A5050849561- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Long-Term Effects of COVID-19
- T-cell and B-cell Immunology
- Animal Virus Infections Studies
- Poxvirus research and outbreaks
- Cancer Immunotherapy and Biomarkers
- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- Education and Character Development
- Cytomegalovirus and herpesvirus research
- Macrophage Migration Inhibitory Factor
University of Duisburg-Essen
2020-2023
Institute of Virology of the Slovak Academy of Sciences
2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell response that most likely contributes to virus control in COVID-19 patients but may also induce immunopathology. Until now, the cytotoxic has not been very well characterized patients. Here, we analyzed differentiation and profile of cells 30 cases mild during infection. SARS-CoV-2 induced CD8+ cells, CD4+ by simultaneous production granzyme A B as perforin within different effector subsets....
Abstract SARS-CoV-2 infection induces a T cell response that most likely contributes to virus control in COVID-19 patients, but may also induce immunopathology. Until now, the cytotoxic has not been very well characterized patients. Here, we analyzed differentiation and profile of cells 30 cases mild during acute infection. induced CD8+ cells, CD4+ by simultaneous production granzyme A B, as perforin within different effector subsets. PD-1 expressing produced molecules indicating they were...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused millions of COVID-19 cases and deaths worldwide. Severity pulmonary pathologies poor prognosis were reported to be associated with the activation non-virus-specific bystander T cells. In addition, high concentrations macrophage migration inhibitory factor (MIF) found in serum patients. We hypothesized that these two pathogenic factors might related analyzed expression receptors for MIF on cells COVID-19. from PBMCs...
Type I interferons (IFNs) present the first line of defense against viral infections, providing antiviral, immunomodulatory and antiproliferative effects. The type IFN family contains 12 IFNα subtypes IFNβ, although they share same receptor, are classified as non-redundant, capable to induce a variety different IFN-stimulated genes. However, biological impact individual remains controversial. Recent data propose subtype-specificity IFNs revealing unique effector functions for viruses thus...
Antiviral immunity often requires CD8+ cytotoxic T lymphocytes (CTLs) that actively migrate and search for virus-infected targets. Regulatory cells (Tregs) have been shown to suppress CTL responses, but it is not known whether this also mediated by effects on motility. Here, we used intravital 2-photon microscopy in the Friend retrovirus (FV) mouse model define impact of Tregs motility throughout course acute infection. Virus-specific CTLs were very motile had frequent short contacts with...
Specific CD8+ T cells are crucial for the control of viruses. However, during many chronic viral infections these become dysfunctional. Immune checkpoint receptors, like PD-1 expressed on cells, contribute to this functional suppression infection. acute phase infection virus-specific express high levels but fully competent in killing virus-infected and there is increasing evidence that biological activity inhibitory receptors strongly influenced by availability their respective ligands. We...