A5022231939- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Pediatric Pain Management Techniques
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
University of Alabama at Birmingham
2023
Abstract Background Mammalian mucosal barriers secrete antimicrobial peptides (AMPs) as critical, host-derived regulators of the microbiota. However, mechanisms that support microbiota homeostasis in response to inflammatory stimuli, such supraphysiologic oxygen, remain unclear. Results We show oxygen exposure neonatal mice, or direct intestinal organoids suppresses expression AMPs and alters composition. Oral supplementation prototypical AMP lysozyme hyperoxia-exposed mice reduced...
Mammalian mucosal barriers secrete antimicrobial peptides (AMPs) as critical host-derived regulators of the microbiota. However, mechanisms that support homeostasis microbiota in response to inflammatory stimuli such supraphysiologic oxygen remain unclear. Here, we show neonatal mice breathing or direct exposure intestinal organoids suppress expression AMPs and alters composition Oral supplementation prototypical AMP lysozyme hyperoxia exposed reduced hyperoxia-induced alterations their was...