Andrea Poli
A5001639111- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- COVID-19 Clinical Research Studies
- Mindfulness and Compassion Interventions
- Obsessive-Compulsive Spectrum Disorders
- Psychosomatic Disorders and Their Treatments
- Cerebrovascular and Carotid Artery Diseases
- COVID-19 and Mental Health
- Psychology of Moral and Emotional Judgment
- Long-Term Effects of COVID-19
- Lipoproteins and Cardiovascular Health
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Reproductive tract infections research
- Nutritional Studies and Diet
- Pneumocystis jirovecii pneumonia detection and treatment
- Acute Ischemic Stroke Management
- Proteoglycans and glycosaminoglycans research
- Antibiotic Use and Resistance
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
University of Pisa
2019-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2024
Policlinico San Matteo Fondazione
1992-2024
Ospedale Maggiore
2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2024
Azienda Ospedaliera Ospedale Maggiore
2024
Azienda Ospedaliera Ospedale Civile di Legnano
2024
Humanitas Mater Domini
2024
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2024
Vita-Salute San Raffaele University
2007-2023
A study in vitro of specimens human aortic and common carotid arteries was carried out to determine the feasibility direct measurement (i.e., not from residual lumen) arterial wall thickness with B mode real-time imaging. Measurements vivo by same technique were also obtained 10 young normal male subjects. Aortic samples classified as class (relatively normal) or (with one more atherosclerotic plaques). In all 85% a characteristic image composed two parallel echogenic lines separated...
Chondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity adult central nervous system and their digestion with chondroitinase reactivates plasticity. However structures that are unknown. There many changes as critical periods for close, including chondroitin proteoglycan core protein levels, glycosaminoglycan sulphation appearance of dense proteoglycan-containing perineuronal nets around neurons. We show formation is triggered by neuronal production cartilage link...
Patients with severe COVID-19 develop a life-threatening hyperinflammatory response to the virus. Interleukin (IL)-1 or IL-6 inhibitors have been used treat this patient population, but comparative effectiveness of these different strategies remains undetermined. We aimed compare IL-1 and inhibition in patients admitted hospital COVID-19, respiratory insufficiency, hyperinflammation.This cohort study included San Raffaele Hospital (Milan, Italy) defined as ratio partial pressure oxygen...
Objective: The REDISCOVER consensus conference aimed at developing and validate guidelines on the perioperative care of patients with borderline resectable (BR-) locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC). Summary Background Data: Coupled improvements in chemotherapy radiation, contemporary approach to surgery supports resection BR-PDAC and, a lesser extent, LA-PDAC. Guidelines outlining selection for these are lacking. Methods: Scottish Intercollegiate Network (SIGN)...
Abstract Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, social activities, correlate with reduced risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness action mechanisms elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We...
Biobanks are imperative infrastructures, particularly during outbreaks, when there is an obligation to acquire and share knowledge as quick possible allow for implementation of science-based preventive, diagnostic, prognostic, therapeutic strategies.We established a COVID-19 biobank with the aim collecting high-quality well-annotated human biospecimens, in effort understand pathogenic mechanisms underlying identify targets (COVID-BioB, NCT04318366). Here we describe our experience briefly...
Abstract The aim of this study was to evaluate the impact early treatment with corticosteroids on SARS-CoV-2 clearance in hospitalized COVID-19 patients. Retrospective analysis patients admitted San Raffaele Hospital (Milan, Italy) moderate/severe and availability at least two nasopharyngeal swabs. primary outcome time swab negativization. A multivariable Cox model fitted determine factors associated Of 280 included, 59 (21.1%) were treated steroids. Differences observed between steroid...
Research on the neuroscience of fear in both humans and non-humans has suggested that a lack acquisition safety cues might be biological hallmark posttraumatic stress disorder (PTSD). Danger perception, particular, feeling as one's own life is danger, thought to represent major predictor PTSD. Persistent danger perception concurrently associated with persistence safety. However, despite several research efforts, no validated psychometric tools exist regarding psychological unique core...
Abstract The REDISCOVER guidelines present 34 recommendations for the selection and perioperative care of borderline-resectable (BR-PDAC) locally advanced ductal adenocarcinoma pancreas (LA-PDAC). These represent a significant shift from previous approaches, prioritizing tumor biology over anatomical features as primary indication resection. Condensed herein, they provide practical management algorithm clinical practice. However, also highlight need to redefine LA-PDAC align with modern...
Abstract Background HIV viremia has been considered a cardiovascular disease (CVD) risk factor, but many studies have had insufficient data on potential confounders. We explored the association between and CVD after adjusting for established factors analyzed whether consideration of would improve prediction. Methods Adults from RESPOND were followed first date with available until rigorously defined CVD, loss to follow-up, death, or administrative censoring. associations 6 measures...
Abstract A decrease in brain-derived neurotrophic factor (BDNF), a neurotrophin essential for synaptic function, plasticity and neuronal survival, is evident early the progression of Alzheimer’s disease (AD), being apparent subjects with mild cognitive impairment or AD, both proBDNF mature BDNF levels are positively correlated measures. delivery is, therefore, considered great interest as potentially useful therapeutic strategy to contrast AD. Invasive administration has indeed been recently...
Currently, no data are available on the burden of morbidity and mortality in people with HIV-1 (PWH) harboring a 4-class drug-resistant (4DR) virus (nucleoside reverse transcriptase inhibitors, non-nucleoside protease integrase strand transfer inhibitors). The study aimed to assess incidence clinical events death this population. This was cohort PWH from PRESTIGIO Registry documented 4DR virus. Burden disease defined as occurrence any new event including an AIDS-defining (ADE) or...
Body awareness disorders and reactivity are mentioned across a range of clinical problems. Constitutional differences in the control bodily state thought to generate vulnerability psychological symptoms. Autonomic nervous system dysfunctions have been associated with anxiety, depression, post-traumatic stress. Though interoception may be transdiagnostic mechanism promoting improvement symptomatology, few psychometrically sound, symptom-independent, self-report measures, informed by...
The ability to store, retrieve, and extinguish memories of adverse experiences is an essential skill for animals' survival. cellular molecular factors that underlie such processes are only partially known. Using chondroitinase ABC treatment targeting chondroitin sulfate proteoglycans (CSPGs), previous studies showed the maturation extracellular matrix makes fear memory resistant deletion. Mice lacking cartilage link protein Crtl1 (Crtl1-KO mice) display normal CSPG levels but impaired...
GEPPO is a prospective observational multi-centric cohort including HIV-infected geriatric patients. We hypothesized that the may help characterize antiretroviral (ARV) prescribing criteria used in real life by Italian infectious disease (ID) physicians.This was cross-sectional study describing current ARV regimen HIV population (≥65 years). Antiretroviral strategies were categorized as follows: (i) multidrug regimens (MDRs), which comprised triple or mega ART combinations; (ii) less drug...