A5006572893- Biosimilars and Bioanalytical Methods
- Psoriasis: Treatment and Pathogenesis
- Inflammatory Bowel Disease
- Pain Mechanisms and Treatments
- Chronic Lymphocytic Leukemia Research
- Dermatology and Skin Diseases
- Photodynamic Therapy Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Nonmelanoma Skin Cancer Studies
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical studies and practices
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Lupus Erythematosus Research
- Skin Protection and Aging
- Thermoregulation and physiological responses
- Microscopic Colitis
- Complementary and Alternative Medicine Studies
- Sympathectomy and Hyperhidrosis Treatments
- Pharmacology and Obesity Treatment
- Infectious Diseases and Mycology
- Antiplatelet Therapy and Cardiovascular Diseases
- Immunodeficiency and Autoimmune Disorders
- Hair Growth and Disorders
- Cancer Research and Treatments
- Health, psychology, and well-being
Akershus University Hospital
2019-2025
University of Wisconsin–Madison
2024-2025
Norwegian University of Science and Technology
2011-2019
St Olav's University Hospital
2017
Hannover Re (Germany)
2016
Oslo University Hospital
1991-2013
Bispebjerg Hospital
2011
University of Copenhagen
2011
Stavanger University Hospital
2011
Uppsala University Hospital
2011
<h3>Importance</h3> Proactive therapeutic drug monitoring (TDM), consisting of individualized treatment based on scheduled assessments serum levels, has been proposed as an alternative to standard therapy optimize efficacy and safety infliximab other biologic drugs. However, it remains unclear whether proactive TDM improves clinical outcomes during maintenance therapy. <h3>Objective</h3> To assess with by preventing disease worsening compared without TDM. <h3>Design, Setting,...
<h3>Importance</h3> Proactive therapeutic drug monitoring (TDM), defined as individualized dosing based on scheduled of serum levels, has been proposed an alternative to standard therapy maximize efficacy and safety infliximab other biological drugs. However, whether proactive TDM improves clinical outcomes when implemented at the time initiation, compared with therapy, remains unclear. <h3>Objective</h3> To assess during initiation treatment without TDM. <h3>Design, Setting,...
Quality of life measures are widely used in dermatology as well rheumatology, but there no large studies taking arthritis into consideration when studying quality psoriasis. The aim this study was to investigate psoriasis-related a sample members the psoriasis associations from Nordic countries including an arthritis-related evaluation. prevalence reported within groups also estimated. An Arthritis Disability Index suitable for parallel use together with Finlay's Psoriasis constructed. A...
Actinic keratoses (AKs) are common dysplastic skin lesions that may differentiate into invasive squamous cell carcinomas. Although a superior cosmetic outcome of photodynamic therapy (PDT) is advantageous compared with equally effective treatments such as cryotherapy and curettage, the inconvenience clinic attendance discomfort during significant drawbacks. Daylight-mediated PDT could potentially reduce these serve an alternative to conventional PDT.To compare efficacy methyl...
Summary Background Photodynamic therapy (PDT) is an attractive for nonmelanoma skin cancers and actinic keratoses (AKs). Daylight‐mediated PDT a simple tolerable treatment procedure PDT. Methyl aminolaevulinate (MAL)‐PDT approved the of thin or nonhyperkeratotic AKs on face scalp. However, thick AK lesions are often treated as well when present in field‐cancerized area. Objectives In randomized multicentre study to evaluate efficacy daylight‐mediated different severity grades AKs. Methods...
The 52-week, randomized, double-blind, noninferiority, government-funded NOR-SWITCH trial demonstrated that switching from infliximab originator to less expensive biosimilar CT-P13 was not inferior continued treatment with originator. extension aimed assess efficacy, safety and immunogenicity in patients on throughout the 78-week study period (maintenance group) versus switched at week 52 (switch group). primary outcome disease worsening during follow-up based disease-specific composite...
Journal Article Quality of life in 6497 Nordic patients with psoriasis Get access R. Zachariae, Zachariae Psycho‐oncology Research Unit, Aarhus University Hospital, Aarhus, Denmark Professor Robert Barthsgade 5,3, DK8200 N, Denmark. E‐mail: bzach@aaa.dk Search for other works by this author on: Oxford Academic Google Scholar H. Department Dermatology, K. Blomqvist, Blomqvist Helsinki Helsinki, Finland S. Davidsson, Davidsson Hospital Reykjavik, Iceland L. Molin, Molin Örebro Medical Centre...
Background. Organ transplant recipients on long-term immunosuppressive therapy are at increased risk of non-melanoma skin lesions. Repeated field photodynamic using topical methyl aminolevulinate (MAL) may have potential as a preventive treatment. Methods. This open randomized, intrapatient, comparative, multicenter study included 81 with 889 lesions (90% actinic keratoses (AK)]. In each patient, the treatment was initially administered to one 50 cm2 area face, scalp, neck, trunk, or...
Primary cutaneous posttransplant lymphoproliferative disorders (PTLD) are rare. This retrospective, multicenter study of 35 cases aimed to better describe this entity. Cases were (re)-classified according the WHO-EORTC or WHO 2008 classifications lymphomas. Median interval between first transplantation and diagnosis was 85 months. Fifty-seven percent patients had a kidney transplant. Twenty-four (68.6%) classified as primary T cell lymphoma (CTCL) 11 (31.4%) B PTLD. Mycosis fungoides (MF)...
Prolonged follow-up data on topical photodynamic therapy (PDT) in basal cell carcinoma (BCC) are necessary for a full evaluation of its effect and comparison with conventional treatment methods.To assess 10-year long-term PDT efficacy primary recurrent BCC to evaluate clinical histopathological factors which may be associated failure.We performed longitudinal study 60 histologically verified BCCs 44 patients treated curettage one or two sessions dimethylsulphoxide (DMSO)-supported...
ABSTRACT Objectives The purpose of the study was to investigate perceived influence stress on psoriasis onset and disease severity in a large sample psoriatics compare reactors non‐reactors with respect psoriasis‐related stress, severity, family history sociodemographic factors. Patients/methods A total 5795 members Nordic associations 702 patients recruited from dermatologists or university clinics were asked whether their first outbreak occurred during times worry stress. They also rate...
Few studies have investigated subjective sensory skin symptoms in patients with psoriasis. The aim of this study was to investigate prevalence and characteristics psoriasis-related pain discomfort, evaluate differences demographic/clinical among or without symptoms. A total 139 recruited for exploratory, descriptive, cross-sectional study. Data were obtained through interviews questionnaires. While 42.6% reported pain, 36.7% discomfort. Mean average symptom intensity score (0-10 numeric...
Destructive periodontitis is one of the most frequent and widespread bacterial infections in humans. Psoriasis a common condition general population. Since both psoriasis periodontal diseases are characterized by an exaggerated response immune system to epithelial surface microbiota, there may possibly be association between these two conditions. The aim present pilot study was investigate prevalence disease patients compared healthy controls.Dental bite-wing X-rays were obtained from 155...
A variety of studies have shown beneficial effects different types phototherapy in skin disorders. Such therapy leads to enhanced cutaneous vitamin D synthesis, which may be one the mechanisms action. Furthermore, another nutrient, folate, can probably also influenced by UV radiation.The aim our study was investigate influence low-dose narrowband UVB (nUVB) patients with psoriasis, atopic eczema and other disorders on serum levels 25(OH) (the marker for status) erythrocyte-folate.25(OH)...
Abstract Background Patients with psoriasis commonly report severe sensory skin symptoms, sleep disturbance, psychological distress and impaired health related quality of life (HRQoL). However, the complex associations among these factors are poorly investigated in this patient group. Objectives The purpose study was to investigate association between pain or discomfort HRQoL, explore whether disturbance were mediators associations. Methods A total 139 patients from a university hospital...
Abstract Background Anti‐drug antibodies (ADAb) frequently form early in the treatment course of infliximab and other tumour necrosis factor (TNF) inhibitors, leading to failure adverse events. Objective To identify risk factors for ADAb phase treatment. Methods Patients ( n = 410) with immune‐mediated inflammatory diseases who initiated were included 38‐week Norwegian Drug Monitoring Trial (NOR‐DRUM) A randomised 1:1 therapeutic drug monitoring (TDM) or standard therapy. Serum levels...
Background Topical photodynamic therapy (PDT) is an approved and widely used treatment for low-risk basal cell carcinoma (BCC), comprising two sessions with interval of 1 week. Simplification the course can be cost-effective, easier to organize, cause less discomfort patients. Methods findings We performed investigator-initiated, single-blind, non-inferiority, randomized controlled multicentre study objective investigating whether a simpler more flexible PDT regimen was not >10% effective...
Gain-of-function variants in the voltage-gated sodium channel Nav1.7, encoded by SCN9A gene, have previously been identified patients with erythromelalgia, a clinical diagnosis defined intermittent attacks of painful, hot, swollen, and red skin, predominantly involving hands feet. Symptoms are induced or aggravated warming relieved cooling. In primary erythromelalgia there is no known underlying disease. This study investigated frequency cohort collected at single centre, examined signs...
Abstract Background: The mesenchymal transcript factors is a receptor tyrosine kinase that when dysregulated or overexpressed can stimulate oncogenesis. Alterations in MET are found 5% of non-small cell lung cancer but also head and neck cancers resistant to inhibitors targeting other oncogenic drivers. Our objective evaluate novel, camelid-derived, binding antibody as potential theranostic agent used expressing cancers. Methods: anti-MET VHH camelid antibody, 1E7-Fc, was identified from...
Abstract Background Infliximab (INX) and other tumour necrosis factor inhibitors (TNFi) have revolutionised the treatment of several immune mediated inflammatory diseases. Still, many patients do not respond sufficiently to therapy or lose efficacy over time. The large interindividual variation in serum drug concentrations on standard doses development anti-drug antibodies are thought be major reasons for failures. Therapeutic monitoring (TDM), an individualised strategy based systematic...
In Brief Seven patients diagnosed with erythromelalgia (EM) were investigated by microneurography to record from unmyelinated nerve fibers in the peroneal nerve. Two had characterized variants of sodium channel Nav1.7 (I848T, I228M), whereas no mutations coding regions Navs found 5 EM. Irrespective mutations, more than 50% silent nociceptors EM showed spontaneous activity. patient mutation I848T, all nociceptors, but not sympathetic efferents, displayed enhanced early subnormal conduction...