A5077471996- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Developmental Biology and Gene Regulation
- Osteoarthritis Treatment and Mechanisms
- Connective tissue disorders research
- Lipid metabolism and biosynthesis
- Bone Metabolism and Diseases
- Muscle metabolism and nutrition
- Proteoglycans and glycosaminoglycans research
- Genital Health and Disease
- Fibroblast Growth Factor Research
- Cellular Mechanics and Interactions
- Hedgehog Signaling Pathway Studies
- Pleural and Pulmonary Diseases
- interferon and immune responses
- Health Systems, Economic Evaluations, Quality of Life
- Ultrasound in Clinical Applications
- Genetics, Aging, and Longevity in Model Organisms
- Nasal Surgery and Airway Studies
- Kruppel-like factors research
- Immune Cell Function and Interaction
- Clinical practice guidelines implementation
- Lung Cancer Diagnosis and Treatment
- FOXO transcription factor regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Karolinska Institutet
2016-2025
Peking University
2023-2025
Chinese Institute for Brain Research
2024-2025
Center for Life Sciences
2025
McGovern Institute for Brain Research
2023-2024
King University
2024
Hebei Medical University
2024
Fourth Hospital of Hebei Medical University
2024
Hunan International Economics University
2024
Jamaica Hospital
2020-2021
Articular cartilage has little regenerative capacity. Recently, genetic lineage tracing experiments have revealed chondrocyte progenitors at the articular surface. We further characterized these by using in vivo approaches. Histone H2B-green fluorescent protein retention that superficial cells divide more slowly than underlying chondrocytes. Clonal combined with immunohistochemistry renew their number symmetric division, express mesenchymal stem cell markers, and generate chondrocytes via...
Facial shaping results from oriented divisions and crowd movements of ectomesenchymal cells during morphogenetic events.
Significance Multipotent Schwann cell precursors (SCPs) generate numerous types. Here, in both mouse and zebrafish, SCPs contributed to the generation of mesenchymal, chondroprogenitor, osteoprogenitor cells during embryonic development. These findings reveal a source cartilage bone previously unanticipated interactions between nervous system skeleton
Approaches are needed to better delineate the continuum of opioid misuse that occurs in hospitalized patients. A prognostic enrichment strategy with latent class analysis (LCA) may facilitate treatment strategies subtypes misuse. We aim identify patients and examine distinctions between by examining patient characteristics, topic models from clinical notes, outcomes.This was an observational study inpatient hospitalizations at a tertiary care center 2007 2017. Patients were identified using...
Assess patient outcomes in patients with suspected infection and the cost-effectiveness of implementing a quality improvement program.We conducted an observational single-center study 13,877 adults between March 1, 2014, July 31, 2017. The 18-month period before after effective date for mandated reporting sepsis bundle was examined. Sequential Organ Failure Assessment score culture antibiotic orders were used to identify meeting Sepsis-3 criteria from electronic health record.The following...
Growth plate and articular cartilage constitute a single anatomical entity early in development but later separate into two distinct structures by the secondary ossification center (SOC). The reason for such separation remains unknown. We found that evolutionarily SOC appears animals conquering land - amniotes. Analysis of pattern mammals with specialized extremities (whales, bats, jerboa) revealed correlates extent mechanical loads. Mathematical modeling reduces stress within growth plate....
Facial shape is the basis for facial recognition and categorization. features reflect underlying geometry of skeletal structures. Here, we reveal that cartilaginous nasal capsule (corresponding to upper jaw face) shaped by signals generated neural structures: brain olfactory epithelium. Brain-derived Sonic Hedgehog (SHH) enables induction septum posterior capsule, whereas formation a roof controlled from Unexpectedly, cartilage turned out be important shaping membranous bones during...
Perirenal adipose tissue (PRAT) is a unique visceral depot that contains mixture of brown and white adipocytes. The origin plasticity such cellular heterogeneity remains unknown. Here, we combine single-nucleus RNA sequencing with genetic lineage tracing to reveal the existence distinct subpopulation Ucp1 - & Cidea + adipocytes arises from brown-to-white conversion during postnatal life in periureter region mouse PRAT. Cold exposure restores expression thermogenic phenotype this...
The capacity of mature adipocytes to de-differentiate into fibroblast-like cells has been demonstrated in vitro and a few, rather specific vivo conditions. A detailed comparison between de-differentiated fat (DFAT) adipose stem progenitor (ASPCs) from different depots is yet be conducted. Moreover, whether de-differentiation classical subcutaneous visceral occurs under physiological conditions remains unknown. Here, we show that vitro-derived DFAT have lower adipogenic potential distinct...
Animals have developed diverse mechanisms to adapt their changing environment. Like many organisms the free-living nematode C. elegans can alternate between a reproductive mode or diapause-like "dauer" stage during larval development circumvent harsh environmental conditions. The master metabolic regulator AMP-activated protein kinase (AMPK) is critical for survival dauer stage, where it phosphorylates adipose triglyceride lipase (ATGL-1) at multiple sites block lipid hydrolysis and...
AMP-activated kinase (AMPK) is a key regulator of many cellular mechanisms required for adjustment to various stresses induced by the changing environment. In C. elegans dauer larvae AMPK-null mutants expire prematurely due hyperactive Adipose Triglyceride Lipase (ATGL-1) followed rapid depletion triglyceride stores. We found that compromise one three orthologues human cgi-58 significantly improves survival AMPK-deficient dauers. also provide evidence CGI-58 acts as co-activator ATGL-1,...
Genome-wide studies have identified three missense variants in the human gene ACVR1C, encoding TGF-β superfamily receptor ALK7, that correlate with altered waist-to-hip ratio adjusted for body mass index (WHR/BMI), a measure of fat distribution. To move from correlation to causation and understand effects these on accumulation adipose tissue function, we introduced each mouse Acvr1c locus investigated metabolic phenotypes comparison null mutation. Mice carrying I195T variant showed...
There are several pitfalls associated with research based on transgenic mice. Here, we describe our interpretation and analysis of mTORC1 activation in growth plate chondrocytes compare these to a recent publication (Yan et al., Nature Communications 2016, 7:11151). Both laboratories employed TSC1-floxed mice crossed collagen type 2-driven Cre (Col2-Cre), but drew substantially different conclusions. It was reported that mechanistic target rapamycin complex 1 (mTORC1) via Tsc1 ablation...
Perirenal adipose tissue (PRAT) is a unique visceral depot that contains mixture of brown and white adipocytes. The origin plasticity such cellular heterogeneity remains unknown. Here, we combine single-nucleus RNA sequencing with genetic lineage tracing to reveal the existence distinct subpopulation Ucp1-&Cidea+ adipocytes arises from brown-to-white conversion during postnatal life in periureter region mouse PRAT. Cold exposure restores Ucp1 expression thermogenic phenotype this...
The development of craniofacial skeletal structures is fascinatingly complex and elucidation the underlying mechanisms will not only provide novel scientific insights, but also help develop more effective clinical approaches to treatment and/or prevention numerous congenital malformations. To this end, we performed a genome-wide analysis RNA transcription from non-coding regulatory elements by CAGE-sequencing facial mesenchyme human embryos cross-checked active enhancers thus identified...