A5056391486- Gut microbiota and health
- Gastrointestinal motility and disorders
- Regulation of Appetite and Obesity
- Probiotics and Fermented Foods
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Infant Health and Development
- Estrogen and related hormone effects
- Cancer Immunotherapy and Biomarkers
- Asthma and respiratory diseases
- Pancreatic function and diabetes
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive System and Pregnancy
- Ion Channels and Receptors
- Mast cells and histamine
- Immune Response and Inflammation
- Digestive system and related health
- Immunotherapy and Immune Responses
- Protein Hydrolysis and Bioactive Peptides
- Eosinophilic Esophagitis
- Barrier Structure and Function Studies
Danone (France)
2019-2020
Inserm
2007-2019
The Enteric Nervous System in Gut and Brain Disorders
2019
Toxalim Research Centre in Food Toxicology
2012
PhysioPathologie des Adaptations Nutritionnelles
2009-2011
Nantes Université
2007-2011
NutriNeuro
2010
Institut National des Sciences Appliquées de Toulouse
2005-2006
Neonatal maternal deprivation (NMD) increases gut paracellular permeability (GPP) through mast cells and nerve growth factor (NGF), modifies corticotrophin‐releasing (CRF) corticosterone levels. CRF, are involved in stress‐induced mucosal barrier impairment. Consequently, this study aimed to specify whether corticosteronaemia colonic expression of both preproCRF CRF modified by NMD, determine if altered may participate the elevated GPP connection with NGF cells. Male Wistar rat pups were...
Nutritional factors can induce profound neuroplastic changes in the enteric nervous system (ENS), responsible for gastrointestinal (GI) motility. However, long-term effects of a nutritional imbalance leading to obesity, such as Western diet (WD), upon ENS phenotype and control GI motility remain unknown. Therefore, we investigated WD-induced obesity (DIO) on function well involved functional plasticity. Mice were fed with normal (ND) or WD 12 weeks. was assessed vivo ex vivo. Myenteric...
Colonic transit and mucosal integrity are believed to be impaired in obesity. However, a comprehensive assessment of altered colonic functions, inflammatory changes neuronal signalling obese animals is missing. In mice, we studied the impact diet-induced obesity (DIO) on: (i) vivo transit; (ii) myenteric plexus by recording responses nicotine 2-methyl-5-hydroxytryptamine (2-methyl-5-HT), together with expression tryptophan hydroxylase (TPH) 1 2, serotonin reuptake transporter, choline...
Bifidobacteria are among the first colonisers of gastrointestinal tract breast-fed newborns due to, other things, their ability to metabolise oligosaccharides naturally occurring in human milk. The presence bifidobacteria infant gut has been shown promote intestinal health and homeostasis as well preserve a functional barrier, thus positively influencing host well-being. Among human-associated commensals, Bifidobacterium bifidum described only species capable extracellular degradation both...
LPS-induced endotoxemia is associated with gut immune stimulation, mucosal inflammation, colonic paracellular permeability (CPP) alteration, and it promotes bacterial translocation (BT). Gut increase linked to LPS barrier dysfunction resulting BT. However, the mechanisms involved in these alterations remain unknown. We aimed evaluate role of mast cells luminal serine protease activity (PA) CPP BT induced by LPS. Rats receiving doxantrazole, a cell stabilizer, combined or not from Escherichia...
Suboptimal activation of T lymphocytes by melanoma cells is often due to the defective expression class I major histocompatibility antigens (MHC-I) and costimulatory molecules. We have previously shown that geranylgeranyl transferase inhibition (done with GGTI-298) stimulates anti-melanoma immune response through MHC-I molecule in B16F10 murine model [1].In this study, it vaccination mIFN-gand GGTI-298 pretreated induces a protection against untreated tumor growth pulmonary metastases...
Since the viability throughout human gastro-intestinal (GI) tract is a key metric to select new probiotics, we aimed develop an evolutive and robust semi-dynamic model, named Gastro-Intestinal Digestive Simulator (GIDS), mimicking pH variations of upper GI based on latest Infogest in vitro digestion protocol recommendations. We first tested GIDS its reproducibility by measuring, during digestion, cultivability bacterial strain contained two marketed fermented milk products. Then, used this...
Abstract Introduction Obesity has become a pandaemic even in children. We aimed to investigate the impact of obesity youth on later pancreatic intrinsic nervous system (PINS) phenotype and control insulin secretion. Methods Young mice (5‐week‐old, T0 group) were fed either normal diet (ND or Western (WD for 12 weeks. Pancreas density, PINS pancreas anatomy analysed by immunohistochemistry at adulthood WD groups). Insulin secretion was also studied these 3 groups using new model ex vivo...