A5063351458- Respiratory Support and Mechanisms
- Fungal Biology and Applications
- Mechanical Circulatory Support Devices
- Mycorrhizal Fungi and Plant Interactions
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Plant Reproductive Biology
- Plant Pathogens and Fungal Diseases
- Neonatal Respiratory Health Research
- Nitric Oxide and Endothelin Effects
- Transplantation: Methods and Outcomes
- Sepsis Diagnosis and Treatment
- Yeasts and Rust Fungi Studies
- Renal Diseases and Glomerulopathies
- Long-Term Effects of COVID-19
- Traumatic Brain Injury and Neurovascular Disturbances
- Eicosanoids and Hypertension Pharmacology
- Plant Molecular Biology Research
- Fungal and yeast genetics research
- Plant and fungal interactions
- Curcumin's Biomedical Applications
- Plant-Microbe Interactions and Immunity
- RNA Interference and Gene Delivery
- Photosynthetic Processes and Mechanisms
Medical University of Vienna
2016-2025
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
1993-2025
University of Oxford
2021
Universitätszahnklinik Wien
2020
Pain and Rehabilitation Medicine
2018
Charité - Universitätsmedizin Berlin
2005-2015
University Medical Center of the Johannes Gutenberg University Mainz
2015
Johannes Gutenberg University Mainz
2015
Intensive Care Society
2011
University of Vienna
1998-2008
Objectives: The first tissue engineered decellularized porcine heart valve, Synergraft® (Cryolife Inc., USA) was introduced in Europe as an alternative to conventional biological valves. This is the report of rapid failure these new grafts a small series. Materials and methods: In 2001, 2 model 500 700 valves were implanted four male children (age 2.5–11 years) right ventricular outflow tract root. Two patients had Ross operation two homograft replacement. Results: cryopreserved appeared...
Background To investigate the role of endothelial nitric oxide synthase (NOS3) in left ventricular (LV) remodeling after myocardial infarction (MI), impact anterior descending coronary artery ligation on LV size and function was compared 2- to 4-month-old wild-type (WT) NOS3-deficient mice (NOS3 −/− ). Methods Results Two days MI, both strains had a similar size, fractional shortening, ejection fraction by echocardiography. Twenty-eight dilated LVs with decreased shortening lower fractions....
Phosphodiesterase type 5 (PDE5) hydrolyzes cyclic guanosine monophosphate in the lung, thereby modulating nitric oxide (NO)/cyclic monophosphate-mediated pulmonary vasodilation. Inhibitors of PDE5 have been proposed for treatment hypertension. In this study, we examined and systemic vasodilator properties sildenafil, a novel selective inhibitor, which has approved erectile dysfunction.In an awake lamb model acute hypertension induced by intravenous infusion thromboxane analog U46619,...
Abstract Introduction Acute respiratory failure (ARF) is the main reason for intensive care unit (ICU) admissions in patients with hematologic malignancies (HMs). We report first series of adult ARF and HMs treated extracorporeal membrane oxygenation (ECMO). Methods This a retrospective cohort study 14 (aggressive non-Hodgkin lymphoma (NHL) n = 5; highly aggressive NHL, that acute lymphoblastic leukemia or Burkitt lymphoma, Hodgkin 2; myeloid leukemia, 1; multiple myeloma, 1) receiving ECMO...
Data show that carbon monoxide (CO) exerts direct antiinflammatory effects in vitro and vivo after LPS challenge a mouse model. We hypothesized CO may act as an agent human endotoxemia. The aim of this trial was to study the inhalation on cytokine production during experimental main randomized, double-blinded, placebo-controlled, two-way cross-over healthy volunteers. Each volunteer inhaled synthetic air (as placebo) 500 ppm for 1 hour random order with washout period 6 weeks received...
Reactive oxygen species (ROS) have been implicated in the production of glomerular damage passive Heymann nephritis (PHN), an experimental form membranous nephropathy with neutrophil-independent proteinuria. Immunohistochemistry monoclonal antibodies specific for cytochrome b558 (a major component oxidoreductase complex respiratory burst stimulated neutrophilic granulocytes) showed that this enzyme is localized within visceral epithelial cells (GECs) a dense, granular pattern rats PHN and By...
Background —Sepsis can be complicated by severe myocardial dysfunction and is associated with increased nitric oxide (NO) production inducible NO synthase (NOS2). To investigate the role of NOS2 in endotoxin-induced vivo, we studied wild-type NOS2-deficient mice. Methods Results —Serial echocardiographic parameters function were measured before at 4, 7, 16, 24 hours after an endotoxin challenge. Seven challenge either or saline, systemic left ventricular pressures measured, first derivative...
Abstract Background Duration of invasive mechanical ventilation (IMV) prior to extracorporeal membrane oxygenation (ECMO) affects outcome in acute respiratory distress syndrome (ARDS). In coronavirus disease 2019 (COVID-19) related ARDS, the role pre-ECMO IMV duration is unclear. This single-centre, retrospective study included critically ill adults treated with ECMO due severe COVID-19-related ARDS between 01/2020 and 05/2021. The primary objective was determine whether cannulation...
In patients with acute respiratory distress syndrome (ARDS), permissive hypercapnia is a strategy to decrease airway pressures prevent ventilator-induced lung damage by lowering tidal volumes and tolerating higher arterial carbon dioxide tension. However, in experimental studies impairs myocardial contractility hemodynamic function. We investigated the effect of short-term on hemodynamics ARDS. hypothesized that administration tromethamine (THAM), buffer which does not increase production,...
The A alpha mating locus is one of four multiallelic loci that govern sexual development in the basidiomycete fungus Schizophyllum commune. We have determined nucleotide sequence encoding three types, 1, 3, and 4. found for 3 4 consists two genes: Y Z. 1 encodes only gene, Y. Z polypeptides encoded by different alleles exhibit 42% identity. 49-54% finding deduced homeodomain motifs suggests these may be DNA-binding regulatory proteins control expression developmental genes. polypeptide also...
Background Recent years have seen the introduction of innovative additive therapies for acute respiratory distress syndrome. However, because there are no reliable predictors response to a particular therapy, potential responders specific therapeutic intervention may be lost. Therefore, authors evaluated effect combined approach on survival patients with syndrome, when treated according strict algorithm. Methods During 2.5-yr period, 84 syndrome were assigned standardized treatment protocol....
Mating experiments were conducted to determine the existence of biological species (intersterility groups) root-rotting fungus, Heterobasidion annosum (Basidiomycotina, Homobasidiomycetes) in North America. Initial screening utilized tester strains from Finland and identified representatives both “S” “P” intersterility groups. Pairings American group with strains, however, revealed a significant degree interfertility between two The data indicate that is under regulation simple, Mendelian...
In Brief BACKGROUND: Intermittent hypoxia may occur in a number of clinical scenarios, including interruption myocardial blood flow or breathing disorders such as obstructive sleep apnea. Although intermittent has been linked to cardiovascular and cerebrovascular disease, the effect on human heart is not fully understood. Therefore, present study, we compared cellular responses cultured adult cardiac myocytes (HACMs) exposed different conditions continuous normoxia. METHODS: HACMs were...
SARS-CoV-2 gains cell entry via angiotensin-converting enzyme (ACE) 2, a membrane-bound of the "alternative" (alt) renin-angiotensin system (RAS). ACE2 counteracts angiotensin II by converting it to potentially protective 1-7. Using mass spectrometry, we assessed key metabolites classical RAS (angiotensins I-II) and alt-RAS 1-7 1-5) pathways as well ACE concentrations in 159 patients hospitalized with COVID-19, stratified disease severity (severe, n = 76; non-severe: 83). Plasma renin...
Heymann nephritis is an experimental autoimmune disease in rats that characterized by accumulation of immune deposits (IDs) kidney glomeruli. The initiated the binding circulating antibodies to a membrane glycoprotein, gp330, which resident protein clathrin-coated pits on glomerular epithelial cells (podocytes). We have defined domain representing about 10% gp330 appears be responsible for formation stable IDs. A cDNA clone (clone 14) was isolated from rat expression library screening with...
ABSTRACTPrevious studies of Heterobasidion annosum have shown the existence two intersterility groups (biological species) designated “S” and “P.” Nearly complete exists between Finnish representatives groups; however, a significant degree interfertility North American “P” groups. Analyses progeny from laboratory crosses identified five genes that specify intersterile interfertile mating reactions. Segregation alleles was observed for four genes, linkage analysis performed, model interaction...
Recently, 3 clinical trials revealed encouraging results in recanalization and outcome acute stroke patients when 2-MHz transcranial Doppler monitoring was applied. This study investigated whether a 1.8-MHz commercial diagnostic ultrasound device has the potential to facilitate thrombolysis using an vitro model.Duplex-Doppler, continuous wave-Doppler, pulsed wave (PW)-Doppler were compared on their impact recombinant tissue plasminogen activator (rtPA)-mediated thrombolysis. Blood clots...