A5041078416- Advanced Glycation End Products research
- Pancreatic function and diabetes
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Atherosclerosis and Cardiovascular Diseases
- Electrospun Nanofibers in Biomedical Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Tissue Engineering and Regenerative Medicine
- Acute Myocardial Infarction Research
- Inflammatory mediators and NSAID effects
- Stroke Rehabilitation and Recovery
- MicroRNA in disease regulation
- Fatty Acid Research and Health
- Cardiovascular Health and Disease Prevention
- Ultrasound and Hyperthermia Applications
- Xenotransplantation and immune response
- COVID-19 Clinical Research Studies
- Botulinum Toxin and Related Neurological Disorders
- Alcohol Consumption and Health Effects
- Acute Ischemic Stroke Management
National Research Council
2012-2025
Istituto di Fisiologia Clinica
2016-2025
Czech Academy of Sciences, Institute of Physiology
1999-2023
Istituto S.Anna Crotone
2012-2021
In-Q-Tel
2012
University of Perugia
1997-2008
Fondazione Toscana Gabriele Monasterio
2008
University of Florence
2006
University of Chieti-Pescara
2000-2005
Columbia University
2005
Background — The products of nonenzymatic glycation and oxidation proteins, the advanced end (AGEs), form under diverse circumstances such as aging, diabetes, kidney failure. Recent studies suggested that AGEs may in inflamed foci, driven by or myeloperoxidase pathway. A principal means which alter cellular properties is through interaction with their signal-transduction receptor RAGE. We tested hypothesis RAGE on endothelial cells enhances vascular activation. Methods Results AGEs, RAGE,...
Abstract Vascular cell adhesion molecule-1 (VCAM-1) is a protein expressed on the surface of activated endothelial cells and in early atherosclerosis. Because part shed circulation can be detected peripheral plasma [soluble (s)VCAM-1], we hypothesized that sVCAM-1 may circulating marker presence severity atherosclerosis humans. We selected 11 patients with essential hypertension plus vascular disease (PVD) matched them for age, gender, body mass index, smoking habits uncomplicated (UH)...
Context: The interaction of advanced glycation end products, including Nε-(carboxymethyl)lysine-protein adducts (CML) and S100A12 protein, with their cellular receptor (RAGE) is implicated in the pathogenesis diabetic vascular complications. RAGE has a circulating secretory form, soluble (sRAGE), which, by neutralizing action might exert protective role against development cardiovascular disease. Objective: objective study was to investigate whether plasma sRAGE levels are associated...
The interaction of advanced glycation end products (AGEs) with their main receptor RAGE in endothelial cells induces intracellular generation reactive oxygen species (ROS) and the expression vascular cell adhesion molecule (VCAM)-1. We investigated role distinct sources ROS, including mitochondrial electron transport chain, NAD(P)H oxidase, xanthine arachidonic acid metabolism, AGE-induced VCAM-1 expression.The induction ROS by AGEs cultured human umbilical vein was specifically blocked an...
Abstract —The antiatherogenic effect of estrogen is mediated, in part, by inhibitory effects on endothelial vascular cell adhesion molecule-1 (VCAM-1) expression. To determine the mechanism which regulates VCAM-1 expression, we compared 17β-estradiol (E 2 ) and glucocorticoid dexamethasone (Dex) lipopolysaccharide (LPS)–induced expression human cells. E decreased LPS-induced mRNA protein to a greater extent than Dex. Dex, but not , stabilized mRNA. This correlated with inhibition monocytoid...
Advanced glycation end products (AGEs) are critically involved in atherogenesis diabetes by binding to receptors for AGE (RAGEs) vascular cells, thus inducing the expression of proinflammatory mediators. In animal models, interruption AGE-RAGE interaction reduces lesion size and plaque development. Therefore, limiting RAGE might be an intriguing concept modulate disease diabetic patients. The present study investigated whether thiazolidinediones (TZDs), antidiabetic agents clinically used...
The receptor for advanced glycation end products (RAGE) is a multiligand signal transduction that can initiate and perpetuate inflammation. Its soluble isoform (sRAGE) acts as decoy RAGE ligands, thought to afford protection against With the present study, we aimed at determining whether circulating sRAGE correlated with emphysema chronic cor pulmonale in obstructive pulmonary disease (COPD). In 200 COPD patients 201 age- sex-matched controls, measured lung function by spirometry, ELISA...
Background. In Italy, 20 min of continuous, flat-line electrocardiogram are required for death declaration. Despite prolonged warm ischemia time, Italian centers reported good outcomes in controlled donation after circulatory (cDCD) liver transplantation by combining normothermic regional and end-ischemic machine perfusion (MP). The aim this study was to evaluate the safety feasibility use septuagenarian octogenarian cDCD donors with approach. Methods. All older than 70 y were evaluated...
Boron nitride nanotubes (BNNTs) are tubular nanoparticles with a structure analogous to that of carbon nanotubes, but B and N atoms completely replace the C atoms. Many favorable results indicate BNNTs as safe nanomaterials; however, important concerns have recently been raised about ultra-pure, long (~10 µm) tested on several cell types.Here, we propose additional experiments same BNNTs, shortened (~1.5 homogenization/sonication treatment allows for their dispersion in gum Arabic aqueous...
Diagnostic cardiac ultrasound are commonly assumed to pose no hazard the patient—but this is not synonymous with being biologically inert. The production of intracellular reactive oxygen species (ROS) on endothelial cells a key modulator atheroprotective (at low level) and atherogenic high levels) actions. aim study was evaluate in vitro effects ROS after exposure variable duration commercially available imaging systems. Endothelial fluorescence evaluated sham (transducer off) 5', 15' 30'...