A5086573412- Ion Channels and Receptors
- Neurobiology and Insect Physiology Research
- Pain Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Mitochondrial Function and Pathology
- Nerve injury and regeneration
- Axon Guidance and Neuronal Signaling
- Dermatology and Skin Diseases
- Advanced Glycation End Products research
- Stress Responses and Cortisol
- Zebrafish Biomedical Research Applications
- Circadian rhythm and melatonin
- Antibiotic Resistance in Bacteria
- Asthma and respiratory diseases
- Mast cells and histamine
- Adipose Tissue and Metabolism
- Drug Transport and Resistance Mechanisms
- Biochemical Analysis and Sensing Techniques
- Bacterial Genetics and Biotechnology
- Exercise and Physiological Responses
- Gene Regulatory Network Analysis
- Neuroscience of respiration and sleep
- Allergic Rhinitis and Sensitization
- Muscle Physiology and Disorders
- High Altitude and Hypoxia
Uppsala University
2015-2024
Karolinska Institutet
2009-2022
Society for Neuroscience
2017
Institute of Molecular Biology and Biophysics
2013
University of Helsinki
2003-2005
Abstract Itch is a sensation that promotes the desire to scratch, which can be evoked by mechanical and chemical stimuli. In spinal cord, neurons expressing gastrin-releasing peptide receptor (GRPR) have been identified as specific mediators of itch. However, our understanding GRPR population in thus how these exercise their functions, limited. For this purpose, we constructed Cre line designed target (Grpr-Cre). Our analysis revealed Grpr-Cre cells cord are predominantly excitatory...
Transduction of pain following noxious stimuli is mediated by the activation specialized ion channels and receptors expressed nociceptive sensory neurons. A common early sublineage expressing nerve growth factor receptor TrkA diversifies into peptidergic non-peptidergic nociceptors around birth. In this process, neurons maintain expression, while downregulate upregulate glial-derived neurotrophic family ligand Ret bind isolectin B4 (IB4). Although can have profound impacts on molecular...
Carotid body glomus cells mediate essential reflex responses to arterial blood hypoxia. They are dopaminergic and secrete growth factors that support neurons, making the carotid a potential source of patient-specific for Parkinson's disease therapy. Like adrenal chromaffin cells, which also hypoxia-sensitive, neural crest-derived require transcription Ascl1 Phox2b; otherwise, their development is little understood at molecular level. Here, analysis in chicken mouse reveals further striking...
Methylglyoxal and synthetic glyoxal derivatives react covalently with arginine residue(s) on the mitochondrial permeability transition pore (PTP). In this study, we have investigated how binding of a panel phenylglyoxal influences opening closing PTP. Using both isolated mitochondria mammalian cells, demonstrate that resulting arginine-phenylglyoxal adduct can lead to either suppression or induction transition, depending net charge hydrogen bonding capacity adduct. We report possess negative...
The principle by which unmyelinated primary sensory neurons transducing thermal, itch and pain perception are specified in early development is unknown. These classes of diversify from a common population late-born neurons, initiate expression Runt homology domain transcription factor RUNX1 the nerve growth receptor TrkA. Here, we report that signals emanating within mouse dorsal root ganglion mediated partly early-born destined to myelinated phenotype participate fating + /TrkA neurons....
Allergic reactions can in severe cases induce a state of circulatory shock referred to as anaphylaxis. Histamine, the primary mediator this condition, is released from immune cells, and, therefore, anaphylaxis has so far been considered an system disorder. However, we here show that glutamatergic receptor mGluR7, expressed on subpopulation both peripheral and spinal cord neurons, controls histamine-induced communication through calcium-dependent autoinhibition with implications for Genetic...
Abstract In the spinal cord, sensory‐motor circuits controlling motor activity are situated in dorso–ventral interface. The neurons identified by expression of transcription factor Doublesex and mab‐3 related 3 (Dmrt3) have previously been associated with coordination locomotion horses ( Equus caballus , Linnaeus, 1758), mice Mus musculus zebrafish Danio rerio F. Hamilton, 1822). Based on earlier studies, we hypothesized that, mice, these may be positioned to receive sensory central inputs...
Abstract Urocortin 3 is a neuropeptide that belongs to the corticotropin-releasing hormone family and involved in mechanosensation stress regulation. In this study, we show marks population of excitatory neurons mouse spinal cord, divided into 2 nonoverlapping subpopulations expressing protein kinase C gamma or calretinin/calbindin 2, populations previously associated with mechanosensation. Electrophysiological experiments demonstrated lumbar receive both glycinergic GABAergic local tonic...