A5101685196- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Antibiotic Use and Resistance
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- HIV-related health complications and treatments
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Surgical site infection prevention
- Management, Economics, and Public Policy
- Streptococcal Infections and Treatments
- Nosocomial Infections in ICU
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 and healthcare impacts
- COVID-19 diagnosis using AI
- Long-Term Effects of COVID-19
- Systemic Lupus Erythematosus Research
- Urinary Tract Infections Management
- Tuberculosis Research and Epidemiology
- Liver Disease and Transplantation
Istituti Ospitalieri di Cremona
2016-2025
Johns Hopkins University
2024
Azienda Socio Sanitaria Territoriale di Cremona
2018-2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2023
World Health Organization
2022
Ospedale Maggiore di Lodi
2022
University of Modena and Reggio Emilia
2022
Centro Studi GISED
2021
Infectious Disease Consultants
2021
Ministry of Internal Affairs of the Russian Federation
2018
We performed a multicentre retrospective cohort study including 606,649 acute inpatient episodes at 10 European hospitals in 2010 and 2011 to estimate the impact of antimicrobial resistance on hospital mortality, excess length stay (LOS) cost. Bloodstream infections (BSI) caused by third-generation cephalosporin-resistant Enterobacteriaceae (3GCRE), meticillin-susceptible (MSSA) -resistant Staphylococcus aureus (MRSA) increased daily risk death (adjusted hazard ratio (HR) = 1.80; 95%...
In the night of February 20, 2020, first epidemic novel coronavirus disease (COVID-19) outside Asia was uncovered by identification its patient in Lombardy region, Italy. following weeks, experienced a sudden increase number ascertained infections and strict measures were imposed to contain spread.We analyzed official records cases occurred characterize epidemiology SARS-CoV-2 during early phase outbreak. A line list laboratory-confirmed set up later retrospectively consolidated, using...
Timely identification of COVID-19 patients at high risk mortality can significantly improve patient management and resource allocation within hospitals. This study seeks to develop validate a data-driven personalized calculator for hospitalized patients. De-identified data was obtained 3,927 positive from six independent centers, comprising 33 different Demographic, clinical, laboratory variables were collected hospital admission. The Mortality Risk (CMR) tool developed using the XGBoost...
Accurate assessment of risk factors for nosocomial acquisition colonization by antibiotic-resistant bacteria (ARB) is often confounded scarce data on antibiotic use. A 12-month, nested, multicenter cohort study was conducted. Target ARB were methicillin (meticillin)-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and ciprofloxacin-resistant Pseudomonas aeruginosa (CR-PA). Nares rectal swabs obtained before after starting antibiotics. Pulsed-field gel...
Embolic events are a major cause of morbidity and mortality in patients with infective endocarditis. We analyzed the database prospective cohort study SEI order to identify factors associated occurrence embolic develop scoring system for assessment risk embolism.We retrospectively 1456 episodes endocarditis from multicenter SEI. Predictors embolism were identified. Risk identified at multivariate analysis as predictive left-sided endocarditis, used development score: 1 point was assigned...
The development of COVID-19 syndrome in anticoagulated patients, and especially their admission to intensive-care units with acute severe respiratory (SARS-CoV-2), expose them specific problems related therapy, addition those associated the viral infection. Patients on VKA hospitalized SARS-CoV-2 show high instability PT INR due variability vitamin K metabolism, diet, fasting, co-medications, liver impairment, heart failure. DOAC are exposed under/over treatment caused by significant...
Rationale Pulse glucocorticoid therapy is used in hyperinflammation related to coronavirus disease 2019 (COVID-19). We evaluated the efficacy and safety of pulse intravenous methylprednisolone addition standard treatment COVID-19 pneumonia. Methods In this multicentre, randomised, double-blind, placebo-controlled trial, 304 hospitalised patients with pneumonia were randomised receive 1 g intravenously for three consecutive days or placebo dexamethasone. The primary outcome was duration...
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The aim of this study is the characterization and genomic tracing by phylogenetic analyses 59 new SARS-CoV-2 Italian isolates obtained from patients attending clinical centres in North Central Italy until end April 2020. All but one newly-characterized genomes belonged to lineage B.1, most frequently identified European countries, including Italy. Only a single sequence was found belong B. A mean 6 nucleotide substitutions per viral genome observed, without significant differences between...
Abstract Purpose Although dalbavancin is currently approved for the treatment of ABSSIs, several studies suggest its efficacy and tolerance as long-term therapy other off-label indications requiring prolonged intravenous antibiotic administration. Methods We conducted a prospective nationwide study use in real-life settings both analysing each case clinical microbiological characteristics infection safety treatments. Results During period (from December 2018 to July 2021), ID specialists...
Objectives We studied survival and associated risk factors in an Italian nationwide cohort of HIV-infected individuals after AIDS-defining cancer (ADC) or non-AIDS-defining (NADC) diagnosis the modern cART era. Methods Multi-center, retrospective, observational study HIV patients included MASTER Cohort with a from January 1998 to September 2012. Malignancies were divided into ADC NADC on basis Centre for Disease Control-1993 classification. Recurrence metastases excluded. Survivals estimated...
Objective To compare the effect of two strategies (enhanced hand hygiene vs meticillin-resistant Staphylococcus aureus (MRSA) screening and decolonisation) alone in combination on MRSA rates surgical wards. Design Prospective, controlled, interventional cohort study, with 6-month baseline, 12-month intervention washout phases. Setting 33 wards 10 hospitals nine countries Europe Israel. Participants All patients admitted to enrolled for more than 24 h. Interventions The compared were (1)...
Abstract Background Timely identification of COVID-19 patients at high risk mortality can significantly improve patient management and resource allocation within hospitals. This study seeks to develop validate a data-driven personalized calculator for hospitalized patients. Methods De-identified data was obtained 3,927 positive from six independent centers, comprising 33 different Demographic, clinical, laboratory variables were collected hospital admission. The Mortality Risk (CMR) tool...
Background: Vaccination of healthcare workers (HCWs) is a crucial element to overcome the COVID-19 pandemic. The aim this survey was assess attitudes, sources information and practices among Italian Healthcare in relation vaccination. Methods: From 19 February 23 April 2021, an anonymous voluntary questionnaire sent mailing list main National Health Service structures. Data were collected through SurveyMonkey platform. Results: A total 2137 HCWs answered. Hesitancy towards vaccination more...
The World Health Organization (WHO)'s Research and Development (R&D) Blueprint for Action to Prevent Epidemics, a plan of action, highlighted several infectious diseases as crucial targets prevention. These infections were selected based on thorough assessment factors such transmissibility, infectivity, severity, evolutionary potential. In line with this blueprint, the VACCELERATE Site Network approached disease experts rank listed in WHO R&D according their perceived risk triggering...
Immunological non-response (INR) despite virological suppression is associated with AIDS-defining events/death (ADE). Little known about its association serious non-AIDS-defining events (nADE).Patients highly-active antiretroviral therapy (HAART) <200 CD4+/μl and achieving HIV-RNA <50 copies/ml within 12 (±3) months were categorized as INR if CD4+ T-cell count at year 1 was <200/μl. Predictors of nADE (malignancies, severe infections, renal failure--ie, estimated glomerular filtration rate...
Currently, no data are available on the burden of morbidity and mortality in people with HIV-1 (PWH) harboring a 4-class drug-resistant (4DR) virus (nucleoside reverse transcriptase inhibitors, non-nucleoside protease integrase strand transfer inhibitors). The study aimed to assess incidence clinical events death this population. This was cohort PWH from PRESTIGIO Registry documented 4DR virus. Burden disease defined as occurrence any new event including an AIDS-defining (ADE) or...
The use of steroid therapy in potentially life-threatening neuroinvasive forms West Nile infection (WNND) is controversial. aim this study to assess the efficacy reducing intrahospital mortality, length stay, and neurological sequelae at discharge.This was a multicenter, retrospective, observational conducted 5 hospitals Northern Italy, headed by Fondazione IRCSS Policlinico San Matteo (Pavia). We extracted all patient data with WNND diagnoses, comparing patients who received treatment did...
Abstract Background Maternal sepsis presents challenges in early detection and treatment. A pregnancy-specific scoring system (MEOWS) management bundles for pregnant septic patients were recently introduced, but there is a lack of data on their effectiveness. Our study aims to assess the impact implementing Lombardy bundle puerperal patients.Table 1:Demographic clinical included Methods The SOS, retrospective multicenter across 7 Hospitals, focuses adult women diagnosed with according SCC...