A5085452620- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Neuroscience and Neural Engineering
- Boron and Carbon Nanomaterials Research
- Advanced Nanomaterials in Catalysis
- Advanced Sensor and Energy Harvesting Materials
- Nanoparticles: synthesis and applications
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- MXene and MAX Phase Materials
- Carbon Nanotubes in Composites
- Spaceflight effects on biology
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Cellular Mechanics and Interactions
- Molecular Communication and Nanonetworks
- Advanced biosensing and bioanalysis techniques
- Boron Compounds in Chemistry
- Nerve injury and regeneration
- Graphene research and applications
- Planarian Biology and Electrostimulation
- Photoacoustic and Ultrasonic Imaging
- Photoreceptor and optogenetics research
Piaggio (Italy)
2011-2025
Italian Institute of Technology
2016-2025
Piaggio Aerospace (Italy)
2016-2025
Interface (United States)
2019-2025
Center for Micro-BioRobotics
2015-2024
Waseda University
2008-2022
Polytechnic University of Turin
2015-2020
Scuola Superiore Sant'Anna
2006-2020
University of Pisa
2005-2006
Every year, cancer is responsible for millions of deaths worldwide and, even though much progress has been achieved in medicine, there are still many issues that must be addressed order to improve therapy. For this reason, oncological research putting a lot effort towards finding new and efficient therapies which can alleviate critical side effects caused by conventional treatments. Different technologies currently under evaluation clinical trials or have already introduced into practice....
Tetragonal barium titanate nanoparticles (BTNPs) have been exploited as nanotransducers owing to their piezoelectric properties, in order provide indirect electrical stimulation SH-SY5Y neuron-like cells. Following application of ultrasounds cells treated with BTNPs, fluorescence imaging ion dynamics revealed that the synergic is able elicit a significant cellular response terms calcium and sodium fluxes; moreover, tests appropriate blockers demonstrated voltage-gated membrane channels are...
Accumulation of reactive oxygen species in cells leads to oxidative stress, with consequent damage for cellular components and activation cell-death mechanisms. Oxidative stress is often associated age-related conditions, as well several neurodegenerative diseases. For this reason, antioxidant molecules have attracted a lot attention, especially those derived from natural sources─like polyphenols tannins. The main issue related the use antioxidants their inherent tendency be oxidized, quick...
Smart nanomaterials, thanks to their stimuli-responsive properties, represent a promising class of nanostructures for biomedical applications. Their ability undergo structural or functional changes in response specific external cues has been exploited the manipulation cellular activities as potential treatment various health disorders. Despite rather interesting properties and applications, most smart are composed inorganic materials, thus limiting translatability clinical applications due...
In this paper, we propose an absolutely innovative technique for the electrical stimulation of cells, based on piezoelectric nanoparticles. Ultrasounds are used to impart mechanical stress boron nitride nanotubes incubated with neuronal-like PC12 cells. By virtue their properties, these can polarize and convey stimuli stimulated present method exhibit neurite sprout 30% greater than control cultures after 9 days treatment.
Boron nitride nanotubes (BNNTs) have unique physical properties, which can be exploited in the biomedical field. Hence, surprising lack of reported studies on their biocompatibility and interactions with living cells, addressed by present paper deals results such an investigation based 72 h culture human neuroblastoma cell line (SH-SY5Y) presence aqueous suspension polyethyleneimine (PEI)-coated BNNTs. BNNTs conjugated fluorescent markers (quantum dots) are employed to enable tracking uptake...
Boron neutron capture therapy (BNCT) is increasingly being used in the treatment of several aggressive cancers, including cerebral glioblastoma multiforme. The main requirement for this selective targeting tumor cells by sufficient quantities (10)B atoms required their capture/irradiation with low-energy thermal neutrons. low content boron species multiforme accounts difficulty very malignant radiation modality. In present study, we have first time nitride nanotubes as carriers to overcome...
Poly(vinylidene fluoride‐trifluoroethylene, P(VDF‐TrFE)) and P(VDF‐TrFE)/barium titanate nanoparticle (BTNP) films are prepared tested as substrates for neuronal stimulation through direct piezoelectric effect. Films characterized in terms of surface, mechanical, features before vitro testing on SH‐SY5Y cells. In particular, BTNPs significantly improve properties the (4.5‐fold increased d 31 ). Both kinds support good viability differentiation. Ultrasound (US) is proven to elicit Ca 2+...
Abstract The investigation of the crossing exogenous substances through blood‐brain barrier (BBB) is object intensive research in biomedicine, and one main obstacles for reliable vitro evaluations represented by difficulties at base developing realistic models barrier, which could resemble as most accurately possible vivo environment. Here, first time, a 1:1 scale, biomimetic, biohybrid BBB model proposed. Microtubes inspired to brain capillaries were fabricated two‐photon lithography used...
In this letter, we report on the fabrication, characterization, and in vitro testing of structures suitable for cell culturing, prepared through two-photon polymerization a nanocomposite resist. More details, commercially available Ormocomp has been doped with piezoelectric barium titanate nanoparticles, bioinspired 3D resembling trabeculae sponge bone have fabricated. After an extensive preliminary demonstrated that both topographical cues these scaffolds are able to enhance differentiation...
Electrical stimulation of cells and tissues is an important approach interaction with living matter, which has been traditionally exploited in the clinical practice for a wide range pathological conditions, particular, related to excitable tissues. Standard methods are, however, often invasive, being based on electrodes wires used carry current intended site. The possibility achieve indirect electrical stimulation, by means piezoelectric materials, therefore outstanding interest all...