A5002060724- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Sex work and related issues
- Tuberculosis Research and Epidemiology
- Adolescent Sexual and Reproductive Health
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Syphilis Diagnosis and Treatment
- Reproductive tract infections research
- HIV/AIDS Impact and Responses
- Cervical Cancer and HPV Research
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Primary Care and Health Outcomes
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Global Maternal and Child Health
- Infectious Diseases and Tuberculosis
- Urinary Tract Infections Management
- COVID-19 Impact on Reproduction
State University of New York
2010-2025
SUNY Downstate Health Sciences University
2016-2025
New York University
2024
University at Albany, State University of New York
2022-2024
Island Peer Review Organization
2020-2024
Stanger Hospital
2012
Eunice Kennedy Shriver National Institute of Child Health and Human Development
1999-2011
Johns Hopkins University
2011
American College of Clinical Pharmacy
2011
Maimonides Medical Center
2003-2006
Hydroxychloroquine, with or without azithromycin, has been considered as a possible therapeutic agent for patients coronavirus disease 2019 (COVID-19). However, there are limited data on efficacy and associated adverse events.To describe the association between use of hydroxychloroquine, clinical outcomes among hospital inpatients diagnosed COVID-19.Retrospective multicenter cohort study from random sample all admitted laboratory-confirmed COVID-19 in 25 hospitals, representing 88.2% New...
ABSTRACT The development of a rapid and efficient system to identify human immunodeficiency virus type 1 (HIV-1)-infected individuals with broad potent HIV-1-specific neutralizing antibody responses is an important step toward the discovery critical neutralization targets for rational AIDS vaccine design. In this study, samples from HIV-1-infected volunteers diverse epidemiological regions were screened using pseudovirus panels composed clades A, B, C, D circulating recombinant forms (CRFs)....
Isospora belli has recently been recognized as an opportunistic protozoan pathogen in patients with the acquired immunodeficiency syndrome (AIDS). Although I. rarely causes diarrhea AIDS United States, we have documented isosporiasis 15 percent (20 of 131) such Haiti. The infection was associated chronic watery and weight loss that clinically indistinguishable from disease caused by related coccidia cryptosporidium. No demographic or laboratory data distinguished those either...
Background and Objectives: Human papillomavirus (HPV) infection of the female genital tract is most common sexually transmitted disease. Although prevalence HPV in women without detectable cervical disease has been shown to decline with increasing age, relationship sexual behavior not investigated. Goal: To identify risk factors for, associated age-dependent in, women. Study Design: The was determined a cohort 439 active inner-city between ages 18 50 years recruited Brooklyn, New York....
Objective: To determine the incidence of diabetes mellitus (DM) in a nationally representative cohort HIV-infected women and comparison group HIV-uninfected women. Design: A prospective study between October 2000 March 2006 2088 participants from Women's Interagency HIV Study who did not have evidence DM at enrollment (1524 infected 564 uninfected). Methods: Incident was defined as either having fasting glucose ≥ 1.26 g/l, reporting antidiabetic medication, or diagnosis (with subsequent...
Among women in the United States, non-Latina black South have disproportionately high rates of new HIV infections but low use pre-exposure prophylaxis (PrEP). Effective strategies to identify factors associated with PrEP eligibility could facilitate improved screening, offering, and uptake among US at risk HIV.We applied 2014 CDC criteria for at-risk HIV-negative enrolled Southern sites (Atlanta, Chapel Hill, Birmingham/Jackson, Miami) Women's Interagency Study from 2015 estimate assess...
People who inject drugs (PWID) are more likely to engage in unsafe sexual behavior placing them at high risk of acquiring HIV and other STIs. This study aims assess the prevalence predictors inconsistent condom use with casual and/or paid partners among PWID Georgia. Integrated Bio-Behavioral Surveillance Survey was conducted seven major cities Study design cross-sectional respondent-driven sampling (RDS) methodology. Data collection carried out through individual face-to-face interviews. Of...
The prevalence of untreated sexually transmitted diseases (STDs) was assessed in a cohort 372 active inner-city women (92% black, 49% US-born) with no history injection drug use who were recruited Brooklyn, New York, 1990 and 1991. presence STDs via culture, serologic analyses, medical history. Sexual drug-use histories obtained, as urine sample for toxicologic analysis. Thirty-five percent the had at least one SDI (27% Trichomonas vaginalis, 6.8% Chlamydia trachomatis, 5.2% syphilis, 2.4%...
Effective therapies to combat coronavirus 2019 (COVID-19) are urgently needed. Hydroxychloroquine (HCQ) has in vitro antiviral activity against severe acute respiratory syndrome 2 (SARS-CoV-2), but the clinical benefit of HCQ treating COVID-19 is unclear. Randomized controlled trials needed determine safety and efficacy for treatment hospitalized patients with COVID-19.
Abstract The membrane-proximal external region (MPER) of HIV-1 envelope glycoprotein (Env) can be targeted by neutralizing antibodies exceptional breadth. MPER usually have long, hydrophobic CDRH3s, lack activity as inferred germline precursors, are often from the minor IgG3 subclass, and some polyreactive, such 4E10. Here we describe an broadly antibody major IgG1 PGZL1, which shares V/D-region genes with 4E10, has a shorter CDRH3, is less polyreactive. A recombinant sublineage variant...
BACKGROUND. Recently there has been a rise in genital ulcer disease (GUD) urban minority heterosexuals the United States. The impact of these increased GUD rates on HIV transmission patterns this population is unknown. METHODS. Sexually transmitted (STD) diagnoses were correlated with antibody status and risk factor history 194 patients who consented to testing at an STD clinic central Brooklyn. RESULTS. Of 36 HIV-positive patients, 23 (64%) denied factors other than heterosexual contact...
HIV infection leads to activation of coagulation, which may increase the risk for atherosclerosis and venous thromboembolic disease. We hypothesized that replication increases coagulation potentially through alterations in extrinsic pathway factors.Extrinsic factors were measured among a subset participants from Strategies Management Anti-Retroviral Therapy (SMART) trial. Thrombin generation was estimated using validated computational modeling based on factor composition. characterized...
Efavirenz exhibits marked interindividual variability in plasma levels and toxicities. Prior pharmacogenetic studies usually measure exposure via single levels, examine limited numbers of polymorphisms, rarely model multiple contributors. We analyzed numerous genetic nongenetic factors impacting short-term long-term a large heterogeneous population human immunodeficiency virus (HIV)-infected women.We performed 24-hour intensive pharmacokinetic 111 women receiving efavirenz under actual-use...
The relationship of C-reactive protein (CRP) to mortality was assessed in 209 HIV-1–infected women after adjusting for age, body mass index (BMI), serum albumin, CD4 cell lymphocyte count, and HIV-1 RNA. During the follow-up period up 5 years (median = 45 months) there were 49 deaths. CRP at study enrollment measured using a low sensitivity assay. levels only weakly correlated (Pearson correlation coefficient r < .2) with other predictors mortality. powerful predictor (p .01) BMI,...
Evidence suggesting an increased risk of cardiovascular disease in HIV-infected individuals has heightened the need to understand relation HIV infection, antiretroviral therapy use, and non-HIV-related factors with insulin resistance (IR).Prospective study 1614 604 HIV-uninfected participants from Women's Interagency Study between October 2000 March 2007. Homeostasis model assessment (HOMA)-estimated IR at 11,019 semiannual visits.HIV-infected women reporting highly active (HAART) had higher...
Health care workers (HCWs) are at increased risk of being infected with blood-borne pathogens. To evaluate occupational exposure to viruses and determine the prevalence human immunodeficiency virus (HIV), hepatitis B (HBV) C (HCV) among HCWs in Georgia. The sample included from seven medical institutions five cities A self-administered questionnaire was used collect information on demographic, personal factors for viruses. After obtaining informed consent, blood drawn study participants a...
The purpose of our study was to assess quality life (QoL) among Georgian HIV-infected individuals and examine factors associated with QoL. Our cross-sectional sample consisted 201 adult outpatients recruited at the National AIDS Center in Tbilisi, Georgia. WHOQOL-HIV-BREF used measure Data about other variables interest were obtained from medical records. Modified Poisson regression robust variance estimates performed create a predictive model that influenced results showed following as...
Background: To clarify the role of heterosexual transmission hepatitis C virus (HCV) and to identify associated risk factors. Goal: compare factors with infection among women HCV, HIV-1, B (HBV). Study Design: A cross-sectional study prevalence HBV in a sample 599 sexually active, nontransfused, inner-city no evidence intravenous drug use. Results: The HCV was 1.6%, compared 2.0% for HIV-1 18.8% HBV; 75% infected were also or (P< 0.001). Women engaging very high-risk sexual behavior 14.2...
To investigate the effect of human immunodeficiency virus (HIV) infection on vaginal yeast colonization and symptomatic vulvovaginitis to explore effects immune compromise these conditions in HIV-positive women.Between September 1991 May 1993, 223 women without AIDS-defining were enrolled for prospective follow-up compared with 289 HIV-negative a concurrent study. Standardized gynecologic assessment was carried out.Cultures from 81 (36%) 72 (25%) positive any yeast. The most commonly...
Background: Total lymphocyte count (TLC) and hemoglobin level have been suggested as useful inexpensive parameters to indicate need for HAART in settings which CD4+ cell counts are unavailable. If delayed-type hypersensitivity (DTH) response predicts clinical persons using highly active antiretroviral therapy (HAART), it may also prove resource-poor settings. Objective: To examine whether TLC, hemoglobin, DTH observed prior initiation of predict post-HAART response. Design: Prospective...
Regardless of the nontreponemal test used for screening and diagnosis syphilis, biological false-positive results (BFPs) are documented in 1%–2% all cases. An association between BFPs human immunodeficiency virus (HIV) infection men has been suggested. We conducted a cohort study to determine whether similar HIV seropositivity exists women. Among 156 HIV-seropositive women, 9 (5.8%) had BFP syphilis. 633 HIV-seronegative only 1 (0.2%) BFP. When 25 patients 55 with reactive rapid plasma...
Design and methodsData from two cross-sectional surveys of injecting drug users (IDUs) recruited a syringe exchange program (N = 162, Study 1) or using respondent driven sampling 350, 2). Behavioral were administered; serum samples collected for HIV testing. Subjects categorized into new injectors (injecting ≤ 3 years) long-term > years).