A5037658682- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- Vagus Nerve Stimulation Research
- SARS-CoV-2 detection and testing
- Cardiac electrophysiology and arrhythmias
- Parasites and Host Interactions
- Respiratory Support and Mechanisms
- Parasitic Diseases Research and Treatment
- Immunotherapy and Immune Responses
- Neuroscience of respiration and sleep
- Pneumonia and Respiratory Infections
- Muscle and Compartmental Disorders
- Antifungal resistance and susceptibility
- Acute Kidney Injury Research
- Hepatitis B Virus Studies
- COVID-19 Digital Contact Tracing
- Nitric Oxide and Endothelin Effects
- Bacillus and Francisella bacterial research
- Data-Driven Disease Surveillance
- MicroRNA in disease regulation
- Ethics in Clinical Research
Vilnius University
2012-2024
Vilnius University Hospital Santariskiu Klinikos
2020-2022
Background and objective: According to the World Health Organization (WHO), more than 100 million people have already recovered from SARS-CoV-2 infection. Therefore, it is imperative understand possible outcomes of COVID-19. The aim our study was evaluate pulmonary function, exercise capacity, residual radiological changes, health-related quality life (HRQoL) at follow-up in a cohort pneumonia survivors. Materials Methods: Patients with infection radiologically confirmed lung injury, no...
The World Health Organization (WHO)'s Research and Development (R&D) Blueprint for Action to Prevent Epidemics, a plan of action, highlighted several infectious diseases as crucial targets prevention. These infections were selected based on thorough assessment factors such transmissibility, infectivity, severity, evolutionary potential. In line with this blueprint, the VACCELERATE Site Network approached disease experts rank listed in WHO R&D according their perceived risk triggering...
Background and Objectives: Kidney transplant recipients are at risk of developing more severe forms COVID-19 infection. The aim this study was to compare the clinical course infection among kidney patients a control group. Materials Methods: We examined 150 hospitalized with Patients were divided into (kidney recipients, n = 53) (without history transplantation, 97) groups. Demographics, characteristics, treatment data, outcomes assessed. Results: median patient age 56.0 (46.0–64.0) years,...
Background The COVID-19 infection had spread worldwide causing many deaths. Mortality rates and patients’ characteristics varied within between countries, making it important to understand the peculiarities of different populations. aim this study was identify main predictors associated with in-hospital mortality due in Vilnius, Lithuania. Materials methods This a retrospective observational cohort conducted at Vilnius University Hospital Santaros Clinics, included SARS-CoV-2 positive...
We present an extremely rare manifestation of dirofilariasis in the pleural cavity. This is first human pulmonary reported Lithuania; according to our knowledge, only two other patients were documented with this pathology world.
Background and Objectives: Kidneys are one of the main targets for SARS-CoV-2. Early recognition precautionary management essential in COVID-19 patients due to multiple origins acute kidney injury complexity chronic disease management. The aims this research were investigate association between infection renal a regional hospital. Materials Methods: data 601 from Vilnius university hospital 1 January 2020 31 March 2021 collected cross-sectional study. Demographic (gender, age), clinical...
Background/Aim: Severe pulmonary influenza A virus (IAV) infection causes lung inflammation and expression of inducible nitric oxide synthase (iNOS), leading to overproduction (NO). We studied whether zanamivir reduces through inhibition NO production in mice. Materials Methods: treated IAV-infected mice daily with intranasal zanamivir. Controls were infected either placebo-treated or untreated, not placebo-treated. Mice weighed daily. After euthanasia on day 3, lungs excised bronchoalveolar...
Background and Objective: Respiratory assistance tactic that is best for COVID-19-associated acute hypoxemic respiratory failure (AHRF) individuals has yet to be determined. Patients with AHRF may benefit from the use of a high-flow nasal cannula (HFNC) non-invasive ventilation (NIV). The goals this prospective observational research were estimate predictive factors HFNC NIV in COVID-19-related subjects. Materials Methods: enlisted participation 124 patients. A stepwise treatment approach...
To assess cardiac safety in COVID-19 patients treated with the combination of Hydroxychloroquine and Azithromycin using arrhythmia risk management plan.We retrospectively examined treatment setting pre-defined plan. The data was analyzed R statistical package version 4.0.0. A two-tailed p-value<0.05 considered significant. 81 were included from March 23rd to May 10th 2020. median age 59 years, 58.0% female. majority study population (82.7%) had comorbidities, 98.8% radiological signs...
A case-control study was conducted to assess seasonal influenza vaccine effectiveness (SIVE) during the 2015-2016 season.A performed in three departments Lithuania between 1 December 2015 and May 2016. Data on demographic clinical characteristics including vaccination status were collected from patients recommended receive vaccine. Influenza virus infection confirmed by multiplex reverse transcription polymerase chain reaction (RT-PCR) .Ninety-one (56.4%) of 163 included subjects ≥65 years...
We assessed the viability of self-sampled gargle water direct RT-LAMP (LAMP) for detecting SARS-CoV-2 infections by estimating its sensitivity with respect to gold standard indirect RT-PCR paired oro-nasopharyngeal swab samples. also impact symptom onset test time (STT)-i.e., days at sampling, on LAMP. In addition, we appraised self-sampling versus comparing results. 202 and samples were collected from hospital patients COVID-19 associated symptoms. LAMP, performed all samples, was LAMP...
Abstract The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 instigated the most serious global health crisis. Clinical presentation COVID-19 frequently includes neurological and neuropsychiatric symptoms. However, it is presently unknown whether to which extent pathological impairment blood-brain barrier (BBB) contributes development neuropathology during progression. In present study, we used human induced pluripotent stem cells-derived brain...
<title>Abstract</title> <bold>Background:</bold> We present an extremely rare manifestation of dirofilariasis in the pleural cavity. This is first human pulmonary reported Lithuania; according to our knowledge, only two other patients were documented with this pathology world. <bold>Case presentation:</bold> A 72-year-old woman was admitted hospital complaining dyspnea, left-side chest pain, and a dry cough. She retiree living alone countryside without domestic pets (sometimes stray dogs...
Influenza continues to be a significant threat global public health. Even annual vaccination fails prevent complicated illness and death. The findings in various studies suggest that severe disease is attributed pulmonary complications – primary viral secondary bacterial pneumonia. A number of investigations on influenza virus infection the mouse model demonstrate overproduction free radicals, including nitric oxide (NO), contributes development pneumonia during infection. role NO mice...
Background and Objectives: Severe critical COVID-19 pneumonia can lead to long-term complications, especially affecting pulmonary function immune health. However, the extent progression of these complications over time are not well understood. This study aimed assess lung function, radiological changes, some parameters in survivors severe up 12 months after hospital discharge. Materials Methods: prospective observational cohort followed 85 adult patients who were hospitalized with or at a...
Background Comparison of clinical value RT-qPCR-based SARS-CoV-2 tests performed on saliva samples (SSs) and nasopharyngeal swab (NPSs) for prediction the COVID-19 disease severity.Methods Three paired SSs NPSs collected every 3 days from 100 hospitalised patients during 2020 Jul-2021 Jan were tested by RT-qPCR original virus compared to 150 healthy controls. Cases divided into mild+moderate (Cohort I, N = 47) severe II, 53) cohorts compared.Results was detected in 65% (91/140) vs. 53%...
Abstract Background A pre-existing, well-established European influenza surveillance network known as I-MOVE enabled the rapid implementation of a multi-country COVID-19 hospital for hospitalized cases in early 2020. This included 257 hospitals 11 sites across nine countries. We aimed to identify whether objectives were relevant public health actions, system met its objectives, where and how shortcomings could be improved, was sustainable. Methods identified six key attributes (meeting...
Abstract Background: Hydroxychloroquine and Azithromycin use is associated with QT interval prolongation arrhythmias. Despite ongoing multiple clinical trials for treatment of COVID19 infection, no definite cardiac safety protocols were proposed. The aim our study was to assess in COVID-19 patients treated the combination using close monitoring arrhythmia risk management plan. Methods results: We retrospectively examined setting pre-defined 81 included from March 23rd May 10th 2020. median...
We present a case of tularemia complicated by rhabdomyolysis in 43-year-old male who presented with fever, swelling, and pain the right groin history week-old tick bite. Empirical parenteral amoxicillin/clavulanic acid treatment was initiated. Suspecting tularemia, gentamycin added. Later, patient started to complain muscle pain, weakness, difficulties breathing walking. Heightened levels creatine kinase myoglobin concentration (42,670 IU/L >12,000 μg/L, respectively) were found. Due...
Background: Continuous monitoring of seasonal influenza vaccine effectiveness (SIVE) is needed due to the changing nature viruses and it supports decision on annual update composition. Age-specific SIVE was evaluated against different subtypes in hospitalized population Lithuania during four seasons. Methods: A test-negative case-control study design used. its 95% confidence intervals (95% CI) were calculated as (1 – odds ratio (OR)) × 100%. Results: Adjusted 18–64-year-old individuals A,...
Background and Objectives: Chronic hepatitis C virus infection affects about 71 million people worldwide. It is one of the most common chronic liver conditions associated with an increased risk developing cirrhosis cancer. The aim this study was to evaluate changes in fibrosis hepatocellular carcinoma after direct-acting antiviral drug therapy, assess factors, linked these outcomes. Materials Methods: 70 patients were evaluated for factors de novo cancer ≥ 20% decrease ultrasound transient...
Abstract Background Influenza is a contagious viral airborne disease that adds to the clinical and economic burden on healthcare system. It could be prevented substantially by seasonal influenza vaccination. Seasonal vaccine effectiveness (SIVE) varies lot should therefore monitored. This report aims update age-stratified SIVE estimates among patients hospitalized due severe acute respiratory infection (SARI) during 2019–2020 season. Methods We performed test-negative case-control study...