A5083203382- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Fibroblast Growth Factor Research
- Genetic factors in colorectal cancer
- Gynecological conditions and treatments
- Maternal and fetal healthcare
- RNA Research and Splicing
- Gestational Trophoblastic Disease Studies
- DNA Repair Mechanisms
- Prostate Cancer Treatment and Research
- Cervical Cancer and HPV Research
- Cancer Risks and Factors
- Economic and Financial Impacts of Cancer
- Vasculitis and related conditions
- Ectopic Pregnancy Diagnosis and Management
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Reproductive Biology and Fertility
- Maternal and Perinatal Health Interventions
- Intraperitoneal and Appendiceal Malignancies
- Endometriosis Research and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Radiomics and Machine Learning in Medical Imaging
Juntendo University
2018-2024
Tokyo National Hospital
2023
National Cancer Center Hospital East
2023
Kyoto University
2023
National Cancer Research Institute
2022
National Cancer Centre Japan
2022
Juntendo University Hospital
2017
Abstract The clinical features of sporadic mismatch repair deficiency (MMRd) and Lynch syndrome (LS) in Japanese patients with endometrial cancer (EC) were examined by evaluating the prevalence prognostic factors LS MMRd EC. Targeted sequencing five susceptibility genes ( MLH1 , MSH2 MSH6 PMS2 EPCAM ) was carried out 443 EC who pathologically diagnosed at National Cancer Center Hospital between 2011 2018. Pathogenic variants these detected 16 (3.7%). Immunohistochemistry for MMR proteins...
The prognosis of gynecological malignancies has improved with the recent advent molecularly targeted drugs and immune checkpoint inhibitors. However, these are expensive contribute to increasing costs medical care.
To review and evaluate drug-induced vasculitis, which is an extremely rare complication of chemotherapy. A 47-year-old woman with ovarian cancer developed aortitis during bevacizumab combination Contract-enhanced CT showed concentric thickening the descending aorta. Antibiotics were administered, but a repeat CE-CT scan no resolution aortitis. treat aortitis, she was started on oral prednisolone. subsequent signs She thus re-started modified chemotherapy regimen. Aortitis should be...
Abstract Germline pathogenic variants (PVs) are pivotal in gynecological oncology. We focused on the prevalence, clinicopathological features, and survival impact of homologous recombination repair (HRR) PVs patients with epithelial ovarian cancer (EOC). This was a multicenter retrospective cohort study, 1248 EOC were registered. Eligible ( n = 1112) underwent germline DNA analysis for 26 predisposition genes, including nine HRR‐related such as BRCA1/2 , BRIP1 PALB2 RAD51C/D ATM . The...
Although cervical cancer is often characterized as preventable, its incidence continues to increase in low- and middle-income countries, underscoring the need develop novel therapeutics for this disease.This study assessed distribution of fusion genes across types used an RNA-based classification divide patients with a poor prognosis into subgroups.RNA sequencing 116 was conducted. Fusion were extracted using StarFusion program. To identify high-risk group recurrence, 65 who received...
Cervical adenocarcinoma (ADC) is the second most common pathological subtype of cervical cancer after squamous cell carcinoma. It accounts for approximately 20% cancers, and incidence has increased in past few decades, particularly among young patients. The persistent infection high-risk human papillomavirus (HPV) responsible ADC. However, almost all available vitro models are designed to study carcinogenesis To gain better insights into molecular background ADC, we aimed establish an model...
Postpartum haemorrhage is one of the leading causes maternal morbidity and mortality (Maswime Buchmann 2017). Several haemostatic surgical techniques during caesarean section have been repor...
Objective: Fertility preservation therapy using high-dose medroxyprogesterone acetate (MPA) is effective for young patients with atypical endometrial hyperplasia (AEH) and early cancer (EC).However, its high recurrence rate has been concerned.Methods: This study included 173 who achieved complete remission (CR) relapsed after initial MPA at our hospital from 1998 2021.We analyzed the efficacy of repeated recurrent AEH EC.Results: The median observation period was 172.5 months.The...
Peutz-Jeghers syndrome (PJS) is associated with female genital lesions, such as cervical gastric-type adenocarcinoma and lobular endocervical glandular hyperplasia (LEGH). However, ovarian mucinous borderline tumors (OMBT) atypical LEGH-like histology have not been described. The patient was a 60-year-old PJS clinically diagnosed at 23 years old gastrointestinal polyposis. Abdominal distension noted, computed tomography scan revealed bilateral breast masses, multiple lung nodules,...
Objective: Initial treatment decision between primary debulking surgery (PDS) and neoadjuvant chemotherapy (NAC) followed by interval (IDS) for patients diagnosed with advanced ovarian cancer is still challenging.The purpose of our study was to establish a machine learning based prediction model optimize the initial selection using clinical variables combined features extracted from positron emission tomography/computed tomography (PET/CT).Methods: Between 2009 2021, 109 who underwent PET/CT...
Congenital cervical atresia is an extremely rare condition that often accompanied with vaginal agenesis and uterine malformations; therefore, its management remains controversial. Here, we present the case of a 17-year-old female primary amenorrhea. After examination investigation, she was diagnosed isolated congenital atresia. We conducted laparoscopic assisted reconstruction. harvesting portion peritoneum in pelvis, laparoscopically incised anterior wall uterus to confirm cavity definitely...
Abstract Lymph node metastasis (LNM) is a well-established prognostic factor in endometrial cancer (EC). We aimed to construct model that predicts LNM and prognosis using preoperative factors such as myometrial invasion (MI), enlarged lymph nodes (LNs), histological grade determined by biopsy, serum antigen 125 (CA125) level two independent cohorts consisting of 254 EC patients. The area under the receiver operating characteristic curve (AUC) constructed was 0.80 regardless machine learning...
Objective: The aim of this research was to review and assess early stage uterine adenosarcoma. Materials Methods: A retrospective performed using the records 9 patients with Results: median patient age 60 (range: ages 41–81). Seven presented vaginal bleeding as their primary symptom, other 2 low abdominal pain. After becoming pregnant, 1 previously nulliparous who underwent fertility-preservation surgery had a delivery before undergoing total hysterectomy. All eventually hysterectomy...