A5020583846- Cutaneous lymphoproliferative disorders research
- Fungal Infections and Studies
- T-cell and Retrovirus Studies
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Nail Diseases and Treatments
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Toxin Mechanisms and Immunotoxins
- Chemotherapy-related skin toxicity
- Actinomycetales infections and treatment
- Mycobacterium research and diagnosis
- HIV-related health complications and treatments
- Ion Channels and Receptors
- HIV Research and Treatment
- Musculoskeletal pain and rehabilitation
- Cytomegalovirus and herpesvirus research
- Infectious Diseases and Mycology
German Center for Neurodegenerative Diseases
2023
University of Copenhagen
2016-2022
LEO Foundation
2019-2022
Society for Neuroscience
2017
Abstract Cutaneous T-cell lymphoma (CTCL) is a devastating lymphoid malignancy characterized by the accumulation of malignant T cells in dermis and epidermis. Skin lesions cause serious symptoms that hamper quality life are entry sites for bacterial infection, major morbidity mortality advanced diseases. The mechanism driving pathological processes compromise skin barrier remains unknown. Here, we report increased transepidermal water loss compromised expression proteins filaggrin...
Abstract Itch is a sensation that promotes the desire to scratch, which can be evoked by mechanical and chemical stimuli. In spinal cord, neurons expressing gastrin-releasing peptide receptor (GRPR) have been identified as specific mediators of itch. However, our understanding GRPR population in thus how these exercise their functions, limited. For this purpose, we constructed Cre line designed target (Grpr-Cre). Our analysis revealed Grpr-Cre cells cord are predominantly excitatory...
// Lise M. Lindahl 1 , Simon Fredholm 2 Claudine Joseph Boye Schnack Nielsen 3 Lars Jønson 4 Andreas Willerslev-Olsen Maria Gluud Edda Blümel David L. Petersen Nina Sibbesen Tengpeng Hu Claudia Nastasi Thorbjørn Krejsgaard Ditte Jæhger Jenny Persson 5 Nigel Mongan 6 Mariusz A. Wasik 7 Ivan V. Litvinov 8 Denis Sasseville 9 Sergei B. Koralov 10 Charlotte Bonefeld Carsten Geisler Anders Woetmann Elisabeth Ralfkiaer 11 Iversen Niels Odum Department of Dermatology, Aarhus...
Staphylococcus aureus is implicated in disease progression cutaneous T-cell lymphoma (CTCL). Here, we demonstrate that malignant T cell lines derived from CTCL patients as well primary CD4+ cells Sézary syndrome are considerably more resistant to alpha-toxin-induced death than their non-malignant counterparts. Thus, a subset of the ratio between and increases significantly following exposure alpha-toxin. Whereas toxin-induced ADAM10 dependent healthy cells, resistance alpha-toxin involves...
Staphylococcus aureus and its toxins have been linked to disease progression mortality in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8+ T cells play a crucial role anti-cancer responses high cell numbers tumor lesions are associated with favorable prognosis CTCL. Here, we show that from both healthy donors Sézary syndrome patients highly susceptible death induced by Staphylococcal alpha-toxin, whereas malignant not. Importantly, alpha-toxin almost completely blocks cytotoxic...
Sézary syndrome (SS) is a heterogeneous leukemic subtype of cutaneous T-cell lymphoma (CTCL) with generalized erythroderma, lymphadenopathy, and poor prognosis. Advanced disease invariably associated severe immune dysregulation the majority patients die from infectious complications caused by microorganisms such as, Staphylococcus aureus, rather than per se. Here, we examined if staphylococcal enterotoxins (SE) may shape phenotype malignant SS cells, including expression regulatory...
Introduction People living with HIV (PLHIV) are characterized by functional reprogramming of innate immune cells even after long-term antiretroviral therapy (ART). In order to assess technical feasibility omics technologies for application larger cohorts, we compared multiple data layers. Methods Bulk and single-cell transcriptomics, flow cytometry, proteomics, chromatin landscape analysis ATAC-seq as well ex vivo drug stimulation were performed in a small number blood samples derived from...
Severe postoperative wound infections caused by Nocardia farcinica were repeatedly observed in a German hospital surgical ward. A pulsed-field gel electrophoresis (PFGE) protocol was established to characterize the genetic relatedness of bacterial isolates from these infections. All 18 that have occurred since 1985 belong common endemic genotype; organisms this genotype also detected air two rooms department where occurred. In contrast, environmental another building on same campus showed...
Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL), is a lymphoproliferative disorder characterized by proliferation malignant T cells in chronic inflammatory environment skin. The nature MF still not fully understood, but aberrant microRNA (miR) expression and function seem to play an important role pathogenesis disease progression have been proposed as putative marker. Recent studies reported miR-93 situin lesions linked dysregulated advanced stages MF....
The voltage-gated potassium channel Kv1.3 (KCNA3) is expressed by a subset of chronically activated memory T cells and plays an important role in their activation proliferation. Here, we show that primary malignant isolated from patients with Sézary syndrome (SS) express are sensitive to potent inhibitors ShK Vm24, but not less inhibitor [N17A/F32T]-AnTx. blockade inhibits CD3/CD28-induced proliferation IL-9 expression SS concentration-dependent manner. In parallel, CD3/CD28-mediated CD25...
<b><i>Background:</i></b> The voltage-gated potassium channel Kv1.3 (KCNA3) is expressed by effector memory T cells (T<sub>EM</sub>) and plays an important role in their activation proliferation. Mycosis fungoides (MF), the most common subtype of cutaneous T-cell lymphoma (CTCL), was recently proposed to be a malignancy skin-resident T<sub>EM</sub>. However, expression CTCL has not been investigated....