A5057405792- Sarcoma Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Nanoplatforms for cancer theranostics
- Parathyroid Disorders and Treatments
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Renal Transplantation Outcomes and Treatments
- Iron Metabolism and Disorders
- TGF-β signaling in diseases
- Pancreatic function and diabetes
- Muscle and Compartmental Disorders
- interferon and immune responses
- Axon Guidance and Neuronal Signaling
- Molecular Biology Techniques and Applications
- Liver Diseases and Immunity
- Bone Tumor Diagnosis and Treatments
- Neurofibromatosis and Schwannoma Cases
- Glioma Diagnosis and Treatment
- Developmental Biology and Gene Regulation
- Liver Disease and Transplantation
- Growth Hormone and Insulin-like Growth Factors
- Photodynamic Therapy Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Cell Adhesion Molecules Research
- Magnesium in Health and Disease
Comprehensive Cancer Center Vienna
2021-2024
Medical University of Vienna
2021-2024
Krankenhaus der Elisabethinen
2006-2020
Universitätsklinik Balgrist
2014-2017
University of Zurich
2014-2015
TU Dresden
2012
Deutsche Forschungsgemeinschaft
2012
Antibody-mediated rejection (AMR) frequently causes refractory graft dysfunction. This randomized controlled trial was designed to evaluate whether immunoadsorption (IA) is effective in the treatment of severe C4d-positive AMR. Ten out 756 kidney allograft recipients were included. Patients randomly assigned IA with protein A (N = 5) or no such option rescue after 3 weeks. Enrolled subjected tacrolimus conversion and, if indicated, 'anti-cellular' treatment. All IA-treated patients responded...
We show that after tail amputation in Ambystoma mexicanum (Axolotl) the correct number and spacing of dorsal root ganglia are regenerated. By transplantation spinal cord tissue nonclonal neurospheres, we central represents a source peripheral nervous system cells. Interestingly, melanophores migrate from preexisting precursors skin. Finally, demonstrate implantation clonally derived neurosphere can result reconstitution all examined cell types regenerating cord, suggesting derivation with...
Liver fibrosis is the static and main (70%-80%) component of portal hypertension (PH). We investigated dynamic components PH by a three-dimensional analysis based on correlation hepatic collagen proportionate area (CPA) with pressure (PP) in animals or HVPG patients.Different animal models (bile duct ligation: n = 31, carbon tetrachloride: 12, thioacetamide: choline-deficient high-fat diet: 12) patients confirmed single etiology cholestatic (primary biliary cholangitis/primary sclerosing...
ABSTRACT Background Bone fragility fractures are associated with high morbidity and mortality. This study analysed the association between current biochemical parameters of chronic kidney disease–mineral bone disorders (CKD-MBD) in COSMOS (Current management Of Secondary hyperparathyroidism: a Multicentre Observational Study) project. Methods is 3-year, multicentre, open cohort, prospective, observational carried out 6797 haemodialysis patients (227 centres from 20 European countries). The...
Primary bone cancers are among the deadliest cancer types in adolescents, with osteosarcomas being most prevalent form. Osteosarcomas commonly treated multi-drug neoadjuvant chemotherapy and therapy success as well patient survival is affected by presence of tumor suppressors. In order to assess prognostic value tumor-suppressive biomarkers, primary osteosarcoma tissues were analyzed prior after chemotherapy.We constructed a tissue microarray from high grade samples, consisting 48 naïve...
Current osteosarcoma therapies cause severe treatment-related side effects and chemoresistance, have low success rates. Consequently, alternative treatment options are urgently needed. Photodynamic therapy (PDT) is a minimally invasive, local with proven clinical efficacy for variety of tumor types. PDT cytotoxic, provokes anti-vascular stimulates cell targeting mechanisms the immune system and, consequently, has potential as novel patients. This study investigated uptake dark- phototoxicity...
Abstract Background Diffuse hemispheric glioma, H3 G34R/V-mutant (DHG-H3G34) is characterized by poor prognosis and lack of effective treatment options. DHG-H3G34R further harbor deactivation alpha-thalassemia/mental retardation syndrome X-linked protein (ATRX; DHG-H3G34R_ATRX) suggesting a unique interaction these 2 oncogenic alterations. In this study, we dissect their cell biological interplay, investigate the impact on telomere stabilization, consequently validate targeted therapy...
ΔNp63, a splice variant of p63, is overexpressed and exhibits oncogenic activity in many cancers including pancreatic breast cancer promotes cell survival by inhibiting apoptosis. Despite its role tumorigenesis, mechanistic ΔNp63 mediated function osteosarcoma poorly understood.The expression levels p63 isoforms lines were identified using quantitative techniques. Expression profiling microarray, siRNA loss-of-function, chromatin immunoprecipitation assays employed to identify novel ΔNp63α...
Calcification propensity is associated with the risk for cardiovascular events and death in end-stage renal disease patients. Here we investigated effect of lowering serum phosphate oral binder therapy on calcification propensity.
Osteosarcoma is the most common primary malignancy of bone. Its treatment relies on administration neoadjuvant and adjuvant chemotherapy combined with surgery. Alternative to intravenous (i.v.) chemotherapeutic drugs, clinical studies also evaluated benefit intraarterial (i.a.) administrations. However, conflicting results were obtained when both routes cisplatin (CDDP), a gold standard drug in osteosarcoma treatment, compared. In order overcome confounding factors, we mouse model...
The targeted delivery of tumor necrosis factor-α (TNF-α) with antibodies specific to splice isoforms fibronectin [e.g., F8-TNF, the extra-domain A (EDA) domain fibronectin] has already shown efficacy against experimental sarcomas but not yet been investigated in orthotopic sarcomas. Here, we F8-TNF a syngeneic K7 M2–derived model osteosarcoma as treatment pulmonary metastases, most frequent cause osteosarcoma-related death. Immunofluorescence on human tissue confirmed presence EDA primary...
FAM3C/ILEI is an important factor in epithelial-to-mesenchymal transition (EMT) induction, tumor progression and metastasis. Overexpressed many cancers, elevated ILEI levels secretion correlate with poor patient survival. Although ILEI’s causative role invasive growth metastasis has been demonstrated several cellular models, there are no available transgenic mice to study these effects the context of a complex organism. Here, we describe generation initial characterization Tet-ON inducible...
Abstract BACKGROUND Neurofibromatosis Type 1 (NF1) is a genetic disorder characterized by mutations and dysfunctional expression of neurofibromin gene, critical tumor-suppressor gene. NF1’s complex pathophysiology involves dysregulation the RAS-MAPK signaling pathway, resulting in sustained MAPK signaling. Among others, spectrum clinical features includes low-grade tumors (e.g. plexiform neurofibromas (pNFs)) malignant peripheral nerve sheath (MPNST). While surgical removal common, total...
ABSTRACT Background Ageing often affects biomarker production. Yet, clinical/optimal thresholds to guide clinical decisions do not consider this. Serum albumin decreases with age, but hypoalbuminaemia is defined as serum <4.0 g/dl. This study explores whether age might affect levels and its association mortality in haemodialysis patients. Methods COSMOS (Current Management of Secondary Hyperparathyroidism: a Multicentre Observational Study) prospective, open-cohort, observational...
Abstract Osteosarcoma (OS) is a malignancy of bone and five-year survival rates are still at low 20% if metastatic disease present. Metastatic OSs most frequently metastasize to the lung. TNF-α powerful cytokine already shown be active against many cancers. Nevertheless, highly toxic clinically relevant concentrations. To overcome this limitation, targeted forms can used. In study, targeting achieved through linking antibody fragment F8, EDA-domain fibronectin. test efficacy F8-TNF-α OS, we...