A5021743120- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- Phagocytosis and Immune Regulation
- Antifungal resistance and susceptibility
- Ubiquitin and proteasome pathways
- Immunodeficiency and Autoimmune Disorders
- interferon and immune responses
- Immune cells in cancer
- Allergic Rhinitis and Sensitization
- Cystic Fibrosis Research Advances
- Immune responses and vaccinations
Charité - Universitätsmedizin Berlin
2016-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2023
Humboldt-Universität zu Berlin
2018-2021
Freie Universität Berlin
2019-2021
Severe COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathology, it remains unclear whether T cells contribute disease pathology. Here, we combined single-cell transcriptomics proteomics with mechanistic studies assess pathogenic cell functions inducing signals. We identified highly activated CD16
Abstract All memory T cells mount an accelerated response on antigen reencounter, but significant functional heterogeneity is present within the respective T-cell subsets as defined by CCR7 and CD45RA expression, thereby warranting further stratification. Here we show that several surface markers, including KLRB1, KLRG1, GPR56, KLRF1, help define low, high, or exhausted cytokine producers human peripheral intrahepatic CD4 + populations. Highest simultaneous production of TNF IFN-γ observed...
BACKGROUNDThe fungus Aspergillus fumigatus causes a variety of clinical phenotypes in patients with cystic fibrosis (pwCF). Th cells orchestrate immune responses against fungi, but the types A. fumigatus-specific pwCF and their contribution to protective immunity or inflammation remain poorly characterized.METHODSWe used antigen-reactive T cell enrichment (ARTE) investigate fungus-reactive peripheral blood healthy controls.RESULTSWe show that clonally expanded, high-avidity effector cells,...
Significance T helper type (Th) 9 cells demonstrate both pro- and antiinflammatory properties, pointing to a functional heterogeneity not examined so far. Applying single cell gene expression analysis of alloreactive Th9 cells, we revealed the existence two major subsets, CD96 high low with strongly opposing inflammatory and, especially, colitis-inducing potential. Mechanistically, found that controls cytokine potential providing strong evidence for an inhibitory role in controlling CD4 +...
Abstract Advanced age is the most important risk factor for severe disease or death from COVID-19, but a thorough mechanistic understanding of molecular and cellular underpinnings lacking. Multi-omics analysis samples SARS-CoV-2 infected persons aged 1 to 84 years, revealed rewiring type I interferon (IFN) signaling with gradual shift signal transducer activator transcription (STAT1) STAT3 activation in monocytes, CD4 + T cells B increasing age. Diversion IFN was associated increased...
Abstract T cells need to adapt their cellular metabolism for effector cell differentiation. This relies on alterations in mitochondrial physiology. Which signals and molecules regulate those remains unclear. We recently reported, that the protein TCAIM inhibits activation-induced changes morphology function thus, CD4 + formation. Using conditional knock-in (KI) knockout (KO) mice, we now show it also applies CD8 more importantly, delineate molecular processes mitochondria by which controls...