A5009442519- Cutaneous lymphoproliferative disorders research
- T-cell and Retrovirus Studies
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Virus-based gene therapy research
- Mast cells and histamine
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Gut microbiota and health
- Biotin and Related Studies
- Eosinophilic Disorders and Syndromes
- Adolescent and Pediatric Healthcare
- Probiotics and Fermented Foods
- Adenosine and Purinergic Signaling
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Diabetes and associated disorders
- Tryptophan and brain disorders
- Psoriasis: Treatment and Pathogenesis
- Diabetes Treatment and Management
University of Copenhagen
2014-2020
LEO Foundation
2019-2020
Bipar
2014
Zero to Three
2014
Short chain fatty acids (SCFAs), such as acetate, butyrate and propionate, are products of microbial macronutrients fermentation that distribute systemically believed to modulate host immune responses. Recent data have indicated certain SCFAs, directly human dendritic cell (DC) function. Given the role DCs in initiating shaping adaptive response, we now explore how SCFAs affect activation antigen-specific CD8+ T cells stimulated with autologous, MART1 peptide-pulsed DC. We show reduces...
// Nina A. Sibbesen 1 , Katharina L. Kopp Ivan V. Litvinov 2 Lars Jønson 3 Andreas Willerslev-Olsen Simon Fredholm David Petersen Claudia Nastasi Thorbjørn Krejsgaard Lise M. Lindahl 4 Robert Gniadecki 5 Nigel P. Mongan 6 Denis Sasseville Mariusz Wasik 7 Iversen Charlotte Bonefeld Carsten Geisler Anders Woetmann and Niels Odum Department of Immunology Microbiology, University Copenhagen, Denmark Division Dermatology, McGill Health Centre, Montréal, Quebec, Canada...
Deregulation of STAT signaling has been implicated in the pathogenesis for a variety cancers, including CTCL. Recent reports indicate that loss STAT4 expression is an important prognostic marker CTCL progression and associated with acquisition T helper 2 cell phenotype by malignant cells. However, little known about molecular mechanism behind downregulation this cancer. In current work we test STAT6 via RT-PCR and/or Western Blot lesional skin samples immortalized patient-derived lines....
// Lise M. Lindahl 1 , Simon Fredholm 2 Claudine Joseph Boye Schnack Nielsen 3 Lars Jønson 4 Andreas Willerslev-Olsen Maria Gluud Edda Blümel David L. Petersen Nina Sibbesen Tengpeng Hu Claudia Nastasi Thorbjørn Krejsgaard Ditte Jæhger Jenny Persson 5 Nigel Mongan 6 Mariusz A. Wasik 7 Ivan V. Litvinov 8 Denis Sasseville 9 Sergei B. Koralov 10 Charlotte Bonefeld Carsten Geisler Anders Woetmann Elisabeth Ralfkiaer 11 Iversen Niels Odum Department of Dermatology, Aarhus...
Sustained inflammation is a key feature of mycosis fungoides (MF), the most common form cutaneous T-cell lymphoma (CTCL). Resident IL9-producing T cells have been found in skin infections and certain inflammatory diseases, but their role MF currently unknown.We analyzed lesional from patients with for expression IL9 its regulators. To determine which were producing IL9, high-throughput sequencing was used to identify malignant clones Vb-specific antibodies employed visualize histologic...
Staphylococcus aureus is implicated in disease progression cutaneous T-cell lymphoma (CTCL). Here, we demonstrate that malignant T cell lines derived from CTCL patients as well primary CD4+ cells Sézary syndrome are considerably more resistant to alpha-toxin-induced death than their non-malignant counterparts. Thus, a subset of the ratio between and increases significantly following exposure alpha-toxin. Whereas toxin-induced ADAM10 dependent healthy cells, resistance alpha-toxin involves...
Staphylococcus aureus and its toxins have been linked to disease progression mortality in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8+ T cells play a crucial role anti-cancer responses high cell numbers tumor lesions are associated with favorable prognosis CTCL. Here, we show that from both healthy donors Sézary syndrome patients highly susceptible death induced by Staphylococcal alpha-toxin, whereas malignant not. Importantly, alpha-toxin almost completely blocks cytotoxic...
Skin lesions from mycosis fungoides (MF) patients display an increased expression of interleukin-15 (IL-15), IL-17F, and other cytokines implicated in inflammation malignant cell proliferation cutaneous T-cell lymphoma (CTCL). In the leukemic variant CTCL, Sézary syndrome (SS), IL-2 IL-15 trigger activation Jak-3/STAT3 pathway transcription IL17A gene, whereas it is unknown what causes expression, Jak3/STAT3 activation, production IL-17F MF. Here, we studied regulation its relation to MF...
B-lymphoid tyrosine kinase (BLK) is a non-receptor belonging to the SRC family kinases. BLK known be functionally involved in B-cell receptor signaling and development. New evidence suggests that ectopically expressed putative oncogene cutaneous T-cell lymphoma other malignancies. However, little about role of lymphomagenesis, oncogenic function seems depend on cellular context. Importantly, also hematological multiple non-hematological malignancies including breast, kidney, lung cancers,...
Adenosine triphosphate (ATP) is known to induce cell death in T lymphocytes at high extracellular concentrations. CD4+ and CD8+ have a differential response ATP, which mice due differences the P2X7 receptor expression levels. In contrast, we observed that difference human lymphocyte towards synthetic ATP-analogue BzATP not explained by expression. Rather, BzATP-induced naïve immune-activated subtypes correlated with of another ATP-binding receptor: P2Y11 receptor. recombinant system,...
Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL), is a lymphoproliferative disorder characterized by proliferation malignant T cells in chronic inflammatory environment skin. The nature MF still not fully understood, but aberrant microRNA (miR) expression and function seem to play an important role pathogenesis disease progression have been proposed as putative marker. Recent studies reported miR-93 situin lesions linked dysregulated advanced stages MF....
The thioredoxin-interacting protein (TXNIP) is involved in cellular metabolism and cell proliferation, recently, deficient expression of TXNIP has been associated with progression poor outcome for cancer patients.To assess function malignant T cells from cutaneous T-cell lymphoma (CTCL).CTCL-derived (MyLa2059, PB2B) non-malignant (MyLa1850) lines were analysed by Western blotting qPCR expression. Subsequently, the CTCL treated GSK126 - an inhibitor enhancer zeste homolog 2 (EZH2)...
Abstract Background Treatment with antipsychotics is associated an increased risk of type 2 diabetes mellitus (T2D), and levels inflammatory biomarkers are present in patients T2D. We previously demonstrated that the glucagon-like peptide-1 receptor agonist liraglutide significantly reduced glucometabolic disturbances body weight prediabetic, overweight/obese schizophrenia-spectrum disorder treated clozapine or olanzapine. This study aims to assess involvement cytokines therapeutic effects...
The voltage-gated potassium channel Kv1.3 (KCNA3) is expressed by a subset of chronically activated memory T cells and plays an important role in their activation proliferation. Here, we show that primary malignant isolated from patients with Sézary syndrome (SS) express are sensitive to potent inhibitors ShK Vm24, but not less inhibitor [N17A/F32T]-AnTx. blockade inhibits CD3/CD28-induced proliferation IL-9 expression SS concentration-dependent manner. In parallel, CD3/CD28-mediated CD25...