A5070408026- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Systemic Lupus Erythematosus Research
- Drug-Induced Adverse Reactions
- Cytokine Signaling Pathways and Interactions
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Genomic variations and chromosomal abnormalities
- Hepatitis C virus research
- Inflammatory mediators and NSAID effects
- Alcohol Consumption and Health Effects
- IL-33, ST2, and ILC Pathways
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Metabolism, Diabetes, and Cancer
- Congenital gastrointestinal and neural anomalies
- Immune Response and Inflammation
- Mast cells and histamine
- Pluripotent Stem Cells Research
- Genetics and Neurodevelopmental Disorders
Sogang University
2016-2025
Institute for Basic Science
2014-2025
SNP Genetics (South Korea)
2013-2023
PharmacoGenetics (China)
2014
Center for Genomic Science
1998-2014
Hanyang University
2008-2011
Hangang Sacred Heart Hospital
2011
Hallym University
2011
Seoul National University
2006-2011
Soonchunhyang University Hospital
2005-2010
SummaryThe CCR5-Δ32 deletion obliterates the CCR5 chemokine and human immunodeficiency virus (HIV)–1 coreceptor on lymphoid cells, leading to strong resistance against HIV-1 infection AIDS. A genotype survey of 4,166 individuals revealed a cline allele frequencies 0%–14% across Eurasia, whereas variant is absent among native African, American Indian, East Asian ethnic groups. Haplotype analysis 192 Caucasian chromosomes linkage disequilibrium between two microsatellite loci. By use...
Recent genome-wide association studies have identified six novel genes for type 2 diabetes and obesity confirmed TCF7L2 as the major gene to date in Europeans. However, implications of these Asians are unclear.We studied 13 associated single nucleotide polymorphisms from 3,041 patients with 3,678 control subjects Asian ancestry Hong Kong Korea.We associations TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/CDKN2B, IGF2BP2, FTO risk diabetes, odds ratios ranging 1.13 1.35 (1.3 x 10(-12) < P(unadjusted)...
Knowledge regarding the genetic risk loci for gestational diabetes mellitus (GDM) is still limited. In this study, we performed a two-stage genome-wide association analysis in Korean women. stage 1 genome scan, 468 women with GDM and 1,242 nondiabetic control were compared using 2.19 million genotyped or imputed markers. We selected 11 further genotyping 2 samples of 931 case 783 subjects. The joint effect plus studies was analyzed by meta-analysis. also investigated known type variants GDM....
IL10 is a powerful TH-2 cell cytokine produced by lymphoid cells that limits HIV-1 replication in vivo, ostensibly inhibiting macrophage/monocyte and T-cell lymphocyte secretion of inflammatory cytokines (IL1, TNFalpha, IL6, IL8, IL12). A genetic epidemiological scan patients enrolled AIDS cohorts for candidate gene-linked short tandem repeat polymorphisms revealed significant genotype associations infection progression to with markers adjacent tracking (by linkage disequilibrium) common...
<h3>Objective</h3> Crohn9s disease (CD) is an intractable inflammatory bowel (IBD) of unknown cause. Recent meta-analysis the genome-wide association studies (GWAS) and Immunochip data identified 163 susceptibility loci to IBD in Caucasians, however there are limited other populations. <h3>Methods</h3> We performed a GWAS two validation Korean population comprising total 2311 patients with CD 2442 controls. <h3>Results</h3> confirmed four previously reported loci: <i>TNFSF15</i>,...
Abstract Background Recently, the discovery of copy number variation (CNV) led researchers to think that there are more variations genomic DNA than initially believed. Moreover, a certain CNV region has been found be associated with onset diseases. Therefore, is now known as an important in biological mechanisms. However, most studies have only involved human genome. The study involving other animals, including cattle, severely lacking. Results In our we used Illumina BovineSNP50 BeadChip...
<h3>Objective</h3> A highly polygenic aetiology and high degree of allele-sharing between ancestries have been well elucidated in genetic studies rheumatoid arthritis. Recently, the high-density genotyping array Immunochip for immune disease loci identified 14 new arthritis risk among individuals European ancestry. Here, we aimed to identify using Korean-specific data. <h3>Methods</h3> We analysed Korean case–control samples genome-wide association (GWAS) search alleles with...
Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Recently, several genome-wide association studies (GWASs) of CHB identified human leukocyte antigen (HLA) loci, including HLA-DP HLA-DQ in Asian populations, as being associated with CHB. To confirm identify host genetic factors related to infection, we performed another GWAS using a higher-density chip Korean carriers. We analyzed 1400...
It has been newly reported in recent studies that single-nucleotide polymorphisms (SNPs) the first intron of FTO gene have associated with BMI whites. To determine whether is Asians also, we performed a replication study association Korean population. Two SNPs (rs1421085 and rs17817449) were genotyped using TaqMan method population (n = 1,733). The two then used for an through statistical analyses. rs1421085 C allele (P 0.0015, effect size 0.0056) rs17817449 G 0.0019, 0.0053) found to be...
It has been suggested that genetic susceptibility plays an important role in the pathogenesis of diabetic nephropathy. A large-scale genotyping analysis gene-based single nucleotide polymorphisms (SNPs) Japanese patients with type 2 diabetes identified gene encoding acetyl-coenzyme carboxylase beta (ACACB) as a candidate for to nephropathy; landmark SNP was found intron 18 ACACB (rs2268388: +4139 C > T, p = 1.4×10−6, odds ratio 1.61, 95% confidence interval [CI]: 1.33–1.96). The association...
Genomic changes frequently occur in cancer cells during tumorigenesis from normal cells. Using the Illumina Human NS-12 single-nucleotide polymorphism (SNP) chip to screen for gene copy number primary hepatocellular carcinomas (HCCs), we initially detected amplification of 35 genes four genomic regions (1q21-41, 6p21.2-24.1, 7p13 and 8q13-23). By integrated screening these both DNA expression HCC colorectal cancer, selected CENPF (centromere protein F/mitosin), GMNN (geminin, replication...
Recent genome-wide association studies and meta-analyses have identified 47 susceptibility loci for ulcerative colitis (UC) in Caucasian populations. A previous study of UC a Japanese population suggested marginal sharing between Asian We performed to identify Korean further comparative study.We analyzed 581,060 autosomal single-nucleotide polymorphisms (SNPs) 388 individuals with 739 control subjects the discovery stage. For validation, 64 suggestive SNPs were an additional 417 affected 732...
Crohn's disease (CD) is an intractable inflammatory bowel of unknown cause. Recent genome-wide association studies CD in Korean and Japanese populations suggested marginal sharing susceptibility loci between Caucasian Asian populations. As the 7 identified altogether explain 5.31% risk for CD, objective this study was to identify additional population.Using ImmunoChip custom single-nucleotide polymorphism array designed dense genotyping 186 through GWAS, we analyzed 722 individuals with 461...
Summary Background A disintegrin and metalloprotease 33 (ADAM33) is expressed in the lung by fibroblasts bronchial smooth muscle cells. Given its structure cellular provenance, ADAM33 may be associated with airway remodelling hyper‐responsiveness. Single nucleotide polymorphisms (SNPs) haplotypes of gene have previously been asthma susceptibility Caucasian population. Objective Methods To assess whether genetic variants are related to a Korean population, we conducted an association study...
Objectives and methods The cysteinyl leukotriene receptor 2 (CYSLTR2) gene on chromosome 13q14.12–q21.1 encodes a for CYSLTs, potent biological mediators in the pathogenesis of asthma, particularly that associated with aspirin intolerance (AIA). In an effort to discover additional polymorphism(s), variant(s) which have been implicated asthma intolerance, we scrutinized genetic polymorphisms CYSLTR2 gene, evaluated this locus as potential candidate asthma. Results DNA sequencing 24 Koreans...