A5045642972- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Acute Kidney Injury Research
- Erythropoietin and Anemia Treatment
- Neurological and metabolic disorders
- Muscle and Compartmental Disorders
- Vascular Procedures and Complications
- Pharmacological Effects and Toxicity Studies
- Iron Metabolism and Disorders
- Mechanical Circulatory Support Devices
- Renal function and acid-base balance
- Liver physiology and pathology
- Membrane-based Ion Separation Techniques
- Electrolyte and hormonal disorders
- Hemodynamic Monitoring and Therapy
- Adolescent and Pediatric Healthcare
- Complement system in diseases
- Venous Thromboembolism Diagnosis and Management
- Bipolar Disorder and Treatment
- Chronic Kidney Disease and Diabetes
- Electrical and Bioimpedance Tomography
- Metabolism and Genetic Disorders
- Childhood Cancer Survivors' Quality of Life
- Advanced MRI Techniques and Applications
- Electrospun Nanofibers in Biomedical Applications
Ghent University Hospital
2016-2025
Universitair Ziekenhuis Brussel
2023
Ghent University
2000-2017
Renal Research Institute
2012
Baxter (United States)
2012
University of Pisa
2012
Hospital de Poniente
2012
Fondation Hopale
2012
Onze Lieve Vrouwziekenhuis Hospital
2012
Austin Health
2008
Although different on-line convective removal strategies are available, there no studies comparing the efficiency of solute for three main options [post-dilution haemodiafiltration (post-HDF), pre-dilution (pre-HDF) and haemofiltration (pre-HF)] in parallel.In this study, we compared post-HDF (Polyflux 170), pre-HDF 170) pre-HF 210) 14 patients. Parallelism evaluation protocols consisted applying same blood flow, dialysis time effective convection (22.9 +/- 1.7 versus 22.2 2.0 L, P = NS)...
Chronic kidney disease (CKD) is characterized by chronic inflammation, considered a nontraditional risk factor for cardiovascular disease, the major cause of death in CKD. Symmetric dimethylarginine (SDMA) was recently demonstrated to induce reactive oxygen species monocytes. The present study further investigates inflammatory character SDMA compared with its structural counterpart asymmetric (ADMA).In vitro, effect on intracellular monocytic expression IL-6 and TNF-α studied followed an...
Apheresis with different procedures and devices are used for a variety of indications that may have adverse events (AEs). The aim this study was to clarify the extent possible reasons various side effects based on data from multinational registry.The WAA-apheresis registry focus in total 50846 7142 patients (42% women). AEs were graded as mild, moderate (need medication), severe (interruption due AE) or death (due AE).More occurred during first versus subsequent (8.4 5.5%, respectively)....
As protein binding of uremic toxins is not well understood, neither in chronic kidney disease (CKD) progression, nor during a hemodialysis (HD) session, we studied two cross-sectional studies. Ninety-five CKD 2 to 5 patients and ten stable were included. Blood samples taken either the routine ambulatory visit (CKD patients) or from blood inlet outlet line dialysis (HD patients). Total (CT) free concentrations determined p-cresylglucuronide (pCG), hippuric acid (HA), indole-3-acetic (IAA),...
Leukocyte activation and endothelial damage both contribute to cardiovascular disease, a major cause of morbidity mortality in CKD. Experimental vitro data link several protein-bound uremic retention solutes the modulation inflammatory stimuli, including endothelium leukocyte responses damage, corroborating observational vivo data. However, impact these toxins on crosstalk between leukocytes has not been assessed. This study evaluated effects acute continuous exposure levels indoxylsulfate...
Background. Innovative modifications have been introduced in several types of dialyser membranes to improve adequacy and permselectivity. Which aspects removal are modified how this relates different diffusive or convective strategies has, however, insufficiently investigated. Methods. In a prospective cross-over study, 14 chronic kidney disease (Stage 5D) patients were dialysed with second-generation high-flux (Polynephron™) comparison first-generation type (DIAPES®-HF800). Both dialysers...
Summary Background and objectives The degree of chronic kidney disease (CKD) is currently expressed in terms GFR, which can be determined directly or estimated according to different formulas on the basis serum creatinine and/or cystatin C measurements (estimated GFR [eGFR]). purpose this study was investigate whether eGFR values are representative for uremic toxin concentrations patients with degrees CKD. Design, setting, participants, & Associations between based solutes (mol wt range...
Background. Uraemic solutes accumulate in haemodialysis (HD) patients and interfere with physiological functions. Low-flux (LF) HD does not efficiently remove all uraemic compounds. We investigated whether large pore super-flux (SF) cellulose triacetate membranes (CTA) result a better removal of solutes. Methods. Eleven were dialysed consecutively LF-CTA SF-CTA during 3 weeks. Urea (UR), creatinine (CR), uric acid (UA), 3-carboxy-4-methyl-5-propyl-2-furanpropionic (CMPF), indole-3-acetic...
Hemodialysis aims at removing uremic toxins thus decreasing their concentrations. The present study investigated whether Kt/V(urea), used as marker of dialysis adequacy, is correlated with these Predialysis blood samples were taken before a midweek session in 71 chronic HD patients. Samples analyzed by colorimetry, HPLC, or ELISA for broad range solutes. Solute concentrations divided into four groups according to quartiles and also different other parameters potential impact, such age, body...
Protein-bound uraemic toxins (PBUT), dicarbonyl stress and advanced glycation end products (AGEs) associate with cardiovascular disease in dialysis. Intensive haemodialysis (HD) may have significant clinical benefits. The aim of this study was to evaluate the acute effects conventional extended HD haemodiafiltration (HDF) on reduction ratio (RR) total solute removal (TSR) PBUT, compounds AGEs. Thirteen stable patients randomly completed a single 4-h (HD4), HDF (HDF4), 8-h (HD8) (HDF8) 2-week...
Membranes with increasing pore size are introduced to enhance removal of large uremic toxins regular hemodialysis. These membranes might theoretically have higher permeability for bacterial degradation products. In this paper, products comparable composition different was investigated a new in vitro set-up that represents clinical flow and pressure conditions. Dialysis simulated an AK200 machine using low-flux, high-flux, medium cut-off (MCO) or high (HCO) device (n = 6/type). A...
Aim We studied various hemodialysis strategies for the removal of protein-bound solutes, which are associated with cardiovascular damage. Methods This study included 10 patients on standard (3x4h/week) high-flux hemodialysis. Blood was collected at dialyzer inlet and outlet several time points during a midweek session. Total free concentration solutes determined as well urea concentration. Per solute, two-compartment kinetic model fitted to measured concentrations, estimating plasmatic...
Purpose Malnutrition is prevalent in patients on dialysis and associated with morbidity mortality. Nutritional status can be assessed by a variety of biochemical physical parameters or nutritional assessment scores. Most these methods are expensive cumbersome to use not suitable for routine repetitive follow-up patients. The Mini Assessment (MNA) has short form screening set (MNA-SF), which would as tool, but been validated yet We aimed assess whether the MNA an appropriate tool identifying...
Purpose An arteriovenous fistula (AVF) is the first choice vascular access for hemodialysis. The AVF pathway can be seen as consisting of seven segments: proximal artery, distal arterial collaterals, vein, venous and anastomosis. While most studies describe complications without considering impact anastomosis (7th segment), present mathematical study investigated hemodynamic size angle on pressure drop flow distribution. Methods A side-to-end model was developed, an with a given...