A5027386050- Cardiovascular Health and Disease Prevention
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- CAR-T cell therapy research
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Immune Cell Function and Interaction
- Cardiovascular and exercise physiology
- Cerebrovascular and Carotid Artery Diseases
- Adipose Tissue and Metabolism
- T-cell and B-cell Immunology
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Urban Heat Island Mitigation
- Hormonal and reproductive studies
- Adipokines, Inflammation, and Metabolic Diseases
- Sexual function and dysfunction studies
- Obesity, Physical Activity, Diet
- Urban Green Space and Health
- Aortic Disease and Treatment Approaches
- Cardiac electrophysiology and arrhythmias
- Diabetes Treatment and Management
- Transplantation: Methods and Outcomes
- Transgenic Plants and Applications
- Diet and metabolism studies
Charité - Universitätsmedizin Berlin
2013-2023
Freie Universität Berlin
2022
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2020-2022
Humboldt-Universität zu Berlin
2019-2022
Brandenburg University of Applied Sciences
2019
Novartis Institutes for BioMedical Research
2012-2017
Novartis (Switzerland)
2012-2017
German Center for Diabetes Research
2015
German Institute of Human Nutrition
2010-2015
Greatbatch (United States)
2014
Abstract Objective To assess whether reshaping of the immune balance by infusion autologous natural regulatory T cells (nTregs) in patients after kidney transplantation is safe, feasible, and enables tapering lifelong high dose immunosuppression, with its limited efficacy, adverse effects, direct indirect costs, along addressing several key challenges nTreg treatment, such as easy robust manufacturing, danger over interaction standard care drugs, functional stability an inflammatory...
Caloric restriction and intermittent fasting are known to improve glucose homeostasis insulin resistance in several species including humans. The aim of this study was unravel potential mechanisms by which these interventions sensitivity protect from type 2 diabetes. Diabetes-susceptible New Zealand Obese mice were either 10% calorie restricted (CR) or fasted every other day (IF), compared ad libitum (AL) fed control mice. AL showed a diabetes prevalence 43%, whereas under CR IF completely...
Background —–The effects of smooth muscle relaxation on arterial wall mechanics are controversial. We used a new, in vivo, noninvasive technique to measure brachial artery under baseline conditions and following with nitroglycerin (NTG). Methods Results —Eight healthy, normal subjects (6 male, 2 female; age 30±3.1 years) participated the study. The nondominant was imaged through water-filled blood pressure cuff using an external ultrasound wall-tracking system at 0.4 mg sublingual NTG....
Abstract Objective: The objective was to examine cardiovascular autonomic (cANS) function and its potential relationships with leptin resistance, insulin oxidative stress, inflammation in a pediatric sample varying levels of obesity. Research Methods Procedures: Participants were normal‐weight (NW; BMI <85th percentile, 6 male, 4 female), overweight (OW; 85th percentile < <95th obese children (OB; >95th 10 female) who had cANS assessed via heart rate variability (HRV) methods...
Carbohydrate-free diet prevents hyperglycaemia and beta cell destruction in the New Zealand Obese (NZO) mouse model. Here we have used a sequential dietary regimen to dissociate effects of obesity on function integrity, study glucose-induced alterations key transcription factors over 16 days.Mice were rendered obese by feeding carbohydrate-free for 18 weeks. Thereafter, carbohydrate-containing was given. Plasma glucose, plasma insulin total pancreatic determined, forkhead box O1 protein...
Abstract —Compliance, distensibility, incremental elastic modulus (E inc ), and pulse wave velocity are all terms used to describe the mechanical properties of arteries. Previous studies assessing effects smooth muscle relaxation on each these parameters have produced conflicting results. Our laboratory has previously demonstrated that intrabrachial infusion nitroglycerin in normal human subjects results a large increase brachial artery compliance without changing arterial wall stiffness as...
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is essential for immune responses triggered by antigen receptors but the contribution of its paracaspase activity not fully understood. Here, we studied how MALT1 proteolytic function regulates T-cell activation and fate after engagement receptor pathway. We show that MLT-827, a potent selective inhibitor, does prevent initial phase activation, in contrast to pan-protein kinase C inhibitor AEB071. However, MLT-827...
Graft-versus-host disease (GvHD) is still the major non-relapse, life-limiting complication after hematopoietic stem cell transplantation. Modern pharmacologic immunosuppression often insufficient and associated with significant side effects. Novel treatment strategies now include adoptive transfer of <i>ex vivo</i> expanded regulatory T cells (Tregs), but their efficacy in chronic GvHD unknown. We treated three children suffering from severe, therapy-refractory polyclonally Tregs generated...
Data suggest that carvedilol possesses antioxidant properties might provide vascular protection. We sought to compare the effects of and metoprolol tartrate on endothelial function oxidative stress in a head-to-head trial.Thirty-four patients with type 2 diabetes mellitus (T2DM) hypertension were randomized receive either (n = 16) or 18) addition their current antihypertensive medications for 5 months. The following variables measured pre- posttreatment: blood pressure, fasting glucose...
Peptide hormones are powerful regulators of various biological processes. To guarantee continuous availability and function, peptide hormone secretion must be tightly coupled to its biosynthesis. A simple but efficient way provide such regulation is through an autocrine feedback mechanism in which the secreted “sensed” by respective receptor initiates synthesis at level transcription and/or translation. Such a secretion–biosynthesis coupling has been demonstrated for insulin; however,...
Urban environments are characterized by dense development and paved ground with reduced evapotranspiration rates. These areas store sensible latent heat, providing the base for typical urban heat island effects. Green roof installations one possible strategy to reintroduce evaporative surfaces into cities. If green roofs irrigated, they can contribute water management be enhanced. As part of two research projects, lysimeter measurements were used determine real rates on University Applied...
We compared the vascular effects of rosiglitazone versus glyburide and evaluated asymmetric dimethylarginine (ADMA) oxidative stress as potential mechanisms associated with changes in health patients type 2 diabetes mellitus (T2DM). Patients were randomized to 6 months either (n = 20) or 16) addition metformin. The following variables measured pre- post-treatment: glucose, insulin, homeostasis model assessment (HOMA), hemoglobin A1c (HbA1c), C-peptide, blood pressure, lipids, C-reactive...
Phosphodiesterase-5 (PDE-5) inhibitors are an effective therapy for the majority of men with erectile dysfunction (ED). However, many ED still report a suboptimal or partial response even after adequate trial oral PDE-5 therapy. Since is associated impaired vascular function and both atorvastatin quinapril have been previously shown to improve function, we examined effects adjunctive treatment these medications in vasculogenic who were responders 100 mg sildenafil. Men sildenafil randomly...
Thirty‐four children were assessed for body composition, blood pressure, lipids, glucose tolerance, markers of insulin resistance, oxidative stress, and adipokines. Children divided into 3 groups: (1) normal weight, (2) overweight but otherwise healthy, (3) with the metabolic syndrome. There no differences among any groups age or Tanner stage, anthropometric variables similar between syndrome groups. Differences across found high‐density lipoprotein cholesterol ( P <.001), triglycerides...
Approximately 10 km2 of new green roofs are built in Germany every year. About 85% these Extensive Green Roofs (EGR). An EGR with several research features was installed on buildings belonging to the University Applied Sciences Neubrandenburg 1999. The results almost 20-year permanent survey climate effects roof contrast gravel presented here. High-quality sensors, similar those used by official weather stations, use, and data is collected s aggregated hourly values which enable comparisons...