A5047967245- Telomeres, Telomerase, and Senescence
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Radiation Therapy and Dosimetry
- Cancer-related molecular mechanisms research
- Effects of Radiation Exposure
- Aortic Disease and Treatment Approaches
- Radiation Dose and Imaging
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- DNA Repair Mechanisms
- Advanced Radiotherapy Techniques
- Cardiac Valve Diseases and Treatments
- RNA modifications and cancer
- Circular RNAs in diseases
- Carcinogens and Genotoxicity Assessment
- Genetics, Aging, and Longevity in Model Organisms
- Atherosclerosis and Cardiovascular Diseases
- Aortic aneurysm repair treatments
- Laser-Plasma Interactions and Diagnostics
- Nuclear Physics and Applications
- Heavy Metal Exposure and Toxicity
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pulmonary Hypertension Research and Treatments
- ATP Synthase and ATPases Research
Istituto di Fisiologia Clinica
2016-2025
National Research Council
2012-2025
Neuroscience Institute
2023
National Academies of Sciences, Engineering, and Medicine
2013-2016
Institute of Molecular Bioimaging and Physiology
2016
University of Copenhagen
2016
Czech Academy of Sciences, Institute of Physiology
2011-2015
Bentham Science Publishers (China)
2013
Bentham Science Publishers (United Arab Emirates)
2013
Abstract Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, social activities, correlate with reduced risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness action mechanisms elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We...
Aiming to gain a detailed insight into the physiological mechanisms involved under extreme conditions, group of experienced ultra-marathon runners, performing mountain Tor des Géants® ultra-marathon: 330 km trail-run in Valle d'Aosta, 24000 m positive and negative elevation changes, was monitored. ROS production rate, antioxidant capacity, oxidative damage inflammation markers were assessed, adopting micro-invasive analytic techniques.Forty-six male athletes (45.04±8.75 yr, 72.6±8.4 kg,...
Telomere shortening is considered a cellular marker of health status and biological ageing. Exercise may influence the lifespan an individual by affecting telomere length (TL). However, it unclear whether different endurance exercise levels have beneficial or detrimental effects on aging. The aims study were to assess both chronic acute training TL after exceptional extreme trail race. was assessed in 20 athletes (17 males; age = 45.4 ± 9.2 years) 42 age- gender-matched sedentary controls...
Telomere shortening, chromosomal damage, and mitochondrial dysfunction are major initiators of cell aging biomarkers many diseases. However, the underlying correlations between nuclear DNA alterations remain unclear. We investigated relationship telomere length (TL) micronucleus (MN) their association with copy number (mtDNAcn) in peripheral blood mononuclear cells (PBMCs) response to 100 μM 200 hydrogen peroxide (H2O2) at 44, 72, 96 h. Significant TL shortening was observed after both doses...
High environmental pressure may impair male fertility by affecting sperm quality, but the real effect remains controversial. Herein, we assessed influence of exposure on telomere length (TL) in both leukocytes (LTL) and cells (STL). A pilot biomonitoring study was conducted 112 clinically healthy, normospermic men living various areas Campania region (South Italy) with high (n = 57, Group) or low 55, Low pressure. TL analysis quantitative time-PCR. STL not significantly correlated either age...
Arsenic-induced health effects may be associated with critically shortened telomeres. However, few data are available on the of arsenic exposure telomere length. The aim this study was to investigate chronic leukocyte length (LTL) as well contribution common polymorphisms in genes implicated metabolism (GSTT1 and GSTM1) DNA repair (hOGG1 XRCC1). A group 241 healthy subjects enrolled from four areas Italy known affected by natural or anthropogenic pollution. Urine samples were tested for...
One type of carbon nanotubes (CNTs) (MWCNT-7, from Mitsui) has been classified as probably carcinogenic to humans, however insufficient data does not warrant the same classification for other types CNTs. Experimental indicate that CNT exposure can result in oxidative stress and DNA damage cultured cells, whereas these materials appear induce low or no mutagenicity. Therefore, present study aimed investigate whether vitro airway epithelial cells (A549) multi-walled CNTs (MWCNTs) could...
Circulating cell‐free DNA (ccf‐DNA) and mtDNA (ccf‐mtDNA) have often been used as indicators of cell death tissue damage in acute chronic disorders, but little is known about changes ccf‐DNA ccf‐mtDNA concentrations following radiation exposure. The aim the study was to investigate impact low‐dose exposure on serum levels fragments (mtDNA‐79 mtDNA‐230) interventional cardiologists working high‐volume cardiac catheterization laboratory assess their possible role useful biomarkers. We enrolled...
Laser-driven electron accelerators are capable of producing high-energy bunches in shorter distances than conventional radiofrequency accelerators. To date, our knowledge the radiobiological effects cells exposed to electrons using a laser-plasma accelerator is still very limited. In this study, we compared dose-response curves for micronucleus (MN) frequency and telomere length peripheral blood lymphocytes laser-driven pulse X-ray radiations. Additionally, evaluated on cell survival vitro...
No treatment options are currently available to counteract cognitive deficits and/or delay progression towards dementia in older people with mild impairment (MCI). The 'Train the Brain' programme is a combined motor and intervention previously shown markedly improve functions MCI individuals compared non-trained controls, as assessed at end of 7-month intervention. Here, we extended previous analyses include long-term effects performed data disaggregation by gender, education age enrolled...
Aging is one of the main risk factors for cardiovascular disease, resulting in a progressive organ and cell decline. This study evaluated possible joint impact two emerging hallmarks aging, leucocyte telomere length (LTL) common mitochondrial DNA deletion (mtDNA4977), on major adverse events (MACEs) all-cause mortality patients with coronary artery disease (CAD). We studied 770 (673 males, 64.8 ± 8.3 years) known or suspected stable CAD. LTL mtDNA4977 were assessed peripheral blood using...
Vascular aging is recognized as one of the hallmarks atherosclerosis. Currently, a growing body evidence suggests that there exists mutual crosstalk between telomere dysfunction and mitochondrial dysmetabolism during process vascular senescence. This underscores importance comprehensively studying molecular mediators involved in this complex intricate connection. In pursuit goal, “VICTORIA” protocol entails prospective single-center cohort study aimed at recruiting patients undergoing...