Otar Chokoshvili
A5009341686- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV-related health complications and treatments
- Sex work and related issues
- Escherichia coli research studies
- Hepatitis C virus research
- Viral gastroenteritis research and epidemiology
- HIV, TB, and STIs Epidemiology
- HIV/AIDS Impact and Responses
- Global Maternal and Child Health
- Viral-associated cancers and disorders
- Smoking Behavior and Cessation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hepatitis B Virus Studies
- Diabetes and associated disorders
- Cytomegalovirus and herpesvirus research
- Child and Adolescent Health
- Pneumocystis jirovecii pneumonia detection and treatment
- Liver Disease Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Tuberculosis Research and Epidemiology
- Bacteriophages and microbial interactions
- Food Security and Health in Diverse Populations
University of Copenhagen
2023
Rigshospitalet
2023
Fundació Lluita contra les Infeccions
2023
Hvidovre Hospital
2023
AIDS and Clinical Immunology Research Center
2008-2022
University College London
2020
National Center for Disease Control and Public Health
2012
In May of 2011, an enteroaggregative Escherichia coli O104:H4 strain that had acquired a Shiga toxin 2-converting phage caused large outbreak bloody diarrhea in Europe which was notable for its high prevalence hemolytic uremic syndrome cases. Several studies have described the genomic inventory and phylogenies strains associated with collection historical E. isolates using draft genome assemblies. We present complete, closed sequences isolate from 2011 (2011C-3493) two cases occurred...
Abstract Background There are conflicting data regarding baseline determinants of virological nonsuppression outcomes in persons with human immunodeficiency virus (HIV) starting antiretroviral treatment (ART). We evaluated the impact different variables RESPOND cohort. Methods included treatment-naive participants aged ≥18 who initiated 3-drug ART, 2014–2020. assessed odds suppression (VS) at weeks 48 and 96 using logistic regression. Viral blips, low-level viremia (LLV), residual (RV),...
Human immunodeficiency virus (HIV) infection leads to chronic immune activation/inflammation that can persist in virally suppressed persons on fully active antiretroviral therapy (ART) and increase risk of malignancies. The prognostic role low CD4:CD8 ratio elevated CD8 cell counts the cancer remains unclear. We investigated association hazard non-AIDS defining malignancy (NADM), AIDS-defining (ADM) most frequent group cancers ART-treated people with HIV (PWH) a CD4 viral load measurements...
Abstract Background HIV viremia has been considered a cardiovascular disease (CVD) risk factor, but many studies have had insufficient data on potential confounders. We explored the association between and CVD after adjusting for established factors analyzed whether consideration of would improve prediction. Methods Adults from RESPOND were followed first date with available until rigorously defined CVD, loss to follow-up, death, or administrative censoring. associations 6 measures...
Since 2004, the country of Georgia has provided antiretroviral therapy (ART) to all patients in need. A nationwide retrospective cohort study was conducted assess effect universal access ART on patterns mortality and causes death among HIV-infected individuals Georgia. All known adult (age ≥18 years) diagnosed from 1989 through 2012 were included. Rates determined using routinely collected data national HIV/AIDS database. Causes classified according Coding Death HIV (CoDe) protocol. Between...
Objectives Individual and public health benefits of antiretroviral therapy ( ART ) rely on successful engagement HIV ‐infected patients in care. We aimed to evaluate the care continuum E astern uropean country G eorgia. Methods The analysis included all adult (age ≥ 18 years) diagnosed eorgia from J anuary 1989 until une 2012. Data were extracted national / AIDS database as 1 O ctober following stages quantified: infected, diagnosed, linked care, retained eligible for virologically...
Abstract Background Limited data exist that compare clinical outcomes of 2-drug regimens (2DRs) and 3-drug (3DRs) in people living with human immunodeficiency virus. Methods Antiretroviral treatment–experienced individuals the International Cohort Consortium Infectious Diseases (RESPOND) who switched to a new 2DR or 3DR from 1 January 2012–1 October 2018 were included. The incidence events (AIDS, non-AIDS cancer, cardiovascular disease, end-stage liver renal death) was compared between using...
Late presentation for HIV care has important individual and population implications. The objective of this study was to explore the problem late in country Georgia. Data on adult persons newly diagnosed with Georgia between 2012 2015 were extracted from national AIDS Health Information System. presenter defined as a person CD4 cell count <350 cells/mm3 or an defining illness regardless six months after diagnosis. advanced disease <200 illness, Among 2267 adults 2012-2015, 1987 (87.6%) had...
Data on the effectiveness of second-line antiretroviral therapy (ART) in resource-limited countries Eastern Europe is limited. Objective this study was to evaluate virological outcomes ART Georgia.We conducted retrospective analysis using routinely available program data. Study included adult HIV-infected patients with confirmed HIV drug resistance, who were switched from August 2005 December 2010. Patients followed until July 1, 2011. Primary outcome achievement viral suppression....
The country of Georgia has a high burden chronic hepatitis C virus (HCV) infection, and prisoners are disproportionately affected. During 2013, novel program offering no cost screening treatment HCV infection for eligible was launched. implemented voluntary opt-in anti-HCV testing policy to all prisoners. Anti-HCV positive persons received RNA genotype testing. Transient elastography also performed on with results. Prisoners who had ≥F2 Metavir stage liver fibrosis prison sentence ≥ 6 months...
In July-August 2009, eight patients with bloody diarrhea complicated by hemolytic uremic syndrome (HUS) were admitted to hospitals in Tbilisi, Georgia.We started active surveillance two regions for and post-diarrheal HUS.Of 25 case-patients who developed HUS, including the initial 8 cases, half P15 years old, 67% female seven (28%) died.No common exposures identified.Among 20 HUS tested, Shiga toxin was detected stools of 2 (one elevated serum IgG titers several Escherichia coli serogroups,...
Background Life expectancy and quality of life people living with HIV have been dramatically improved after introducing antiretroviral therapy, the prevalence non-communicable diseases has increased. Several studies found that hyperglycemia or without type 2 diabetes was associated poor outcomes in HIV. The study’s objective to determine assess its impact on mortality. Materials methods A retrospective cohort study conducted among diagnosed 2012–2018 followed through 2020 at Infectious...
Since 2004, Georgia achieved universal access to free antiretroviral therapy (ART). A retrospective cohort study was conducted evaluate the outcomes of Georgia's ART program. The included adult patients enrolled in program from 2004 through 2009. Of 752 patients, 76% were men, 60% injection drug users (IDU), 59% had a history an AIDS-defining illness, and 53% coinfected with hepatitis C. median baseline CD4 cell count 141 cells/mm 3 . During followup, 152 (20%) died, majority deaths...
Introduction: HIV infection is the major public health, social and economic problem in Georgia. Although epidemic its nascent phase country, potential risk for development of a wide spread very high.The aim this study to evaluate effectiveness ARV treatment principles Georgia, including monitoring methods. Materials Methods: The included 985 people living with HIV/AIDS Georgia registered at Infectious Disease, AIDS Clinical Immunology Research Center since 2004. To ensure universal access...
The knowledge of HIV incidence is essential to better understand patterns transmission. We estimated over 2010–2012 in the eastern European country Georgia. Mathematical modeling using Spectrum software and assay-based recent infection testing algorithm were applied. study included 1155 patients newly diagnosed (84% total diagnoses). Of them, 231 determined be recently infected on algorithm. proportion cases did not differ between 2010, 2011 2012 (20.4% vs. 19.4% 20.2%, p = 0.94). Both...
The objective of this report was to assess Georgia's progress toward Joint United Nations Programme on HIV/AIDS 90-90-90 targets over the period between 2011 and 2015. number HIV-positive persons estimated using Spectrum software. Number diagnosed, antiretroviral therapy (ART) virally suppressed were quantified data from national AIDS health information system. By end 2015, out 7100 living with HIV, 62% 38% ART, 32% suppressed. There improvements in each stage cascade 2015: proportion...
Abstract Background Limited data exist examining the association between incident cancer and cumulative integrase inhibitor (INSTI) exposure. Methods Participants were followed from baseline (latest of local cohort enrollment or January 1, 2012) until earliest first cancer, final follow-up, December 31, 2019. Negative binomial regression was used to assess associations incidence time-updated INSTI exposure, lagged by 6 months. Results Of 29 340 individuals, 74% male, 24% antiretroviral...
Successful engagement in HIV care is required to reach UNAIDS targets of 90-90-90. We analyzed routine programmatic data quantify losses along the continuum country Georgia. Analysis was limited diagnosed persons and did not include estimated number HIV-infected persons. Cascade constructed for adult (age ≥18 years) newly Georgia 2008-2012. Data were extracted from national AIDS Health Information System as June 30, 2014. Among 1,931 patients included, median age 37 years, 72% men, 40.7% had...
Introduction: The major challenge in the HIV epidemic Georgia is a high proportion of undiagnosed people living with (estimated 48%) as well very late presentations for care, 66% presenting care CD4 count <350 and 40% <200 cells/mm 3 , 2013. objectives this study was to evaluate patient engagement continuum patients diagnosed 2013 and, within cohort, factors associated diagnosis attrition from care. Methods: Factors were analyzed through binary logistic regression. Exposure variables...
Among men who have sex with (MSM) in low- or middle-income countries, smoking and related factors been understudied. We examined correlates of status, level, importance confidence regarding quitting among 608 MSM the country Georgia recruited June-September, 2016 (493 without HIV via peer referral 3 Georgian cities; 115 National AIDS Center). Median age was 26 years, 78.6% reported current (past 30-day) alcohol use, 22.4% past-year illicit drug use. Overall, 73.8% smoking; these, 87.1%...