A5084254623- SARS-CoV-2 and COVID-19 Research
- Financial Literacy, Pension, Retirement Analysis
- Retirement, Disability, and Employment
- Antimicrobial Resistance in Staphylococcus
- Immunotherapy and Immune Responses
- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Viral Infections and Immunology Research
- Plant Pathogenic Bacteria Studies
- Antimicrobial Peptides and Activities
- Antibiotic Resistance in Bacteria
- COVID-19 Clinical Research Studies
- Bacteriophages and microbial interactions
- Health and Conflict Studies
- Rheumatoid Arthritis Research and Therapies
- Chemokine receptors and signaling
- Colorectal and Anal Carcinomas
- Risk Perception and Management
- Bacillus and Francisella bacterial research
- Public Relations and Crisis Communication
- Disaster Management and Resilience
- Long-Term Effects of COVID-19
- Medical Research and Practices
- Sphingolipid Metabolism and Signaling
- Glycosylation and Glycoproteins Research
Medical University of Vienna
2011-2024
Bayer (Germany)
2024
Paracelsus Medizinische Privatuniversität
2021-2022
Nuremberg Hospital
2021
University Hospital Ulm
2021
Center for Rheumatology
2017
Mologen (Germany)
2016
Tanabe Research Laboratories
2007
University of Massachusetts Boston
2006
Essen University Hospital
2005
<i>Background:</i> Increasing attention has been given to the transparency of potential conflicts interest in clinical medicine and biomedical sciences, particularly journal publishing science advisory panels. The authors examined degree type financial ties pharmaceutical industry panel members responsible for revisions <i>Diagnostic Statistical Manual Mental Disorders</i><i>(DSM)</i>. <i>Methods:</i> By using multimodal screening techniques...
Abstract Background and purpose Rituximab (RTX) is frequently used off‐label in multiple sclerosis. However, studies on the risk–benefit profile of RTX pediatric‐onset sclerosis are scarce. Methods In this multicenter retrospective cohort study, patients with from Sweden, Austria Germany, who received treatment were identified by chart review. Annualized relapse rates, Expanded Disability Status Scale scores magnetic resonance imaging parameters (new T2 lesions contrast‐enhancing lesions)...
Objective The study was undertaken to assess the impact of B cell depletion on humoral and cellular immune responses severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) vaccination in patients with various neuroimmunologic disorders anti‐CD20 therapy. This included an analysis T vaccine response SARS‐CoV‐2 Delta variant. Methods We investigated prospectively mRNA 82 therapy age‐ sex‐matched healthy controls. For quantification antibodies, Elecsys anti‐SARS‐CoV‐2 viral spike (S)...
Background: The interleukin-1-receptor antagonist IL1RA (encoded by the IL1RN gene) is a potent competitive to interleukin-1 (IL1) and thereby mainly involved in regulation of inflammation. Previous data indicated role muscle-invasive urothelial carcinoma bladder (UCB) as well an IL1-dependent decrease tissue barrier function, potentially contributing cancer cell invasion. Objective: Based on these observations, here we investigated potential roles IL1RA, IL1A, IL1B invasion vitro. Methods:...
The increasing prevalence of methicillin-resistant Staphylococcus aureus (MRSA) strains resistant to non-beta-lactam antimicrobials poses a significant challenge in treating severe MRSA bloodstream infections. This study explores resistance development and mechanisms isolates, especially after the first dalbavancin-resistant strain our hospital 2016. investigated 55 isolates (02/2015–02/2021) from University Hospital Medical Vienna, Austria. MICs dalbavancin, linezolid, daptomycin were...
Patients with inborn errors of immunity (IEI) are at increased risk for severe courses SARS-CoV-2 infection. COVID-19 vaccination provides effective protection in healthy individuals. However, it remains unclear whether is efficient and safe patients constitutional dysfunctions the immune system. Thus, we analyzed humoral response, adverse reactions assessed disease activity underlying after a cohort suffering from IEIs or mannan-binding lectin deficiency (MBLdef).Vaccination response was...
Peritonitis remains the major infectious complication in setting of peritoneal dialysis (PD). Despite known only moderate pathogenicity, most frequently detected pathogens PD-related peritonitis are surprisingly coagulase-negative staphylococci. However, this could be explained, at least part, by Staphylococcus aureus small colony variants (SCVs) induced PD fluids (PDFs) and misidentified routinely used microbiological methods. Bacteria were exposed to commonly PDFs various regimens designed...
Objectives This study aimed to assess the duration of humoral responses after two doses SARS-CoV-2 mRNA vaccines in patients with inflammatory joint diseases and IBD booster vaccination compared healthy controls. It also analyze factors influencing quantity quality immune response. Methods We enrolled 41 rheumatoid arthritis (RA), 35 seronegative spondyloarthritis (SpA), suffering from bowel disease (IBD), excluding those receiving B-cell-depleting therapies. assessed total anti-SARS-CoV-2...
Abstract Introduction DNA‐based TLR9 agonists are potent activators of the immune system. ProMune® and dSLIM® belong to different families both have been established as cancer immunotherapeutics in clinical proof‐of‐concept studies. Unfortunately, failed pivotal oncological trials. dSLIM®, active ingredient Lefitolimod (MGN1703), successfully finished a double‐blinded, placebo‐controlled phase II study patients with advanced colorectal cancer, exhibiting improved progression‐free survival...
Here we analyzed SARS-CoV-2-specific antibodies and T-cell responses after two coronavirus disease 2019 vaccinations over a six-month period in patients with hematological malignancies assessed the effect of third vaccination subgroup. Sixty-six 66 healthy controls were included. After seroconversion was seen 52% T-cell-specific response 59% compared 100% (p = 0.001). Risk factors for poor serological age (<65a), history anti-CD20 therapy within year preceding vaccination, CD19+ B-cells <...
Objectives: This study investigated the synergistic in vitro and vivo activity of cefazolin plus fosfomycin against methicillin-susceptible methicillin-resistant S. aureus (MSSA MRSA) to provide basis for a potential treatment alternative. Methods: Antimicrobial susceptibility synergy tests were performed with five MSSA MRSA isolates using broth microdilution chequerboard assays, respectively. The efficacy infections was assessed Galleria mellonella survival assay. Results: Using fractional...
This prospective cohort study analyzed the immune response to COVID-19 mRNA vaccines in lung transplant recipients (LuTRs) compared healthy controls (HCs) at a 6-month follow-up.After first two doses of either BNT162b2 or mRNA-1273, SARS-CoV-2 antibodies were measured LuTRs (n = 57) and sex- age-matched HCs 57). Antibody kinetics during follow-up effect third vaccine dose evaluated. Humoral responses assessed using Elecsys® Anti-SARS-CoV-2 S immunoassay. In 16 LuTRs, SARS-CoV-2-specific T...
Invasive Staphylococcus aureus infections are associated with a high burden of disease, case fatality rate and healthcare costs. Oxazolidinones such as linezolid tedizolid considered potential treatment choices for conditions involving methicillin resistance or penicillin allergies. Additionally, they being investigated inhibitors toxins in toxin-mediated diseases. In this study, were evaluated an vitro development model induction S. aureus. Whole genome sequencing was conducted to elucidate...
Abstract Purpose: The increasing prevalence of methicillin-resistant Staphylococcus aureus (MRSA) strains resistant to non-beta-lactam antimicrobials poses a significant challenge in treating severe MRSA bloodstream infections. This study explores resistance development and mechanisms isolates, especially after the first dalbavancin-resistant strain our hospital 2016. Methods: investigated 55 isolates (02/2015–02/2021) from University Hospital Medical Vienna, Austria. MICs dalbavancin,...
In-depth telephone interviews with defined contribution retirement plan providers, conducted by Mathew Greenwald & Associates in Summer 2011, reveal that most providers are working to educate their participants about Social Security and its role ensuring financial security retirement. Through website content, mailed materials, one-on-one meetings, seminars, receive basic information on how works benefit amount can vary based age at claiming. Most not able give specific, individual advice...
Solid organ transplant recipients (SOTRs) are considered to be at high risk for severe complications and even death when infected with COVID-19. 1 In heart (HTRs), COVID-19 is associated a mortality rate of up 25%. 2 Yet, some recently published data indicate similar safety profile but reduced immune responses mRNA vaccine in SOTRs compared from immunocompetent persons. 3e the humoral cellular after administration two doses vaccines (HTRs) against health controls (healthcare workers Medical...
Background: Patients with neuroimmunological disorders on anti-CD20 therapy are at increased risk of severe COVID-19. However, little is known about SARS-CoV-2 vaccine efficacy in this cohort. In particular, the impact B cell depletion humoral and cellular immune responses to vaccination remains poorly defined. No study has addressed delta variant immunocompromised individuals so far.Methods: prospective cohort we investigated serial samples from 164 after mRNA (82 patients 82 healthy...