A5022054317- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- HIV-related health complications and treatments
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Research on Leishmaniasis Studies
- HIV, Drug Use, Sexual Risk
- Pharmacological Effects and Toxicity Studies
- Viral-associated cancers and disorders
- Pharmaceutical Economics and Policy
- Mycobacterium research and diagnosis
- HIV/AIDS Impact and Responses
- COVID-19 Clinical Research Studies
- Parasites and Host Interactions
- Trypanosoma species research and implications
- Streptococcal Infections and Treatments
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Liver Disease and Transplantation
Ospedale di Sanremo
2006-2024
Ente Ospedaliero Ospedali Galliera
2013-2023
ASL Roma
2023
University of Modena and Reggio Emilia
2021
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2021
University of Milan
2016
Hôpital l'Archet
2009
Centre Hospitalier Universitaire de Nice
2009
The PRESTIGIO Registry was established in 2017 to collect clinical, virological and immunological monitoring data from people living with HIV (PLWH) documented four-class drug resistance (4DR). Key research purposes include the evaluation of residual susceptibility specific antiretrovirals validation treatment strategies this population.
Dolutegravir (DTG) plus darunavir/ritonavir (DRV/r) is a simple combination of drugs that has the best genetic barrier to HIV-1 resistance and may be fit for salvage therapy.All HIV-1-infected subjects treated with DTG DRV/r between March 2014 September 2015 in eight Italian centres were included analysis. The main metabolic data, efficacy parameters safety data routinely collected provided. This observational study aimed assess such approach. primary end-point was proportion achieving or...
Currently, no data are available on the burden of morbidity and mortality in people with HIV-1 (PWH) harboring a 4-class drug-resistant (4DR) virus (nucleoside reverse transcriptase inhibitors, non-nucleoside protease integrase strand transfer inhibitors). The study aimed to assess incidence clinical events death this population. This was cohort PWH from PRESTIGIO Registry documented 4DR virus. Burden disease defined as occurrence any new event including an AIDS-defining (ADE) or...
Cefiderocol is a siderophore cephalosporin showing activity against various carbapenem-resistant Gram-negative bacteria (CR-GNB). No data currently exist about real-world use of cefiderocol in terms types therapy (e.g., empirical or targeted, monotherapy combined regimens), indications, and patient characteristics. In this multicenter, prospective study, we aimed at describing the therapy, was administered as targeted 27.5% (55/200) 72.5% (145/200) cases, respectively. Overall, it 101/200...
Summary Background Patients with thalassaemia major depend on blood transfusions. In Italy, up to 80% of patients bear HCV antibodies due contaminated transfusions before 1990. Thalassaemia infection have high risk developing HCC . Treatment based Pegylated‐ IFN (Peg‐ ) and Ribavirin ( RBV was limited by relevant side effects. Aim To evaluate the impact Sofosbuvir/Ledipasvir SOF / LDV fixed dose combination for 12 weeks without , in Genotype 1 or 4 GT 1/4). Methods Open label,...
Barriers to access care, different diagnostic strategies and low awareness remain challenging issues in the fight against schistosomiasis.Our study aims examine management of schistosomiasis migrants attending large tertiary hospitals Italy, order call for a comprehensive approach.A retrospective review cases was carried out between January 1, 2016, December 31, 2017, five Infectious Disease Centers Italy. We included all patients diagnosed with schistosomiasis. differentiated among (i)...
To clarify whether next-generation sequencing (NGS) can be useful for resistance assessment in virologically suppressed highly treatment-experienced (HTE) individuals with MDR HIV.
Background: In recent years, Highly-Active Anti-Retroviral Therapies (HAARTs) have modified the Human Immunodeficiency Virus (HIV) life-cycle and disease is now considered chronic. Consequently, a longitudinal complex follow-up required for HIV positive patients during their lifetime. Moreover, often encounter various complications due to comorbidities, related immunodeficiency state HAARTs' side effects. Thus, are involved in multicenter clinical trials (MCTs) improve treatments discover...
In the last 20 years routine T CD4+ lymphocyte (CD4+) cell count has proved to be a key factor determine stage of HIV infection and start or discontinue prophylaxis for opportunistic infections. However, several studies recently showed that in stable patients on cART quarterly monitoring results limited (or null) clinical relevance. The research is intended investigate whether performing counts HIV-1 still recommendable provide forecast cost saving could achieved by reducing such category...
Abstract During chronic inflammatory disorders, a persistent natural killer (NK) cell derangement is observed. While increased turnover expected, little known about whether and how NK-cell homeostatic balance maintained. Here, flow cytometric analysis of peripheral blood mononuclear cells in both infectious non-infectious, reveals the presence CD34 + CD226(DNAM-1) bright CXCR4 population displaying transcriptional signatures typical common lymphocyte precursors giving rise to progenies with...
In clinical trials, a sofosbuvir/velpatasvir (SOF/VEL) pangenotypic single-tablet regimen was associated with high sustained virological response (SVR) rates at 12 weeks (SVR12) after the end of treatment, regardless genotype and fibrosis stage. No real-life data on 3 (GT3) cirrhotic patients portal hypertension are available. The aim this study to assess effectiveness SOF/VEL in GT3 cirrhotics hypertension. Patients advanced cirrhosis were treated for without ribavirin five different...
BackgroundHIV-associated immunodeficiency is related to loss of CD4+ T cells. This mechanism does not explain certain manifestations HIV disease, such as events in patients with greater than 500 cells/μL. CD8+CD28−CD127loCD39+ cells are regulatory (Treg) lymphocytes that highly concentrated within the tumor microenvironment and never analyzed circulation HIV-infected patients.ObjectivesWe sought analyze frequency Treg patients.MethodsThe circulating was correlated viral load T-cell...
Objectives: This study evaluated the virological efficacy of dolutegravir 50 mg twice daily in 190 HIV-1 failing antiretroviral-experienced patients with previous exposure to first-generation integrase strand transfer inhibitor (INSTI) over a 5 year follow-up using data from clinical practice.Patients and methods: analysis included HIV-1-infected who were 18 years age, treatment experienced, had RNA .50copies/mL, INSTI-resistant virus, started plus optimized background therapy (OBT),...
Objective. To assess the diagnostic performance of a T1-independent, T<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msup><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mrow><mml:mi>*</mml:mi></mml:mrow></mml:msup></mml:mrow></mml:math>-corrected multiecho magnetic resonance imaging (MRI) technique for quantification hepatic steatosis in cohort patients affected by chronic viral C hepatitis, using liver biopsy as gold standard. Methods. Eighty-one untreated with...
Skin and soft tissue infections (SSTIs) represent a wide range of clinical conditions characterized by considerable variety presentations severity. Their aetiology can also vary, with numerous possible causative pathogens. While other authors previously published analyses on several types SSTI restricted patients, we conducted large nationwide surveillance programme behalf the Italian Society Infectious Tropical Diseases to assess microbiological characteristics whole spectrum, from mild...
Background Dolutegravir plus darunavir provide a high genetic barrier to HIV-1 resistance and are suitable for simple salvage regimens. Methods All HIV-1-infected subjects treated with dolutegravir boosted dual therapy between March 2011 September 2015 were included in an observational cohort. Data collected at baseline weeks 4, 12, 24 48. Results We enrolled 113 subjects. After week 24, one was lost follow-up, dropped out grade 2 elevation of liver enzymes, died from illicit drug abuse...
Skin and soft tissue infections (SSTIs) represent a heterogenous group of pathological conditions involving the skin or underlying subcutaneous tissues, fascia muscle, characterised by considerable variety clinical presentations, severity possible aetiological pathogens. Although previous analyses on restricted types SSTIs population have already been published, we conducted large nationwide surveillance program behalf Italian Society Infectious Tropical Diseases to assess microbiological...
ABSTRACT The treatment of visceral leishmaniasis (VL) is poorly standardized in Italy spite the existing evidence. All consecutive patients with VL admitted at 15 Italian centers as inpatients or outpatients between January 2004 and December 2008 were retrospectively considered; outcome data 1 year after obtained for all but patient. Demographic characteristics, underlying diseases, diagnostic procedures, regimens outcomes, well side effects recorded. A confirmed diagnosis was reported 166...
Background: Dolutegravir (DTG) plus boosted darunavir (bDRV) is a compact, adherence-friendly salvage regimen with the highest genetic barrier to HIV-1 resistance.Objective: Aim of present study assess long term (96-week) safety and efficacy DTG + bDRV in multidrug-experienced infected patients, simplifying or building rescue regimens.Methods: All HIV-1-infected subjects from eleven Italian centers switched between March 2014 September 2015 were included followed for minimum 96...
The aims of this study were to assess the Health Related Quality Life (HRQoL) People Living with HIV/AIDS (PLWHA) who attend outpatient services in Genoa, Italy, and evaluate relationship between HRQoL clinical factors, primarily: CD4+ cell count, viral load HIV-Hepatitis C Virus (HCV) coinfection. A cross-sectional was performed involving a sample 943 consecutive patients. Firstly EuroQol-Five Dimensions-Three Level (EQ-5D-3L) self-reported questionnaire used HRQoL, while socio-demographic...
Objectives Lymphoproliferative disorders are often observed in HIV ‐positive patients. Combination antiretroviral treatment ( cART ) during antineoplastic chemotherapy is beneficial, but little known about the clinical outcome according to different combinations. The aim of study was address this gap current knowledge. Methods A retrospective conducted five large Italian centres for period from 1998 2015; patients diagnosed with lymphoma were included and demographic, therapeutic variables...