A5032145443- Single-cell and spatial transcriptomics
- Sirtuins and Resveratrol in Medicine
- Cardiovascular Function and Risk Factors
- Advanced Biosensing Techniques and Applications
- Drug Solubulity and Delivery Systems
- Ginseng Biological Effects and Applications
- Cell Image Analysis Techniques
- Cardiac electrophysiology and arrhythmias
- Protein Interaction Studies and Fluorescence Analysis
- Pharmacological Effects of Natural Compounds
- GABA and Rice Research
- Cancer Genomics and Diagnostics
- Chromatography in Natural Products
- Advanced Fluorescence Microscopy Techniques
- ECG Monitoring and Analysis
- Polysaccharides Composition and Applications
Columbia University
2024
Oregon Health & Science University
2024
Northeast Forestry University
2014-2015
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Goal:</i> Contractile response and calcium handling are central to understanding cardiac function physiology, yet existing methods of analysis quantify these metrics often time-consuming, prone mistakes, or require specialized equipment/license. We developed BeatProfiler, a suite tools designed contractile function, handling, force generation for multiple in vitro models apply downstream machine...
ABSTRACT Multiplexed tissue imaging (MTI) and other spatial profiling technologies commonly utilize serial sectioning to comprehensively profile samples by each section with unique biomarker panels or assays. The dependence on sections is attributed technological limitations of MTI panel size incompatible multi-assay protocols. Although image registration can align serially sectioned MTIs, integration at the single-cell level poses a challenge due inherent biological heterogeneity. Existing...
To improve the water solubility and dissolution rate, genipin was nanocrystallized by an emulsion solvent evaporation method, followed freeze‐drying. The optimization condition of nanocrystallization process carried out single‐factor experiment. effects five experimental parameters, such as concentration surfactants proportion to organic phase, homogenate speed time, homogenization pressure times, lyoprotectants on mean particle size (MPS) nanoparticles, were investigated. Under optimum...
Total Panax notoginsenosides nanoparticles, typical multicomponent extracts from traditional Chinese medicine, were prepared with a supercritical antisolvent (SAS) process using ethanol as solvent and carbon dioxide antisolvent. The optimum conditions determined to be follows: TPNS solution concentration of 2.5 mg/mL, flow rate 6.6 mL/min, precipitation temperature 40°C, pressure 20 MPa. Under the conditions, nanoparticles MPS 141.5 ± 18.2 nm total saponins amounts (TSA) 78.9% obtained....
Multiplexed tissue imaging (MTI) technologies enable high-dimensional spatial analysis of tumor microenvironments but face challenges with technical variability in staining intensities. Existing normalization methods, including z-score, ComBat, and MxNorm, often fail to account for the heterogeneous, right-skewed expression patterns MTI data, compromising signal alignment downstream analyses. We present UniFORM, a non-parametric, Python-based pipeline normalizing both feature- pixel-level...