A5072501798- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Nuclear Structure and Function
- Hemoglobin structure and function
- Pancreatic function and diabetes
- Dementia and Cognitive Impairment Research
- Neuroscience of respiration and sleep
- Biochemical Analysis and Sensing Techniques
- Muscle Physiology and Disorders
- RNA regulation and disease
- RNA Research and Splicing
- Cerebral Palsy and Movement Disorders
- Nicotinic Acetylcholine Receptors Study
- Pharmacology and Obesity Treatment
- Immune cells in cancer
- SARS-CoV-2 and COVID-19 Research
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Skin and Cellular Biology Research
- Immune Cell Function and Interaction
- Cardiovascular Health and Disease Prevention
- Dietary Effects on Health
- Neonatal Respiratory Health Research
University of Pisa
2011-2024
Istituto di Fisiologia Clinica
2018-2023
National Research Council
2018-2022
Azienda Ospedaliera Universitaria Pisana
2010-2020
Dulbecco Telethon Institute
2010-2012
Abstract Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, social activities, correlate with reduced risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness action mechanisms elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We...
Epidemiological evidence emphasizes that excess fat mass is associated with an increased risk of severe COVID-19 disease. Nevertheless, the intricate interplay between SARS-CoV-2 and adipocytes remains poorly understood. It crucial to decipher progression both in acute phase on long-term outcomes. In this study, vitro model using human SGBS cell line (Simpson-Golabi-Behmel syndrome) was developed investigate infectivity adipocytes, effects virus exposure adipocyte function. Our results show...
Background Oxidative stress (OS) plays a major role on tissue function. Several catabolic or conditions exacerbate OS, inducing organ deterioration. Haptoglobin (Hp) is circulating acute phase protein, produced by liver and adipose tissue, has an important anti-oxidant Hp induced in pro-oxidative such as systemic inflammation obesity. The of factors that modulate oxidative inside muscle cells still poorly investigated. Results We used knockout mice (Hp-/-) to determine the this protein...
Immune tolerance to transplanted organs is impaired when the innate immune system activated in response tissue necrosis that occurs during harvesting and implantation procedures. A key molecule this pathway intracellular TLR signal adaptor known as myeloid differentiation primary gene 88 (MyD88). After transplantation, MyD88 induces DC maturation well production of inflammatory mediators, such IL-6 TNF-α. However, upstream activators function transplantation have not been identified. Here,...
Western lifestyle contributes to body weight dysregulation. Leptin down-regulates food intake by modulating the activity of neural circuits in hypothalamic arcuate nucleus (ARC), and resistance this hormone constitutes a permissive condition for obesity. Physical exercise modulates leptin sensitivity diet-induced obese rats. The role other components remains elusive. Environmentally enriched mice were used explore effects change on production/action metabolic parameters. We analyzed adult...
Abstract Leptin and Brain Derived Neurotrophic Factor (BDNF) pathways are critical players in body weight homeostasis. Noninvasive treatments like environmental stimulation able to increase response leptin induce BDNF expression the brain. Emerging evidences point antidepressant selective serotonin reuptake inhibitor Fluoxetine (FLX) as a drug with effects similar stimulation. FLX is known impact on weight, mechanisms yet be elucidated. We herein asked whether affects energy balance, system...
OBJECTIVE Haptoglobin (Hp) is upregulated in both inflammation and obesity. The low chronic inflammatory state, caused by massive adipose tissue macrophage (ATM) infiltration found obesity, adiponectin have been implicated the development of insulin resistance hepatosteatosis. aim this work was to investigate whether how Hp interferes with onset obesity-associated complications. RESEARCH DESIGN AND METHODS Hp-null (Hp−/−) wild-type (WT) mice were metabolically profiled under chow-food diet...
Berardinelli-Seip congenital lipoatrophy (BSCL) is characterized by near total fat atrophy, associated with the progressive development of metabolic complications. BSCL type 1 (BSCL1) caused mutations in AGPAT2, encoding 1-acylglycerol-3phosphate-O-acyltransferase (recently renamed lysophosphatidic acid acyltransferase beta), which catalyzes transformation phosphatidic acid, precursor glycerophospholipids and triglycerides. BSCL1 an autosomal recessive disease due to AGPAT2 pathogenic...
No treatment options are currently available to counteract cognitive deficits and/or delay progression towards dementia in older people with mild impairment (MCI). The 'Train the Brain' programme is a combined motor and intervention previously shown markedly improve functions MCI individuals compared non-trained controls, as assessed at end of 7-month intervention. Here, we extended previous analyses include long-term effects performed data disaggregation by gender, education age enrolled...
Environmental enrichment may slow cognitive decay possibly acting through an improvement in vascular function. Aim of the study was to assess effects a 7-month cognitive, social, and physical training program on function patients with mild impairment. In single-center, randomized, parallel-group study, 113 (age, 65-89 years) were randomized multidomain (n=55) or usual care (n=58). All participants underwent neuropsychological tests evaluation, including brachial artery flow-mediated...
Haptoglobin (Hp) is an inflammatory and adiposity marker, its expression during obesity being specifically induced in the white adipose tissue (WAT). We previously reported that when challenged with a high fat diet (HFD) Hp-/- mice are partially protected from onset of insulin resistance hepatosteatosis. The aim present study was to get further insights into Hp function WAT. To this end, we performed histological gene analysis WAT, both standard conditions, investigated how deficiency...
Lipodystrophy (LD) indicates a group of rare disorders, with generalized or partial loss white adipose tissue (WAT) often associated metabolic derangements. Heterogeneity/wide spectrum the disease and lack biomarkers make diagnosis difficult. MicroRNAs are important to maintain correct WAT function is source circulating miRNAs (cmiRs). from 320 family were previously detected in variably syndrome. Our aim was then investigate if LD can result altered abundance cmiRs-320. We collected samples...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)