Maitane Aranzamendi
A5074851025- Viral Infections and Immunology Research
- Antibiotic Resistance in Bacteria
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 and COVID-19 Research
- Antibiotics Pharmacokinetics and Efficacy
- Pneumocystis jirovecii pneumonia detection and treatment
- Immunodeficiency and Autoimmune Disorders
- Escherichia coli research studies
- Enterobacteriaceae and Cronobacter Research
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Pneumonia and Respiratory Infections
- Vibrio bacteria research studies
- Eosinophilic Esophagitis
- Herpesvirus Infections and Treatments
- Animal Disease Management and Epidemiology
- SARS-CoV-2 detection and testing
- Infection Control in Healthcare
- Infections and bacterial resistance
- Infectious Disease Case Reports and Treatments
- Neonatal Health and Biochemistry
- Bacterial Infections and Vaccines
- COVID-19 and healthcare impacts
Osakidetza
2024
University of the Basque Country
2021-2024
Basque Government
2024
Hospital de Cruces
2015-2022
BioCruces Health research Institute
2019-2022
Consejería de Salud y Consumo
2020-2021
Biogipuzkoa Health Research Institute
2021
Fundación Marques de Valdecilla
2012-2013
Abstract Solid organ transplant (SOT) recipients are especially at risk of developing infections by multidrug resistant bacteria (MDR). In this study, the biofilm-forming capability 209 MDR strains ( Escherichia coli n = 106, Klebsiella pneumoniae 78, and Enterobacter spp. 25) isolated from rectal swabs in first 48 hours before or after kidney (93 patients), liver (60 patients) kidney/pancreas transplants (5 were evaluated using a microplate assay. Thirty-nine 170 post-transplant. Overall,...
We report a rapid increase in enterovirus D68 (EV-D68) infections, with 139 cases reported from eight European countries between 31 July and 14 October 2021. This upsurge is line the seasonality of EV-D68 was presumably stimulated by widespread reopening after COVID-19 lockdown. Most were identified September, but more are to be expected coming months. Reinforcement clinical awareness, diagnostic capacities surveillance urgently needed Europe.
ABSTRACT We conducted a prospective multicenter study in Spain to characterize the mechanisms of resistance amoxicillin-clavulanate (AMC) Escherichia coli . Up 44 AMC-resistant E. isolates (MIC ≥ 32/16 μg/ml) were collected at each seven participant hospitals. Resistance characterized by PCR and sequencing. Molecular epidemiology was studied pulsed-field gel electrophoresis (PFGE) multilocus sequence typing. Overall AMC 9.3%. The detected 257 OXA-1 production (26.1%), hyperproduction...
IntroductionEnterovirus A71 (EV-A71) is an emerging pathogen that causes a wide range of disorders including severe neurological manifestations. In the past 20 years, this virus has been associated with large outbreaks hand, foot and mouth disease complications in Asia-Pacific region, while Europe mainly sporadic cases have reported. spring 2016, however, EV-A71 outbreak was reported Catalonia spread further to other Spanish regions.AimOur objective investigate epidemiology clinical...
During 2014, enterovirus D68 (EV-D68) outbreaks were described globally, causing severe respiratory diseases in children and, some cases, subsequent paralysis. In this study, the type characterization of (EV) detected illnesses and epidemiology clinical association EV-D68 infections Spain over a five-year period described. A total 546 EV-positive samples from hospitalized patients with included. was most frequently (46.6%, 191/410 typed EV). Other EV species (25.1%), B (27.8%) C (0.5%) also...
Infections caused by carbapenem-resistant Acinetobacter baumannii are a global threat causing high number of fatal infections. This microorganism can also easily acquire antibiotic resistance determinants, making the treatment infections big challenge, and has ability to persist in hospital environment under wide range conditions. The objective this work was study molecular epidemiology genetic characteristics two blaOXA24/40Acinetobacter outbreaks (2009 2020-21) at tertiary Northern Spain....
Objetives The aim of this study was to identify CMV drug resistance mutations (DRM) in solid organ transplant (SOT) recipients with suspected comparing next-generation sequencing (NGS) Sanger and assessing risk factors the clinical impact resistance. Methods Using as reference method, we prospectively assessed ability NGS detect DRM UL97 UL54 genes a nationwide observational from September 2013 August 2016. Results Among 44 patients recruited, 14 were detected by 12 (27%) 20 NGS, 16 (36%)....
ABSTRACT Two hundred twelve patients with colonization/infection due to amoxicillin-clavulanate (AMC)-resistant Escherichia coli were studied. OXA-1- and inhibitor-resistant TEM (IRT)-producing strains associated urinary tract infections, while OXA-1 producers chromosomal AmpC hyperproducers bacteremic infections. AMC resistance in E. is a complex phenomenon heterogeneous clinical implications.
Abstract The objective of this study was to analyse the mechanisms resistance carbapenems and other extended-spectrum-β-lactams determine genetic relatedness multidrug-resistant Enterobacterales (MDR-E) causing colonization or infection in solid-organ transplantation (SOT) recipients. Prospective cohort kidney (n = 142), liver 98) kidney/pancreas 7) transplant recipients between 2014 2018 seven Spanish hospitals. We included 531 MDR-E isolates from rectal swabs obtained before weekly for 4–6...
Abstract Background This study describes the genotypic and phenotypic characterization of novel human cytomegalovirus (HCMV) genetic variants a cohort 94 clinically resistant HCMV patients. Methods results Antiviral-resistant mutations were detected in UL97, UL54, UL56 target genes 25 (26.6%) The genotype-phenotype correlation resolved status 5 uncharacterized UL54 deoxyribonucleic acid polymerase (G441S, A543V, F460S, R512C, A928T) 2 terminase (F345L, P800L) found clinical isolates. A928T...
Rhodococcus equi is an opportunistic human pathogen associated with immunosuppressed people. While the interaction of R. macrophages has been comprehensively studied, little known about its interactions non-phagocytic cells. Here, we characterized entry process this bacterium into lung epithelial The invasion inhibited by nocodazole and wortmannin, suggesting that phosphatidylinositol 3-kinase pathway microtubule cytoskeleton are important for invasion. Pre-incubation a rabbit anti -R....
Enterobacteria species are common causes of hospital-acquired infections, which associated with high morbidity and mortality rates. Immunocompromised patients such as solid organ transplant (SOT) recipients especially at risk because they frequently exposed to antibiotics in the course their treatments. In this work, we used a collection 106 Escherichia coli, 78 Klebsiella pneumoniae, 25 Enterobacter spp., 24 Citrobacter spp. multidrug resistant strains isolated from (hepatic, renal or...
Objective To analyse the impact of blood enterovirus and human parechovirus PCR (ev-PCR) testing in young infants with fever without a source (FWS). Design Observational study, subanalysis prospective registry. Setting Paediatric emergency department. Patients Infants ≤90 days age FWS seen between September 2015 August 2019 ev-PCR, urine cultures dipstick test performed. Main outcome measures Prevalence invasive bacterial infection (IBI: pathogen or cerebrospinal fluid) positive negative...
ABSTRACT The COVID-19 pandemic has shaken the world since beginning of 2020. Spain is among European countries with highest incidence disease during first wave. We established a multidisciplinar consortium to monitor and study evolution epidemic, aim contributing decision making stopping rapid spreading across country. present results for 2170 sequences from wave SARS-Cov-2 epidemic in representing 12% diagnosed cases until 14 th March. This effort allows us document at least 500 initial...
Quantitative reverse transcription PCR (RT-qPCR) is the leading tool to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given that it will almost certainly continue coexist with other viruses in coming years, our study aimed design a multiplex system not affected by supplier outages and reduced cost compared existing commercially available kits.In this study, combinations of four primers/probe sets were used construct flexible RT-qPCR assay which capable discriminating...
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We carried out a retrospective cohort study of 271 previously healthy children younger than 14 years old diagnosed with invasive bacterial infection in an emergency department. Of them, 72 (26.6%) had previous visits to the Not identifying and not administering antibiotics on first visit was associated severe outcome.