A5000290428- Mast cells and histamine
- Polyamine Metabolism and Applications
- Antimicrobial Resistance in Staphylococcus
- Amino Acid Enzymes and Metabolism
- COVID-19 Clinical Research Studies
- Renin-Angiotensin System Studies
- Infective Endocarditis Diagnosis and Management
- Antibiotic Use and Resistance
- Pharmacological Effects and Assays
- Streptococcal Infections and Treatments
- Nosocomial Infections in ICU
- Nanofabrication and Lithography Techniques
- Diabetes and associated disorders
- Extracellular vesicles in disease
- Photoacoustic and Ultrasonic Imaging
- Clostridium difficile and Clostridium perfringens research
- Bacterial Identification and Susceptibility Testing
- Adenosine and Purinergic Signaling
- Receptor Mechanisms and Signaling
- Calcium signaling and nucleotide metabolism
- Ion channel regulation and function
- Nonlinear Optical Materials Studies
- SARS-CoV-2 and COVID-19 Research
Medical University of Vienna
2022-2025
D’Or Institute for Research and Education
2023
Abstract Objective and design SARS-CoV-2 vaccines are recommended for mastocytosis patients. We describe clinical symptoms, chemokine, cytokine, metabolomic lipidomic derangements in a systemic patient following mRNA-1273 booster vaccination. Methods Twenty-eight chemokines cytokines, 41 amino acids 16 lipid classes were quantified with state-of-the-art methods. Results Mast cell activation (MCA) symptoms started 24 h after the vaccination significant metabolic, cytokine derangements....
Peritonitis remains the major infectious complication in setting of peritoneal dialysis (PD). Despite known only moderate pathogenicity, most frequently detected pathogens PD-related peritonitis are surprisingly coagulase-negative staphylococci. However, this could be explained, at least part, by Staphylococcus aureus small colony variants (SCVs) induced PD fluids (PDFs) and misidentified routinely used microbiological methods. Bacteria were exposed to commonly PDFs various regimens designed...
Abstract Background Device-related bacterial infections account for a large proportion of hospital-acquired infections. The ability bacteria to form biofilm as protective shield usually makes treatment impossible without removal the implant. Topographic surfaces have attracted considerable attention in studies seeking antibacterial properties need additional antimicrobial substances. As there are still no valid rules design microstructured surfaces, fast, reproducible production technique...
Abstract Purpose As they are effective and well tolerated, aminopenicillins still the cornerstone for treatment of enterococcal infections. Current guidelines infective endocarditis (IE) recommend combination treatments, which carry a higher risk adverse effects based on limited in vitro experimental data. The aim this study was therefore to evaluate treatments IE real-life practice. Methods A total 4121 episodes bloodstream infections, occurring between 1994 2019, were screened evidence IE....
Secondary infections in coronavirus disease 2019 (COVID-19) patients are difficult to distinguish from inflammation associated with COVID-19 and/or extracorporeal membrane oxygenation (ECMO). Therefore, highly specific and sensitive biomarkers needed identify whom antimicrobial therapy can be safely withheld. In this prospective monocentric study, 66 admitted the intensive care unit (ICU) for ECMO evaluation were included. A total of 46 (70%) secondary identified by using broad...
Incubation of reduced nicotinamide adenine dinucleotide (NADH) but not oxidized NAD+ with ortho-aminobenzaldehyde (oABA) generated an uncharacterized chromophore absorption peak characteristic a dihydroquinazoline condensate. This is responsible for non-specific signal in diamine oxidase (DAO) activity assay based on the generation fluorescent structures directly from DAO substrates. Herein we show that at pH values below 3.0 glycosidic bond NADH/NADPH broken releasing double protonated...
To test whether recombinant human diamine oxidase (rhDAO) with a mutated heparin-binding motif (mHBM), which shows an increased alpha-distribution half-life, prevents histamine-induced hemodynamic effects.Thirty-eight female guinea pigs were either pretreated rhDOA_mHBM or buffer.Guinea received continuous infusion of histamine. Heart rate (HR), body core temperature and mean arterial pressure (MAP) measured blood was collected.Continuous intravenous 8 µg/kg/min histamine peak plasma levels...
Background: Venous thromboembolism (VTE) is a frequent complication of COVID-19.The identification VTE risk factors (RF) may help physicians to select the best anticoagulation schedule in clinical practice.Aims: To evaluate RF associated with hospitalized COVID-19 patients.Methods: We retrospectively analyzed (Jan/20-Feb/21) all cases submitted compression ultrasound (CUS) and/or CT pulmonary angiogram (CTPA) investigate deep venous thrombosis (DVT) or embolism (PE), respectively, based on...