A5033314673- Gastrointestinal motility and disorders
- Clinical Nutrition and Gastroenterology
- Ion Channels and Receptors
- Helicobacter pylori-related gastroenterology studies
- RNA Research and Splicing
- Pain Mechanisms and Treatments
- Eosinophilic Esophagitis
- Cellular transport and secretion
- Axon Guidance and Neuronal Signaling
- Nasal Surgery and Airway Studies
- Cellular Mechanics and Interactions
- Mitochondrial Function and Pathology
- Congenital gastrointestinal and neural anomalies
- Developmental Biology and Gene Regulation
- interferon and immune responses
- Nerve injury and regeneration
- ATP Synthase and ATPases Research
- Neurobiology and Insect Physiology Research
- Congenital Ear and Nasal Anomalies
- Lung Cancer Research Studies
- Peroxisome Proliferator-Activated Receptors
- Neuroscience of respiration and sleep
- Ginger and Zingiberaceae research
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
IFOM
2022-2024
Molecular Oncology (United States)
2024
Karolinska Institutet
2011-2019
Inserm
2009-2012
Nantes Université
2009-2012
PhysioPathologie des Adaptations Nutritionnelles
2009-2010
Centre Hospitalier Universitaire de Nantes
2009
Following the yellow brick road The adrenal glands affect a variety of processes such as stress responses and metabolism. mature gland is formed from multiple tissue sources, including cells neural origin. Furlan et al. traced origins these cells. first become Schwann cell precursors follow along nerves to travel dorsal root ganglia spine gland. Once there, differentiate into chromaffin authors used singlecell transcriptomics reveal shifts in functional programs during migration,...
An essential prerequisite for the survival of an organism is ability to detect and respond aversive stimuli. Current belief that noxious stimuli directly activate nociceptive sensory nerve endings in skin. We discovered a specialized cutaneous glial cell type with extensive processes forming mesh-like network subepidermal border skin conveys thermal mechanical sensitivity. demonstrate direct excitatory functional connection neurons provide evidence previously unknown organ has physiological...
Nociception is protective and prevents tissue damage but can also facilitate chronic pain. Whether a general principle governs these two types of pain unknown. Here, we show that both basal mechanical neuropathic are controlled by the microRNA-183 (miR-183) cluster in mice. This single controls more than 80% pain-regulated genes scales sensitivity allodynia regulating auxiliary voltage-gated calcium channel subunits α2δ-1 α2δ-2. Basal nociceptors, involves TrkB+ light-touch mechanoreceptors....
Abstract The process in which locally confined epithelial malignancies progressively evolve into invasive cancers is often promoted by unjamming, a phase transition from solid-like to liquid-like state, occurs various tissues. Whether this tissue-level mechanical impacts phenotypes during carcinoma progression remains unclear. Here we report that the large fluctuations cell density accompany unjamming result repeated deformations of cells and nuclei. This triggers cellular mechano-protective...
Enteric glial cells (EGCs) are essential in the control of gastrointestinal functions. Although lesions EGCs associated with neuronal degeneration animal models, their direct neuroprotective role remains unknown. Therefore, aims this study were to demonstrate effects and identify putative mediators involved. First, viral targeted ablation primary cultures enteric nervous system increased death both under basal conditions presence oxidative stress (dopamine, hydrogen peroxide). Second, or...
The enteric nervous system (ENS) and its major component, glial cells (EGCs), have recently been identified as a regulator of intestinal epithelial barrier functions. Indeed, EGCs inhibit cell (IEC) proliferation increase resistance IEC adhesion via the release EGC-derived soluble factors. Interestingly, EGC regulation functions is reminiscent previously reported peroxisome proliferator-activated receptor gamma (PPARgamma)-dependent functional effects. In this context, present study aimed at...
Increasing evidence suggests that enteric glial cells (EGCs) are critical for neuron survival and functions. In particular, EGCs exert direct neuroprotective effects mediated in part by the release of glutathione. However, other factors such as those identified regulating intestinal epithelial barrier particular omega-6 fatty acid derivative 15-deoxy-Δ¹²,¹⁴-prostaglandin J2 (15d-PGJ2) could also be involved EGC-mediated neuroprotection. Therefore, our study aimed to assess putative role...
Facial shape is the basis for facial recognition and categorization. features reflect underlying geometry of skeletal structures. Here, we reveal that cartilaginous nasal capsule (corresponding to upper jaw face) shaped by signals generated neural structures: brain olfactory epithelium. Brain-derived Sonic Hedgehog (SHH) enables induction septum posterior capsule, whereas formation a roof controlled from Unexpectedly, cartilage turned out be important shaping membranous bones during...
Abstract Touch sensation is mediated by specific subtypes of sensory neurons which develop in a hierarchical process from common early progenitor neurons, but the molecular mechanism that underlies diversification touch‐sensitive mechanoreceptive not fully known. Here, we use genetically manipulated mice to examine whether transcription factor short stature homeobox 2 (Shox2) participates acquisition neuronal conveying touch sensation. We show Shox2 encodes development category I...
Abstract One open question in the biology of growth factor receptors is how a quantitative input (i.e., ligand concentration) decoded by cell to produce specific response(s). Here, we show that an EGFR endocytic mechanism, non-clathrin endocytosis (NCE), which activated only at high concentrations and targets receptor degradation, requires tripartite organelle platform involving plasma membrane (PM), endoplasmic reticulum (ER) mitochondria. At these contact sites, EGFR-dependent,...
Abstract Increased extracellular matrix (ECM) and stiffness promote solid tumor progression. However, mechanotransduction in cancers arising mechanically active tissues remains underexplored. Here, we report upregulation of multiple ECM components accompanied by tissue stiffening vocal fold cancer (VFC). We compare non-cancerous (NC) patient- derived VFC cells – from early (mobile, T1) to advanced-stage (immobile, T3) revealing an association between progression cell-surface receptor...
Current textbooks teach that adrenergic chromaffin cells of the adrenal medulla originate from a sympathoadrenal cell lineage neural crest nearby dorsal aorta. Here, Furlan et al. demonstrate novel origin these neuroendocrine arising predominantly Schwamm precursors (SCP) peripheral nerves. Previously it had been shown SCPs serve as multipotent stem can differentiate into various types, most importantly parasympathetic nerve cells. Using genetic fate tracing, SCP and ablation, well...
Touch and mechanical sensations require the development of several different kinds sensory neurons dedicated to respond certain types stimuli. The transcription factor Shox2 (short stature homeobox 2) is involved in generation TRKB+ low-threshold mechanoreceptors (LTMRs), but mechanisms terminating this program allowing alternative fates are unknown. Here, we show that conditional loss miR-183-96-182 cluster mouse leads a failure extinction during an increase proportion Aδ LTMRs...
Abstract One open question in the biology of growth factor receptors is how a quantitative input ( i.e., ligand concentration) decoded by cell to produce specific response(s). Here, we show that an EGFR endocytic mechanism, non-clathrin endocytosis (NCE), which activated only at high concentrations and targets receptor degradation, requires tripartite organelle platform involving plasma membrane (PM), endoplasmic reticulum (ER) mitochondria. At these contact sites, EGFR-dependent,...