A5067009043- Lipoproteins and Cardiovascular Health
- Renal Transplantation Outcomes and Treatments
- Systemic Lupus Erythematosus Research
- Platelet Disorders and Treatments
- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood groups and transfusion
- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Autoimmune Bullous Skin Diseases
- Monoclonal and Polyclonal Antibodies Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Immunodeficiency and Autoimmune Disorders
- Pharmacological Effects and Toxicity Studies
- Hemostasis and retained surgical items
- Organ Transplantation Techniques and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Urticaria and Related Conditions
- Diabetes and associated disorders
- Cancer, Lipids, and Metabolism
- Peripheral Neuropathies and Disorders
- Transplantation: Methods and Outcomes
- Eosinophilic Disorders and Syndromes
Austrian Atherosclerosis Society
2019-2023
Medical University of Vienna
2010-2020
Sigmund Freud University Vienna
2019
Vienna General Hospital
1992-2018
Arbeitsgemeinschaft für Klinische Ernährung
2015-2016
Barmherzige Schwestern Krankenhaus Wien
2010-2016
University of Vienna
1996-2007
University of Washington
2005
University of Birmingham
2002
Pediatric Nephrology of Alabama
2002
To evaluate the histopathologic changes influencing Doppler measurements of resistive index (RI) in renal arteries parenchymal diseases, 68 kidneys 34 consecutive patients with various forms diseases were studied by duplex ultrasound (duplex US) immediately before percutaneous biopsy. The RI, length, and cortical echogenicity correlated amount glomerular, interstitial, vascular graded on a scale from 0 to 100. resistance therefore RI are significantly prevalence arteriolosclerosis,...
Apheresis with different procedures and devices are used for a variety of indications that may have adverse events (AEs). The aim this study was to clarify the extent possible reasons various side effects based on data from multinational registry.The WAA-apheresis registry focus in total 50846 7142 patients (42% women). AEs were graded as mild, moderate (need medication), severe (interruption due AE) or death (due AE).More occurred during first versus subsequent (8.4 5.5%, respectively)....
Antibody-mediated rejection (AMR) frequently causes refractory graft dysfunction. This randomized controlled trial was designed to evaluate whether immunoadsorption (IA) is effective in the treatment of severe C4d-positive AMR. Ten out 756 kidney allograft recipients were included. Patients randomly assigned IA with protein A (N = 5) or no such option rescue after 3 weeks. Enrolled subjected tacrolimus conversion and, if indicated, 'anti-cellular' treatment. All IA-treated patients responded...
Blood group incompatibility in allogeneic BMT is common but does not appear to affect the outcome terms of incidence graft rejection or delayed engraftment. However, major ABO may be associated with prolonged erythroid aplasia.In a retrospective analysis 286 transplant recipients, prevalence aplasia, including pure RBC was determined.Patients receiving ABO-incompatible grafts showed significant delay reticulocyte engraftment (median, 32 days; range, 12-347) from that patients ABO-identical...
Coagulation inhibitors may occur as alloantibodies in patients with congenital factor deficiencies or autoantibodies a previously normal coagulation. We treated 10 VIII (three haemophiliacs and seven acquired inhibitors) one patient V inhibitor using extracorporeal immunoadsorption to immobilized antibodies against human immunoglobulins (Ig‐Therasorb). The initial titre was between 18 BU/ml 540 BU/ml. Nine had signs of bleeding. Eighty‐nine sessions were performed the 11 (8·1 ± 5·1 per...
Immunoadsorption (IAS) and therapeutic plasma exchange (TPE) are considered safe although fibrinogen is removed. To date no comparison of reduction associated risk bleeding in apheresis exists.Retrospective analysis TPE, three IAS adsorbers, combined TPE/IAS regarding incidence 67 patients (1,032 treatments).TPE reduced by 64 ± 11% 58 9%, leading to concentrations <100 mg/dl 20 17% treatments, respectively. decreased less than TPE (26 6%, p < 0.0001), resulting 1% treatments. The processed...
Anti-glomerular basement membrane (GBM) antibody disease may lead to acute crescentic glomerulonephritis with poor renal prognosis. Current therapy favours plasma exchange (PE) for removal of pathogenic antibodies. Immunoadsorption (IAS) is superior PE regarding efficiency antibody-removal and safety. Apart from anecdotal data, there no systemic analysis the long-term effects IAS on anti-GBM-disease kinetics.To examine effect high-frequency combined standard immunosuppression patient...
Kidney transplant recipients with a current positive complement-dependent cytotoxicity crossmatch (CDCXM) are at high risk for hyperacute rejection and graft loss. Immunoadsorption (IA) represents an efficient strategy to remove donor-specific alloantibodies. In this analysis, we evaluated effectiveness of peritransplant IA as anti-humoral overcome CDCXM in presensitized renal allograft recipients.Between 1999 2003, 40 cadaveric kidney (median CDC panel reactive antibody [PRA] level, 77%;...
Summary Despite the use of high‐dose systemic corticosteroids in combination with other immunosuppressants, some patients autoimmune bullous diseases only insufficient improvement is achieved. In these cases and acute severe disease, adjuvant immunoapheresis has been increasingly used. A consensus meeting was held mid‐2005 Hamburg, aiming at developing guidelines for treatment diseases.This paper summarizes experts‘ recommendations.
Potent antibody depletion techniques have paved the way to successful ABO-incompatible transplantation. Considering its efficiency regarding IgG removal, use of non-antigen-specific semi-selective immunoadsorption (IA) has been advocated. One attractive strategy overcome caveat incomplete IgM and interfere with complement activation could be adjunctive membrane filtration (MF) enhance removal macromolecules. To investigate IA plus MF, we conducted a randomized, controlled, cross-over trial...
Background. Recipient desensitization using blood group (BG)-specific immunoadsorption (ABO-IA) has proven to enable successful kidney transplantation across major ABO barriers. In this context, the efficiency of non-antigen-specific (semiselective) IA adsorbers not yet been established. The objective our study was quantify anti-A/B antibody depletion by protein A-, peptide ligand- and anti-human immunoglobulin-based semiselective in comparison ABO-IA. Methods. Eight ABO-IA-treated...
Background: Paraneoplastic pemphigus was first described in 1990 5 patients with extensive mucocutaneous erosions, a distinct set of autoantibodies, and underlying neoplasia.Since then, have been middle-aged, suffered from prognostically unfavorable malignant neoplasms, responded poorly to immunosuppressive agents.Observation: A 16-year-old boy examined oral halitosis that interfered his quality life, rapid weight loss.The suspected clinical diagnosis paraneoplastic confirmed by...
Systemic lupus erythematosus (SLE) is characterized by pathogenic autoantibodies, which can be removed extracorporeal procedures. While previous studies have shown short-term efficacy of immunoadsorption (IAS) in SLE, no information on long-term benefit and safety available. IAS was offered to patients with highly active renal disease when conventional therapy had failed. Eleven entered the prolonged programme were followed for up 10 years (mean 6.4 ± 3.5). Efficacy determined reduction...