A5065167506- Analytical Chemistry and Chromatography
- Advanced Chemical Sensor Technologies
- Fatty Acid Research and Health
- Metabolomics and Mass Spectrometry Studies
- Ruminant Nutrition and Digestive Physiology
- Mass Spectrometry Techniques and Applications
- Biochemical and Molecular Research
- Lipid metabolism and biosynthesis
- Fungal Biology and Applications
- Antibiotic Resistance in Bacteria
- Natural product bioactivities and synthesis
- Meat and Animal Product Quality
- Tuberculosis Research and Epidemiology
- Enzyme Structure and Function
- Sunflower and Safflower Cultivation
- Natural Products and Biological Research
- Phytochemistry and Biological Activities
- Genetic and phenotypic traits in livestock
- Granular flow and fluidized beds
- Polymer Foaming and Composites
- ATP Synthase and ATPases Research
- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Phytochemicals and Antioxidant Activities
- Rheology and Fluid Dynamics Studies
Comenius University Bratislava
2015-2024
University Library in Bratislava
2024
Institute of Chemistry of the Slovak Academy of Sciences
2007-2020
Global Fund to Fight AIDS, Tuberculosis and Malaria
2015
To combat the emergence of drug-resistant strains Mycobacterium tuberculosis, new antitubercular agents and novel drug targets are needed. Phenotypic screening a library 594 hit compounds uncovered two leads that were active against M. tuberculosis in its replicating, non-replicating, intracellular states: 7947882 (5-methyl-N-(4-nitrophenyl)thiophene-2-carboxamide) 7904688 (3-phenyl-N-[(4-piperidin-1-ylphenyl)carbamothioyl]propanamide). Mutants resistant to both harbored mutations ethA...
Chronic obstructive pulmonary disease (COPD) is a major cause of death worldwide. Acute exacerbations COPD (AECOPD), caused by infectious and non-infectious agents, contribute to an increase in mortality. The diagnostic procedure AECOPD mainly based on clinical features. aim this pilot study was identify whether volatile organic compounds (VOCs) breath could be used discriminate for acute exacerbated COPD. Three patient groups were included controlled study: patients (n = 14, age mean ± SD:...
Thymol affects various types of tumor cell lines, including colorectal cancer cells. However, the hydrophobic properties thymol prevent its wider use. Therefore, new derivatives (acetic acid ester, β-D-glucoside) have been synthesized with respect to hydrophilic properties. The cytotoxic effect on lines HT-29 and HCT-116 was assessed via MTT assay. genotoxic determined by comet assay micronucleus analysis. ROS production evaluated using ROS-Glo™ H2O2 Assay. We confirmed that one ester) has...
ABSTRACT Mycobacterium tuberculosis possesses a thick and highly hydrophobic cell wall principally composed of mycolyl-arabinogalactan-peptidoglycan complex, which is critical for survival virulence. DprE1 well-characterized component decaprenyl-phospho-ribose epimerase, produces decaprenyl-phospho-arabinose (DPA) the biosynthesis mycobacterial arabinans. Upstream dprE1 lies rv3789 , encodes short transmembrane protein GtrA family, whose members are often involved in synthesis surface...
This paper investigates the Angle of Repose (AoR) powder materials with respect to their morphological and rheological properties. Glass beads, sand, flour semolina different particle sizes were used as experimental materials. The investigated material was analysed shape size. properties obtained by a shear cell test. AoR in terms cohesion, bulk density, size circularity. More cohesive such samples exhibited largest > 40°, indicating poor flowability. bead high circularity value had...
Abstract A GC/MS procedure has been developed, optimized, and applied to characterization of oil binders in paintings. The involves hydrolysis lipids fatty acids (FAs) derivatization FAs acid methyl esters (FAMEs) by a solution sodium methanolate methanol at an elevated temperature. FAMEs are analyzed temperature‐programed GC followed full‐scan MS. Old dried samples subjected extraction nonpolymerized into dichloromethane prior hydrolysis. method provides good repeatability results the...
The aim of this paper was to describe the influence high-shear wet granulation process parameters on tablet tensile strength and compaction behavior a powder mixture granules containing hydralazine. hydralazine eight types were compacted into tablets evaluated using Heckel, Kawakita Adams analyses. created two liquid (distilled water aqueous solution polyvinylpyrrolidone), at different impeller speeds (500 700 rpm) with massing times (without for 2 min). Granulation resulted in improved...
Abstract A simple method for the simultaneous derivatization of carbohydrates, polyols, amines and amino acids using hexamethyldisilazane N , O ‐bis(trimethylsilyl)trifluoroacetamide was developed. This allows direct urine samples without sample pretreatment before derivatization. The successfully used analysis selected metabolites in healthy individuals neonates suffering from galactosemia. limits detection by positive chemical ionization gas chromatography with tandem mass spectrometry...
This work deals with the creation of a mathematical model which will predict sufficient accuracy size granules in high-shear granulation process. The aim paper was to create created dimensionless criteria give as function selected process parameters, equipment, and experimental material. Microcrystalline cellulose were manufactured an granulator our own construction using high amount liquid (absolute humidity >40%). also focuses on study granule distribution yield achieving target fraction...
The quality of 40 carcasses light lambs the synthetic population Slovak Dairy sheep from (a) artificial rearing (AR) and (b) traditional (TR) was assessed on basis fatty acids profile intramuscular fat (IMF). Lambs AR in comparison with TR were lower as (FAs) profile. content conjugated linolic acid (CLA) severalfold higher (0.749 vs. 0.193 g.100g-1 FAME, P<0.001) than lambs. Similarly, trans-vaccenic (TVA), á-linolenic (ALA), rumenic (RA), eicosapentaenoic (EPA) docosahexaenoic (DHA)...