A5037283048- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Polyomavirus and related diseases
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Parvovirus B19 Infection Studies
- Viral-associated cancers and disorders
- Full-Duplex Wireless Communications
- Acute Kidney Injury Research
- Blood Pressure and Hypertension Studies
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Fibromyalgia and Chronic Fatigue Syndrome Research
- COVID-19 Impact on Reproduction
- vaccines and immunoinformatics approaches
- Sepsis Diagnosis and Treatment
- Complement system in diseases
- Nutrition and Health in Aging
- Organ Transplantation Techniques and Outcomes
- Immune responses and vaccinations
- Hemodynamic Monitoring and Therapy
- Hepatitis B Virus Studies
Universitätsklinik Marien Hospital Herne
2016-2025
Ruhr University Bochum
2016-2025
Humboldt-Universität zu Berlin
2003-2025
Charité - Universitätsmedizin Berlin
2016-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2018-2025
Freie Universität Berlin
2015-2025
University Hospitals of the Ruhr-University of Bochum
2018-2025
LWL-Universitätsklinikum Bochum
2018-2024
University of Duisburg-Essen
2023
Berlin-Brandenburger Centrum für Regenerative Therapien
2011-2021
Abstract Here, we report an update of the VDJdb database with a substantial increase in number T-cell receptor (TCR) sequences and their cognate antigens. The further provides new infrastructure featuring two additional analysis modes that facilitate querying real-world data analysis. increased yield TCR specificity identification methods overall studies field has allowed us to expand more than 5-fold. Furthermore, several are included. For example, batch annotation repertoire sequencing...
Dialysis and kidney transplant patients are vulnerable populations for COVID-19 related disease mortality.
T cell immunity toward SARS-CoV-2 spike (S-), membrane (M-), and nucleocapsid (N-) proteins may define COVID-19 severity. Therefore, we compare the SARS-CoV-2-reactive responses in moderate, severe, critical patients unexposed donors. Overlapping peptide pools of all three induce response with dominance CD4+ over CD8+ cells demonstrate interindividual against proteins. M-protein induces highest frequencies cells, suggesting its relevance for diagnosis vaccination. The is robust comparable or...
Abstract Objective To assess whether reshaping of the immune balance by infusion autologous natural regulatory T cells (nTregs) in patients after kidney transplantation is safe, feasible, and enables tapering lifelong high dose immunosuppression, with its limited efficacy, adverse effects, direct indirect costs, along addressing several key challenges nTreg treatment, such as easy robust manufacturing, danger over interaction standard care drugs, functional stability an inflammatory...
Objectives The RNA virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for disease 2019 (COVID-19). Cell entry mediated by the human angiotensin-converting enzyme II (ACE2). ACE2 and its close homolog I ( ACE ) are currently discussed candidate genes, in which single-nucleotide polymorphisms (SNPs) could alter binding or of SARS-CoV-2 enhance tissue damage lung other organs. This increase susceptibility infection severity COVID-19. Patients methods We performed...
Impaired BKV-specific immunity is associated with development of BKV-associated nephropathy. Suitable immunological parameters to identify patients at risk, however, are still debated. We monitored 18 kidney-transplant recipients through the course self-limited BKV-reactivation (n = 11) and nephropathy 7). cellular directed nonstructural small Large T-antigen, structural VP1-3 was analyzed in an interferon-γ Elispot assay. IgM IgG were measured using enzyme-linked immunosorbent assay...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell response that most likely contributes to virus control in COVID-19 patients but may also induce immunopathology. Until now, the cytotoxic has not been very well characterized patients. Here, we analyzed differentiation and profile of cells 30 cases mild during infection. SARS-CoV-2 induced CD8+ cells, CD4+ by simultaneous production granzyme A B as perforin within different effector subsets....
Mucosal-associated invariant T (MAIT) cells are characterized by an TCRVα7.2 chain recognizing microbial vitamin B metabolites presented the MHC-Ib molecule MR1. They mainly detectable in CD8(+) and CD8(-) CD4(-) "double negative" T-cell compartments of mammals exhibit both Th1- Th17-associated features. As MAIT show a tissue-homing phenotype operate at mucosal surfaces with myriads pathogenic encounters, we wondered how IL-15, multifaceted cytokine being part intestinal barrier, impacts on...
Abstract Immunological competence declines progressively with age, resulting in increased susceptibility of the elderly to infection and impaired responses vaccines. Underlying mechanisms remain largely obscure as they have been related complex, individual systemic immune properties that are challenging investigate. In this study, we explored age-related changes human immunity during a primary virus experimentally induced by immunization live-attenuated yellow fever (YF) vaccine. Applying...
Abstract Motivation: Recombined T- and B-cell receptor repertoires are increasingly being studied using next generation sequencing (NGS) in order to interrogate the repertoire composition as well changes distribution of clones under different physiological disease states. This type analysis requires efficient unambiguous clonotype assignment a large number NGS read sequences, including identification incorporated V J gene segments CDR3 sequence. Current tools have deficits with respect...
Prevention and therapy of immunothrombosis remain crucial challenges in the management coronavirus disease 2019, since underlying mechanisms are incompletely understood. We hypothesized that endothelial damage may lead to substantially increased concentrations von Willebrand factor with subsequent relative deficiency a disintegrin metalloproteinase thrombospondin type 1 motif, member 13 (ADAMTS13).Prospective controlled cross-over trial.Blood samples patients confirmed 2019 healthy controls...
Autoreactive antibodies (AAB) are currently being investigated as causative or aggravating factors during post-COVID. In this study we analyze the effect of immunoadsorption therapy on symptom improvement and relationship with immunological parameters in post-COVID patients exhibiting symptoms Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) induced aggravated by an SARS-CoV-2 infection. This observational includes 12 a predominance ME/CFS alongside increased concentrations...
BKV reactivation plays the causative role in development of BKV-associated nephropathy (BKVAN). Because lack effective therapy, early diagnosis is paramount for prevention BKVAN. Resting uroepithelial cells, excreted first urine before it can be detected plasma. The present study analyzed predictive value BK viruria viremia and its possible advantage BKVAN prediction.Total 4128 serum samples obtained from renal transplant patients were positivity by real-time polymerase chain reaction 433...