A5083638276- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Platelet Disorders and Treatments
- Sepsis Diagnosis and Treatment
- Acute Myocardial Infarction Research
- COVID-19 Clinical Research Studies
- Thermal Regulation in Medicine
- Ultrasound in Clinical Applications
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Blood disorders and treatments
- Respiratory Support and Mechanisms
- Immune Response and Inflammation
- Heart Failure Treatment and Management
- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Mechanical Circulatory Support Devices
- Inflammatory Biomarkers in Disease Prognosis
- Chemokine receptors and signaling
Wilhelminen Hospital
2020-2023
Wiener Krankenanstaltenverbund
2020-2023
Medical University of Vienna
2013-2022
Universitätszahnklinik Wien
2019
Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin
2019
Klinik Niederrhein
2019
Evangelisches Klinikum Niederrhei
2019
Universität Hamburg
2017
University Medical Center Hamburg-Eppendorf
2017
University Surgical Associates
2015
Many animals are used in research on blood coagulation and fibrinolysis, but the relevance of animal models to human health is often questioned because differences between species. The objective was find an appropriate species, which mimics profile humans most adequately. Species with without thrombin stimulation vitro were assessed whole by Rotation Thromboelastometry (ROTEM). Endogenous generation measured platelet-poor plasma. Measurements performed from five different species: humans,...
Data show that carbon monoxide (CO) exerts direct antiinflammatory effects in vitro and vivo after LPS challenge a mouse model. We hypothesized CO may act as an agent human endotoxemia. The aim of this trial was to study the inhalation on cytokine production during experimental main randomized, double-blinded, placebo-controlled, two-way cross-over healthy volunteers. Each volunteer inhaled synthetic air (as placebo) 500 ppm for 1 hour random order with washout period 6 weeks received...
Macrophages play a key role in responding to pathogens and initiate an inflammatory response combat microbe multiplication. Deactivation of macrophages facilitates resolution the response. Deactivated are characterized by immunosuppressive phenotype, but lack unique markers that can reliably identify these cells explains poorly defined biological this macrophage subset. We identified lipocalin 2 (LCN2) as both marker deactivated deactivator. show LCN2 attenuated early impaired bacterial...
Ibutilide is a rapid-acting antiarrhythmic drug with worldwide use for conversion of recent-onset atrial fibrillation. Vernakalant, approved in the EU 2010, likewise used intravenously, proven efficacy and safety compared placebo amiodarone randomized clinical trials. The aim our study was to compare time rate within 90 min patients fibrillation treated vernakalant or ibutilide. A controlled trial registered at clinicaltrials.gov (NCT01447862) performed 100 emergency department tertiary care...
Troponin is a crucial biomarker in the emergency department (ED). Current evidence does not support differentiation between an uncomplicated tachyarrhythmia and significant coronary artery disease (CAD). The aim of present study was to assess use troponins predict CAD mortality patients with acute atrial fibrillation/flutter (AF/AFL). This cohort included 3,425 consecutive episodes AF/AFL treated at ED Medical University Vienna 2012 2024. Coronary angiography performed 251 cases. Patients...
Objective: The Duffy receptor is a promiscuous for chemokines and selectively binds CXC CC with high affinity. Preclinical data show that presence of the on red blood cells may influence plasma levels proinflammatory cytokines be protective during inflammation. This trial was designed to investigate antigen human inflammation in vivo. Design: Prospective, analyst-blinded clinical trial. Patients: A total 32 healthy male volunteers: 16 Duffy-positive white subjects Duffy-negative African...
ARC1779 is an aptamer, which blocks binding of the von Willebrand Factor (VWF) A1 domain to platelet GPIb receptors. VWF increased in elderly setting acute myocardial infarction (AMI), as reflected by shear-dependent function. We hypothesized that concentration-dependently inhibits ex vivo function, and this concentration effect relationship may be shifted patients with AMI. studied dose response curves for on activity, agonist-induced aggregation. included AMI standard treatment (n = 40),...
Granulocyte colony-stimulating factor (G-CSF) stimulates the bone marrow to produce granulocytes and stem cells is widely used accelerate neutrophil recovery after chemotherapy. Interestingly, specific G-CSF receptors have been demonstrated not only on myeloid cells, but also platelets. Data effects of platelet function are limited partly conflicting. The objective this study was determine effect aggregation in vivo activation. Seventy-eight, healthy volunteers were enrolled into randomised,...
Summary Plasma levels of von Willebrand factor (VWF) are increased in patients with cardiovascular risk factors. Various studies aimed to elucidate the relation VWF thrombo - embolic events, ischaemic stroke as well peripheral arterial occlusive disease. In general population, there is only a weak association between and future events or stroke. contrast, predictive documented vascular Those suffer higher incidence major adverse cardiac including death. The extent release its independently...
Background Several studies have shown that statins beneficial effects in COPD regarding lung function decline, rates and severity of exacerbation, hospitalisation need for mechanical ventilation. Methods We performed a randomised double-blind placebo-controlled single-centre trial simvastatin at daily dose 40 mg versus placebo patients with Global Initiative Chronic Obstructive Lung Disease criteria grades 2–4 tertiary care pulmonology department Austria. Scheduled treatment duration was 12...
Organ failure increases mortality in patients with liver cirrhosis. Data about resuscitated cardiac arrest cirrhosis are missing. This study aims to assess aetiology, survival and functional outcome after successful cardiopulmonary resuscitation (CPR) without cirrhosis.Analysis of prospectively collected registry data consecutively hospital-admitted following CPR was performed. Patient's characteristics, admission diagnosis, severity disease, course short- long-term as well were assessed...