures. 3, videofluoroscopy simultaneously recorded...
Abstract The present study was undertaken to define the gene(s) of importance on long arm chromosome 18 (chromosome 18q) in endometrial carcinomas. We analyzed loss heterozygosity (LOH) at 3 loci 18q and DCC gene expression by reverse‐transcriptase/polymerase chain reaction (RT‐PCR) method. Among 61 tumors that were informative, 16 (26%), estimated be a minimum number, showed allelic losses one or more loci. Deletions these possibly involved region within near 21.3 band where localized....
Background: Early detection and treatment to sarcopenia presbyphagia are needed address the problems experienced by an aging population. Objective: We aimed clarify morphological changes in geniohyoid (GH) muscle associated aging-related factors, examine if GH predict reduced swallowing function. Materials Methods: 103 participants (57 women 46 men, mean age 59.4 ± 19.5 years) were recruited. cross-sectional area (CSA) contraction velocity measured using ultrasonography. Body height weight,...
Using a binary co-transfection strategy of Ad/GT Bax and Ad/PGK-GV16, we have succeeded in inducing overexpression protein three prostate cell lines (androgen-insensitive DU145 PC3, androgen-sensitive LNCaP). The expression by this system was sufficient to induce all undergo apoptosis. fact that cells which p53 mutation are deficient Bax, responded treatment, suggests effect is independent these pathways. Initiation the cleavage Caspase-3 (CPP32/Yama/apopain) PARP (poly (ADP-ribose)...
Adenoviral vectors expressing wild-type p53 (Ad-p53) induce apoptosis in different types of cancer cells. The therapeutic utility Ad-p53 is now being evaluated prostate-cancer patients. Bcl-2 frequently expressed by cells and has previously been shown to inhibit p53-mediated cell death following genotoxic stress. We studied the impact bcl-2 on Ad-p53-induced human Human lines LNCaP (p53 wt) PC3 mut) were stably transfected with bcl-2. After transduction, viability, induction modulation...
Institutional review board approval was obtained for multiple imaging examinations in healthy volunteers and patients the analysis of images. The purpose study, risks associated with radiation exposure regard to stochastic effects that might result cancer and/or genetic mutations, were explained all subjects, questions from subjects answered. Each subject provided written informed consent. study prospectively determine respiratory protocol at computed tomography (CT) results best...
The purpose of this study was to develop a method fused images coronary CT angiography and myocardial perfusion SPECT.Four patients with ischemic heart disease underwent 3D volume-rendering using conversion program fusion function computer workstation. clearly showed the relationship relevant arteries abnormal territory in all were useful for evaluation artery disease.