A5016218153- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Polyomavirus and related diseases
- vaccines and immunoinformatics approaches
- Renal Transplantation Outcomes and Treatments
- COVID-19 Impact on Reproduction
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immune responses and vaccinations
- Bone health and osteoporosis research
- Inflammasome and immune disorders
- Hepatitis B Virus Studies
- Vaccine Coverage and Hesitancy
- Antifungal resistance and susceptibility
- Atherosclerosis and Cardiovascular Diseases
- Full-Duplex Wireless Communications
- Single-cell and spatial transcriptomics
- Infectious Encephalopathies and Encephalitis
- Immune Response and Inflammation
- Influenza Virus Research Studies
Charité - Universitätsmedizin Berlin
2015-2025
Humboldt-Universität zu Berlin
2018-2025
Freie Universität Berlin
2018-2025
Universitätsklinik Marien Hospital Herne
2015-2024
Ruhr University Bochum
2015-2024
University Hospitals of the Ruhr-University of Bochum
2018-2024
LWL-Universitätsklinikum Bochum
2018-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2018-2023
Immundiagnostik (Germany)
2021-2022
German Rheumatism Research Centre
2009-2022
Abstract Here, we report an update of the VDJdb database with a substantial increase in number T-cell receptor (TCR) sequences and their cognate antigens. The further provides new infrastructure featuring two additional analysis modes that facilitate querying real-world data analysis. increased yield TCR specificity identification methods overall studies field has allowed us to expand more than 5-fold. Furthermore, several are included. For example, batch annotation repertoire sequencing...
Dialysis and kidney transplant patients are vulnerable populations for COVID-19 related disease mortality.
B lymphocytes can suppress immunity through interleukin (IL)-10 production in infectious, autoimmune, and malignant diseases. Here, we have identified a natural plasma cell subset that distinctively expresses the inhibitory receptor LAG-3 mediates this function vivo. These cells also express receptors CD200, PD-L1, PD-L2. They develop from various subsets (BCR)-dependent manner independently of microbiota naive mice. After challenge they upregulate IL-10 expression via Toll-like...
Abstract At present, it is not clear how memory B lymphocytes are maintained over time, and whether only as circulating cells or also residing in particular tissues. Here we describe distinct populations of isotype-switched (Bsm) murine spleen bone marrow, identified according to individual transcriptional signature cell receptor repertoire. A population marginal zone-like located exclusively the spleen, while a quiescent Bsm found marrow. Three further resident populations, present...
T cell immunity toward SARS-CoV-2 spike (S-), membrane (M-), and nucleocapsid (N-) proteins may define COVID-19 severity. Therefore, we compare the SARS-CoV-2-reactive responses in moderate, severe, critical patients unexposed donors. Overlapping peptide pools of all three induce response with dominance CD4+ over CD8+ cells demonstrate interindividual against proteins. M-protein induces highest frequencies cells, suggesting its relevance for diagnosis vaccination. The is robust comparable or...
Abstract Objective To assess whether reshaping of the immune balance by infusion autologous natural regulatory T cells (nTregs) in patients after kidney transplantation is safe, feasible, and enables tapering lifelong high dose immunosuppression, with its limited efficacy, adverse effects, direct indirect costs, along addressing several key challenges nTreg treatment, such as easy robust manufacturing, danger over interaction standard care drugs, functional stability an inflammatory...
Abstract All memory T cells mount an accelerated response on antigen reencounter, but significant functional heterogeneity is present within the respective T-cell subsets as defined by CCR7 and CD45RA expression, thereby warranting further stratification. Here we show that several surface markers, including KLRB1, KLRG1, GPR56, KLRF1, help define low, high, or exhausted cytokine producers human peripheral intrahepatic CD4 + populations. Highest simultaneous production of TNF IFN-γ observed...
SARS-CoV-2 variants of concern (VOCs) can trigger severe endemic waves and vaccine breakthrough infections (VBI). We analyzed the cellular humoral immune response in 8 patients infected with alpha variant, resulting moderate to fatal COVID-19 disease manifestation, after double mRNA-based anti-SARS-CoV-2 vaccination. In contrast uninfected vaccinated control cohort, diseased individuals had no detectable high-avidity spike (S)-reactive CD4+ CD8+ T cells against variant wild type (WT) at...
BACKGROUNDThe fungus Aspergillus fumigatus causes a variety of clinical phenotypes in patients with cystic fibrosis (pwCF). Th cells orchestrate immune responses against fungi, but the types A. fumigatus-specific pwCF and their contribution to protective immunity or inflammation remain poorly characterized.METHODSWe used antigen-reactive T cell enrichment (ARTE) investigate fungus-reactive peripheral blood healthy controls.RESULTSWe show that clonally expanded, high-avidity effector cells,...
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) preferentially affects epithelia of the upper and lower tract. Thus, impairment kidney function has been primarily attributed until now to secondary effects such as cytokine release or fluid balance disturbances. We provide evidence that SARS-CoV-2 can directly infiltrate a allograft. A 69-year-old male, who underwent pancreas-kidney transplantation 13 years previously, presented our hospital with coronavirus disease 2019...
Abstract Background The efficacy of the humoral and cellular immunity determines outcome viral infections. An appropriate immune response mediates protection, whereas an overwhelming has been associated with immune-mediated pathogenesis in current study explored general SARS-CoV-2 specific status patients different COVID-19 severities. Methods In this prospective study, we included 53 moderate, severe, critical manifestations comparing their quantitative, phenotypic, functional...
Activity of the CXCR3alt-CXCL11 chemokine system in CD8 + stem-like T cells predicts chemotherapy response patients with bladder cancer.