A5029046652- Telomeres, Telomerase, and Senescence
- Mitochondrial Function and Pathology
- Antioxidant Activity and Oxidative Stress
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Imaging and Diagnostics
- Vitamin C and Antioxidants Research
- Menopause: Health Impacts and Treatments
- Estrogen and related hormone effects
- Effects of Radiation Exposure
- Cerebrovascular and Carotid Artery Diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Long-Term Effects of COVID-19
- Cardiovascular Health and Disease Prevention
- COVID-19 Clinical Research Studies
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Atherosclerosis and Cardiovascular Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Antimicrobial Resistance in Staphylococcus
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
Istituto di Fisiologia Clinica
2014-2024
University of Sannio
2024
Neuroscience Institute
2023
National Research Council
2016-2023
Università Cattolica del Sacro Cuore
2022
Ospedale di Circolo e Fondazione Macchi
1992-2021
Aziende Socio Sanitarie Territoriale dei Sette Laghi
2021
Fondazione Audiologica Varese
1992-2016
National Academies of Sciences, Engineering, and Medicine
2005-2015
Czech Academy of Sciences, Institute of Physiology
2011
Telomere shortening is considered a cellular marker of health status and biological ageing. Exercise may influence the lifespan an individual by affecting telomere length (TL). However, it unclear whether different endurance exercise levels have beneficial or detrimental effects on aging. The aims study were to assess both chronic acute training TL after exceptional extreme trail race. was assessed in 20 athletes (17 males; age = 45.4 ± 9.2 years) 42 age- gender-matched sedentary controls...
Telomere shortening, chromosomal damage, and mitochondrial dysfunction are major initiators of cell aging biomarkers many diseases. However, the underlying correlations between nuclear DNA alterations remain unclear. We investigated relationship telomere length (TL) micronucleus (MN) their association with copy number (mtDNAcn) in peripheral blood mononuclear cells (PBMCs) response to 100 μM 200 hydrogen peroxide (H2O2) at 44, 72, 96 h. Significant TL shortening was observed after both doses...
Chemoprevention, consisting of the administration natural and/or synthetic compounds, appears to be an alternative way common therapeutical approaches preventing occurrence various cancers. Cladosporols, secondary metabolites from Cladosporium tenuissimum, showed a powerful ability in controlling human colon cancer cell proliferation through peroxisome proliferator-activated receptor gamma (PPARγ)-mediated modulation gene expression. Hence, we carried out experiments verify anticancer...
Background: Magnitude and major causes of oxidative stress may be different between sexes, although limitedly addressed in clinical studies with controversial results. The present study aimed to determine whether any gender-related difference exists concerning a population 332 subjects both wide age range, without cigarette smoking habit.
High environmental pressure may impair male fertility by affecting sperm quality, but the real effect remains controversial. Herein, we assessed influence of exposure on telomere length (TL) in both leukocytes (LTL) and cells (STL). A pilot biomonitoring study was conducted 112 clinically healthy, normospermic men living various areas Campania region (South Italy) with high (n = 57, Group) or low 55, Low pressure. TL analysis quantitative time-PCR. STL not significantly correlated either age...
Arsenic-induced health effects may be associated with critically shortened telomeres. However, few data are available on the of arsenic exposure telomere length. The aim this study was to investigate chronic leukocyte length (LTL) as well contribution common polymorphisms in genes implicated metabolism (GSTT1 and GSTM1) DNA repair (hOGG1 XRCC1). A group 241 healthy subjects enrolled from four areas Italy known affected by natural or anthropogenic pollution. Urine samples were tested for...
Intestinal bacterial communities participate in gut homeostasis and are recognized as crucial bowel inflammation colorectal cancer (CRC). Fusobacterium nucleatum (Fn), a pathobiont of the oral microflora, has recently emerged CRC-associated microbe linked to disease progression, metastasis, poor clinical outcome; however, primary cellular and/or microenvironmental targets this agent remain elusive. We report here that Fn directly putative stem cells (CR-CSCs), tumor cell subset endowed with...
Circulating cell‐free DNA (ccf‐DNA) and mtDNA (ccf‐mtDNA) have often been used as indicators of cell death tissue damage in acute chronic disorders, but little is known about changes ccf‐DNA ccf‐mtDNA concentrations following radiation exposure. The aim the study was to investigate impact low‐dose exposure on serum levels fragments (mtDNA‐79 mtDNA‐230) interventional cardiologists working high‐volume cardiac catheterization laboratory assess their possible role useful biomarkers. We enrolled...
Lhermitte-Duclos disease is a rare pathologic condition consisting of dysplastic gangliocytoma the cerebellum. Its association with phacomatosis and an autosomal dominant neoplastic syndrome, Cowden's syndrome also known. Modern neuroimaging contributes to correct diagnosis pre- postoperative evaluation. Here we describe morphologic metabolic aspects as shown by conventional MRI, diffusion imaging spectroscopy in 31-year-old woman. In addition, specific neuroradiologic characteristics are...
Aging is one of the main risk factors for cardiovascular disease, resulting in a progressive organ and cell decline. This study evaluated possible joint impact two emerging hallmarks aging, leucocyte telomere length (LTL) common mitochondrial DNA deletion (mtDNA4977), on major adverse events (MACEs) all-cause mortality patients with coronary artery disease (CAD). We studied 770 (673 males, 64.8 ± 8.3 years) known or suspected stable CAD. LTL mtDNA4977 were assessed peripheral blood using...
No treatment options are currently available to counteract cognitive deficits and/or delay progression towards dementia in older people with mild impairment (MCI). The 'Train the Brain' programme is a combined motor and intervention previously shown markedly improve functions MCI individuals compared non-trained controls, as assessed at end of 7-month intervention. Here, we extended previous analyses include long-term effects performed data disaggregation by gender, education age enrolled...
Genetic predisposition has been shown to affect the severity of skin complications in breast cancer patients after radiotherapy. Limited data exist regarding use a genetic risk score (GRS) for predicting tissue radiosensitivity. We evaluated impact different single-nucleotide polymorphisms (SNPs) genes related DNA repair mechanisms and oxidative stress response combined GRS on acute adverse effects induced by radiation therapy (RT). Skin toxicity was scored according Radiation Therapy...
Background and aim. The effects of tibolone on cardiovascular risk is not yet fully understood today. We designed this study to assess the effect menopausal status treatment (2.5 mg/day for 3 months) different biomarkers in healthy women.Methods. Blood arterial pressure were measured, blood samples collected glucose, lipid profile (total cholesterol, high density lipoproteins, HDL, low triglycerides), inflammatory (C-reactive protein, Interleukin-6, IL-6, tumor necrosis factor α, TNFα)...
Background: In order to evaluate whether there is still present a very large variability in measured values and analytical performance among different free thyroid (FT) hormone immunoassays, we considered the results derived from an External Quality Assessment (EQA) scheme, named Immunocheck.
Brain- derived neurotrophic factor (BDNF) is linked to neurodegenerative diseases (e.g. Alzheimer disease and Parkinson disease) which are often characterized by olfactory impairment. A specific single nucleotide polymorphism of the BDNF gene, Val66Met, modulates intracellular trafficking activity-dependent secretion protein. The aim this study was investigate a possible association between brain- Val66Met function, well-known biomarker for neurodegeneration, in healthy young adults. total...
Environmental enrichment may slow cognitive decay possibly acting through an improvement in vascular function. Aim of the study was to assess effects a 7-month cognitive, social, and physical training program on function patients with mild impairment. In single-center, randomized, parallel-group study, 113 (age, 65-89 years) were randomized multidomain (n=55) or usual care (n=58). All participants underwent neuropsychological tests evaluation, including brachial artery flow-mediated...