A5028375197- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Vitamin D Research Studies
- Dermatological and COVID-19 studies
- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Iron Metabolism and Disorders
- Nutrition and Health in Aging
- MicroRNA in disease regulation
- Hemostasis and retained surgical items
- Electrolyte and hormonal disorders
- Blood Coagulation and Thrombosis Mechanisms
- Magnesium Alloys: Properties and Applications
- Muscle and Compartmental Disorders
- Hemophilia Treatment and Research
Central University Hospital of Asturias
2020-2024
Universidad de Oviedo
2020-2024
Instituto de Investigación Sanitaria del Principado de Asturias
2021-2023
Vitamin D status has been implicated in COVID-19 disease. The objective of the COVID-VIT-D trial was to investigate if an oral bolus cholecalciferol (100,000 IU) administered at hospital admission influences outcomes moderate-severe In same cohort, association between baseline serum calcidiol levels with also analysed.The is a multicentre, international, randomised, open label, clinical conducted throughout 1 year. Patients older than 18 years disease requiring hospitalisation were included....
In chronic kidney disease, the activation of renin-angiotensin-aldosterone system (RAAS) and renal inflammation stimulates fibrosis progression to end-stage disease. The low levels vitamin D receptor (VDR) its activators (VDRAs) contribute worsen secondary hyperparathyroidism fibrosis.The 7/8 nephrectomy model experimental failure (CRF) was used examine anti-fibrotic effects treatment with two VDRAs, paricalcitol calcitriol, at equivalent doses (3/1 dose ratio) during 4 weeks.CRF increased...
MicroRNAs (miRs) regulate vascular calcification (VC), and their quantification may contribute to suspicion of the presence VC.The study was performed in four phases. Phase 1: miRs sequencing rat calcified non-calcified aortas. 2: with highest rate change, plus miR-145 [the most abundant miR smooth muscle cells (VSMCs)], were validated aortas serum from rats without VC. 3: selected analyzed epigastric arteries kidney donors recipients, samples general population. 4: VSMCs exposed different...
ABSTRACT Background Ageing often affects biomarker production. Yet, clinical/optimal thresholds to guide clinical decisions do not consider this. Serum albumin decreases with age, but hypoalbuminaemia is defined as serum <4.0 g/dl. This study explores whether age might affect levels and its association mortality in haemodialysis patients. Methods COSMOS (Current Management of Secondary Hyperparathyroidism: a Multicentre Observational Study) prospective, open-cohort, observational...
The most severe clinical manifestations of the Coronavirus disease 2019 (COVID-19), caused by acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are due to an unbalanced immune response and a pro-thrombotic hemostatic disturbance, with arterial hypertension or diabetes as acknowledged risk factors. While waiting for specific treatment, management hospitalized patients is still matter debate, effectiveness treatments manage comorbidities has been questioned. In this study, we aim assess...
Objetivos Valorar si la fuerza de agarre y dificultad para realizar actividades cotidianas podrÃan ser predictores caÃdas fracturas osteoporóticas.
Hemophilia A (HA) is a rare bleeding disorder caused by factor VIII (FVIII) deficiency due to various genetic mutations in the F8 gene. The disease severity inversely correlates with plasma levels of functional FVIII. treatment HA patients based on FVIII replacement therapy, either following prophylactic or on-demand regime, depending at diagnosis and patient's clinical manifestations. hemorrhagic manifestations are widely variable amongst patients, who may require monitoring re-adjustment...