A5018565617- 3D Printing in Biomedical Research
- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Tissue Engineering and Regenerative Medicine
- Monoclonal and Polyclonal Antibodies Research
- Radiation Therapy and Dosimetry
- Cardiac electrophysiology and arrhythmias
- Cellular Mechanics and Interactions
- Microfluidic and Bio-sensing Technologies
- Generative Adversarial Networks and Image Synthesis
- Spaceflight effects on biology
- Neuroscience and Neural Engineering
- Medical Image Segmentation Techniques
- Cardiovascular Function and Risk Factors
- Aesthetic Perception and Analysis
- Blood properties and coagulation
- AI in cancer detection
- ECG Monitoring and Analysis
- COVID-19 diagnosis using AI
- Face recognition and analysis
- Anesthesia and Neurotoxicity Research
- Pluripotent Stem Cells Research
- Analog and Mixed-Signal Circuit Design
- Molecular Communication and Nanonetworks
- Wireless Body Area Networks
Columbia University
2021-2024
Chung-Ang University
2024
University of California, Berkeley
2018-2019
Berkeley College
2018
Abstract Galactic cosmic radiation (GCR) is one of the most serious risks posed to astronauts during missions Moon and Mars. Experimental models capable recapitulating human physiology are critical understanding effects on organs developing radioprotective measures against space travel exposures. The systemic studied using a multi‐organ‐on‐a‐chip (multi‐OoC) platform containing engineered tissue bone marrow (site hematopoiesis acute damage), cardiac muscle chronic damage) liver metabolism),...
Resident cardiac macrophages are critical mediators of function. Despite their known importance to electrophysiology and tissue maintenance, there currently no stem-cell-derived models human engineered tissues (hECTs) that include resident macrophages. In this study, we made an induced pluripotent stem cell (iPSC)-derived hECT model with a population (iM0) better recapitulate the native myocardium characterized impact on Macrophage retention within hECTs was confirmed via immunofluorescence...
Engineered cardiac tissues derived from human induced pluripotent stem cells (iPSCs) are increasingly used for drug discovery, pharmacology and in models of development disease. While there numerous platforms to engineer tissues, they often require expensive nonconventional equipment utilize complex video-processing algorithms. As a result, only specialized academic laboratories have been able harness this technology. In addition, methodologies tissue features challenging reproduce between...
Systemic lupus erythematosus (SLE) is a heterogenous autoimmune disease that affects multiple organs, including the heart. The mechanisms of myocardial injury in SLE remain poorly understood. In this study, we engineered human cardiac tissues and cultured them with IgG from patients SLE, without involvement. elevated inflammation exhibited increased binding to apoptotic cells within subjected stress, whereas systolic dysfunction enhanced surface live cardiomyocytes. Functional assays RNA...
Cardiomyocytes derived from human induced pluripotent stem (iPS) cells enable the study of cardiac physiology and developmental testing new therapeutic drugs in a setting. In parallel, machine learning methods are being applied to biomedical science unprecedented ways. Machine has been used distinguish healthy diseased cardiomyocytes using calcium (Ca2+) transient signals. Most Ca2+ signals obtained via terminal assays that do not permit longitudinal studies, although some recently developed...
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Goal:</i> Contractile response and calcium handling are central to understanding cardiac function physiology, yet existing methods of analysis quantify these metrics often time-consuming, prone mistakes, or require specialized equipment/license. We developed BeatProfiler, a suite tools designed contractile function, handling, force generation for multiple in vitro models apply downstream machine...
Systemic lupus erythematosus (SLE) is a highly heterogenous autoimmune disease that affects multiple organs, including the heart. The mechanisms by which myocardial injury develops in SLE, however, remain poorly understood. Here we engineered human cardiac tissues and cultured them with IgG fractions containing autoantibodies from SLE patients without involvement. We observed unique binding patterns of two patient subgroups: (i) severe inflammation exhibited enhanced to apoptotic cells...
A considerable number of patients with systemic lupus erythematosus (SLE) develop myocardial injury. SLE have highly heterogenous populations autoantibodies that may contribute to cardiac disease pathogenesis and heterogeneity; however, little is known about their direct role in Here, we engineered a model matured human tissue used it study induced To this end, cultured tissues immunoglobulin G (IgG) from without We found IgG binding levels differed between patient groups correlated measures...
The media art production “Chemistry” uses deep learning network models to animate the rejuvenation of an aged face against backdrop four seasonal changes and life cycle flowers over time. team used Adobe Premiere After Effects illustrate seasons flowers. authors generated images rejuvenated faces with generative adversarial networks, AI technology. To create harmony between background, flowers, face, applied a style transfer adjust for person that background flower illustration. This work...