A5063257464- Anesthesia and Sedative Agents
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Antifungal resistance and susceptibility
- Hemodynamic Monitoring and Therapy
- Fungal Infections and Studies
- Infective Endocarditis Diagnosis and Management
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal and Maternal Infections
- Antiplatelet Therapy and Cardiovascular Diseases
- Bacterial Identification and Susceptibility Testing
- Injury Epidemiology and Prevention
- Intraoperative Neuromonitoring and Anesthetic Effects
- Antibiotic Resistance in Bacteria
- Herpesvirus Infections and Treatments
- Clinical Nutrition and Gastroenterology
- Emergency and Acute Care Studies
- Blood Coagulation and Thrombosis Mechanisms
- Trauma and Emergency Care Studies
- Immune Response and Inflammation
- Climate Change and Health Impacts
Onze Lieve Vrouwziekenhuis Hospital
2006-2023
Stellenbosch University
2004
American Society of Anesthesiologists
2002
Ziekenhuisnetwerk Antwerpen Stuivenberg
1994
Alternative therapies for Staphylococcus aureus bacteremia and endocarditis are needed.We randomly assigned 124 patients with S. or without to receive 6 mg of daptomycin intravenously per kilogram body weight daily 122 initial low-dose gentamicin plus either an antistaphylococcal penicillin vancomycin. The primary efficacy end point was treatment success 42 days after the therapy.Forty-two therapy in modified intention-to-treat analysis, a successful outcome documented 53 120 who received as...
The expression and release of tissue factor is a major trigger for the activation coagulation in patients with sepsis. Tissue pathway inhibitor (TFPI) forms complex blood protease factors leading to inhibition thrombin generation fibrin formation.To determine if administration tifacogin (recombinant TFPI) provides mortality benefit severe sepsis elevated international normalized ratio (INR) assess safety sepsis, including low INR.A randomized, double-blind, placebo-controlled, multicenter,...
To evaluate whether TAK-242, a small-molecule inhibitor of Toll-like receptor-4-mediated signaling, suppresses cytokine levels and improves 28-day all-cause mortality rates in patients with severe sepsis.Randomized, double-blind, placebo-controlled trial.A total 93 intensive care units worldwide.A 274 sepsis shock or respiratory failure.Patients were randomly assigned to receive 30-min loading dose followed by 96-hr infusions placebo, TAK-242 1.2 mg/kg/day, 2.4 mg/kg/day.The primary...
Sugammadex rapidly reverses rocuronium-induced neuromuscular block. This study explored the dose-response relation of sugammadex given as a reversal agent at reappearance second muscle twitch after rocuronium- and vecuronium-induced A secondary objective was to investigate safety single doses sugammadex.In this two-center, phase II, dose-finding study, 80 patients (age >or= 18 yr, American Society Anesthesiologists physical status I or surgery 60 min requiring relaxation for intubation) were...
Objective Platelet-activating factor (PAF) and structurally-related oxidized phospholipids are proinflammatory mediators in systemic inflammatory states such as severe sepsis. The enzyme platelet-activating acetylhydrolase (PAF-AH) rapidly degrades PAF into inactive metabolites. Reduced PAF-AH activity has been observed patients with sepsis may contribute to their response organ dysfunction. A previous clinical trial recombinant human (rPAF-AH, Pafase) suggested that this treatment decrease...
To compare the type of pathogens isolated from patients with early-onset intensive care unit (ICU)-acquired pneumonia those late-onset ICU-acquired and to study risk factors for isolation that are potentially resistant multiple drugs.Prospective cohort study.Patients admitted ICU a 677-bed, university-affiliated teaching hospital in Belgium during 1997-2002.ICU-acquired was defined as case occurred 2 days or more after admission combination positive results radiologic analysis, clinical...
Objective: The objectives of this study were to evaluate safety (primary) and clinical efficacy (secondary) the humanized monoclonal anti-L-selectin antibody aselizumab in severely injured patients. Design: Prospective phase II, parallel group, double-blind, randomized, placebo-controlled trial. Setting: Fourteen medical intensive care units or trauma level I centers Belgium, Germany, Poland. Patients: Eighty-four patients with a sustained due blunt penetrating injury total Injury Severity...
Background Uptake of a second gas delivered mixture decreases the amount carrier and potent inhaled anesthetic leaving circle system through pop-off valve. The authors hypothesized that vaporizer settings required to maintain constant end-expired sevoflurane concentration (Etsevo) during minimal-flow anesthesia (MFA, fresh flow 0.5 l/min) or low-flow (LFA, 1 would be lower when is used in oxygen-nitrous oxide than oxygen. Methods Fifty-six patients receiving general were randomly assigned...
IntroductionIn order to find out the frequency rates of domestic and wild animal bites as well evaluation prevalence rabies disease in human population Province Kerman, a retrospective study was designed analyze statistically collected recorded data related this project.Methods This conducted within framework MPVM student research projects by means collaboration between
Case Report A 12-year-old boy, of Congolese roots and without medical history, first presented to our Emergency Department 3 days after blunt trauma the left ankle. The boy represented on two more occasions in next due ongoing pain. On last occasion he with severe hypoglycaemia. He was diagnosed septic shock, secondary subperiosteal abscess formation / osteomyelitis patient transferred paediatric intensive care unit where appropriate provided, including broad-spectrum antibiotic therapy,...
Introduction: We provide the out-of-hospital cardiac arrest (OHCA) data from January 1, 2015 up to December 31, 2019 Onze-Lieve-Vrouw Hospital Aalst (OLVA), Belgium. Methods: enrolled all OHCA cases served by mobile urgence group of OLVA. The four subgroups were composed as follow: “shockable and bystander witnessed”, non-bystander witnessed, “non-shockable witnessed” witnessed. Results: There 568 confirmed which 69 where suicides. Resuscitation was attempted in 328 cases. Witnessed happened...
Introduction: Emergency and disaster situations have a major impact on hospitals, some of which are already overloaded daily. The recent COVID-19 outbreak, attacks in Brussels, floods Wallonia influx Ukrainian refugees show that the risk facing involvement local hospitals (and stakeholders) is real. However, how implement their own hospital plan (HDP), position coordinator (HDC) real efficacy these measures remain unclear. Therefore, an evaluation tool with expert-consensus set Key...