A5017470628- Hearing, Cochlea, Tinnitus, Genetics
- COVID-19 and healthcare impacts
- Vestibular and auditory disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Ear Surgery and Otitis Media
- COVID-19 Clinical Research Studies
- Trauma and Emergency Care Studies
- Hearing Loss and Rehabilitation
- Noise Effects and Management
- Global Cancer Incidence and Screening
- Long-Term Effects of COVID-19
- Ultrasound in Clinical Applications
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Sepsis Diagnosis and Treatment
- Otolaryngology and Infectious Diseases
- Emergency and Acute Care Studies
- Vitamin D Research Studies
- Radiation Dose and Imaging
- Oropharyngeal Anatomy and Pathologies
- Systemic Lupus Erythematosus Research
- Body Contouring and Surgery
- Vascular Anomalies and Treatments
- Global Health and Surgery
- Simulation-Based Education in Healthcare
Centre Hospitalier Universitaire d'Angers
2020-2024
Inserm
1997-2024
Centre National de la Recherche Scientifique
1997-2024
Université d'Angers
2019-2024
Keele University
2024
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2022
University of Birmingham
2020-2021
Institut de Virologie
2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Background Vitamin D supplementation has been proposed as a treatment for Coronavirus Disease 2019 (COVID-19) based on experimental data and from small uncontrolled observational studies. The COvid19 VITamin d TRIAL (COVIT-TRIAL) study was conducted to test whether single oral high dose of cholecalciferol (vitamin D3) administered within 72 hours after the diagnosis COVID-19 improves, compared standard-dose cholecalciferol, 14-day overall survival among at-risk older adults infected with...
Abstract Background With the lack of effective therapy, chemoprevention, and vaccination against SARS-CoV-2, focusing on immediate repurposing existing drugs gives hope curbing COVID-19 pandemic. A recent unbiased genomics-guided tracing SARS-CoV-2 targets in human cells identified vitamin D among three top-scoring molecules manifesting potential infection mitigation patterns. Growing pre-clinical epidemiological observational data support this assumption. We hypothesized that...
•A reduction of the number cancer patients attending centers was observed in France from January to July 2020.•This only for newly diagnosed patients.•The new diagnosis more pronounced women, breast cancer, and prostate nonmetastatic cancer.•No compensation last months 2020. The magnitude delays may be larger within same country.•An estimation excess death resulting these is presented. BackgroundThe impact first coronavirus disease 2019 (COVID-19) wave on patient management measured...
<h3>BACKGROUND</h3> Inhaled corticosteroids are known to be beneficial for patients with asthma, but their role in treating stable chronic obstructive pulmonary disease (COPD) remains controversial. A study was undertaken determine whether inhaled of functional benefit who did not show improvement a trial oral corticosteroids. <h3>METHODS</h3> In phase I COPD were given two week course placebo followed by weeks prednisone 40 mg per day single blind manner distinguish between responders and...
Significance Presbycusis, or age-related hearing loss, is a major public health issue and the principal potentially modifiable risk factor for dementia. It caused by environmental factors largely uncharacterized genetic factors. We compared DNA sequences across genomic coding regions between familial sporadic cases of severe presbycusis controls with normal hearing. The frequency ultrarare predicted pathogenic variants in genes known to cause dominant early-onset forms deafness was...
To determine whether hydroxychloroquine decreases the risk of adverse outcome in patients with mild to moderate coronavirus disease 2019 (COVID-19) at high worsening.We conducted a multicentre randomized double-blind placebo-controlled trial evaluating COVID-19 least one following factors for worsening: need supplemental oxygen, age ≥75 years, between 60 and 74 years presence co-morbidity. Severely ill requiring oxygen therapy >3 L/min or intensive care were excluded. Eligible 1:1 ratio...
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This paper argues that professionals who make boundary-related decisions should be guided by relationship-based practice. In our roles as service users and professionals, drawing from lived experiences of professional relationships, we argue need to move away distance-based includes understanding the boundary stories narratives exist for all us – including people support, other well organisations systems within which work. When are dealing with issues, centre relationship-building skills...
Pneumocystis cariniiis an opportunistic pathogen that causes pneumonia in immunocompromised patients. To investigate the genetic diversity of P. carinii populations, multilocus enzyme electrophoresis was used to analyze five systems(malate dehydrogenase, glucose phosphate isomerase, leucine aminopeptidase, malic enzyme, and 6-phosphogluconate dehydrogenase).Only different associations (zymodemes) were recorded for 70 isolates studied. While only one combination found mice rabbits, three...
Choroidal neovascularization (CNV) is a rare but severe complication in Best disease and autosomal recessive bestrophinopathy. However, the visualization of neovascular membrane difficult on fluorescein angiography (FA) indocyanine green (ICGA) because dye leakage due to accumulation material. The authors' study reports case series pediatric where optical coherence tomography (OCTA) contributed diagnosis CNV prompt treatment. Five eyes three patients were included (two one bestrophinopathy)....
Abstract Background The efficacy of hydroxychloroquine in coronavirus disease 2019 (COVID-19) remains controversial. Methods We conducted a multicentre randomized double-blind placebo-controlled trial evaluating COVID-19 patients with at least one the following risk factors for worsening: age ≥75 years, between 60 and 74 presence comorbidity, or need supplemental oxygen (≤3 L/min). Eligible were 1:1 ratio to receive either 800mg on Day 0 followed by 400mg per day 8 days placebo. primary...
To evaluate the impact of a bootcamp for new residents in surgery, terms both knowledge and skills improvement psychological support. Prospective inclusion all 59 surgery from 2018 to 2020. Analysis their perception training comparison control groups (n = 9, including who could not attend bootcamp) with respect results evaluations surgical knowledge. A two-day is organized every year October since 2013 at All'Sims simulation center (University Hospital, Angers, France) just before beginning...
Hearing impairment (HI) is a prevalent neurosensory condition globally, impacting 5% of the population, with over 50% congenital cases attributed to genetic etiologies. In Tunisia, HI underdiagnosis prevails, primarily due limited access comprehensive clinical tools, particularly for syndromic deafness (SD), characterized by and heterogeneity. This study aimed uncover SD spectrum through 14-year investigation Tunisian cohort encompassing 700 patients from four referral centers (2007–2021)....
Abstract Introduction Evaluating skills requires developing relevant grading tools that could potentially be used for self-assessments. The goal of our study was to assess the relevance a self-assessment (SA) grid skin suture exercise as compared an evaluation carried out at same time by expert (EE), while also identifying any factors likely influence it. Materials and methods Between 2018 2022, assessment during sessions with first-year trainee surgeons. students were given fill time....
The decline of speech intelligibility in presbycusis can be regarded as resulting from the combined contribution two main groups factors: (1) audibility-related factors and (2) age-related factors. In particular, there is now an abundant scientific literature on crucial role suprathreshold auditory abilities cognitive functions, which have been found to with age even absence audiometric hearing loss. However, researchers investigating direct effect aging deal methodological issue that...
Abstract Objectives This study aimed to investigate predictive factors for revision surgery in otosclerosis. Methods was a retrospective, multicentre four tertiary centres. The primary objective that were of the need stapes surgery. Results ‘revision’ group included 145 patients, and ‘control’ 143 patients. identified statistically significant surgery: younger age, active smoking status, dyslipidaemia high blood pressure. There no difference between two groups terms surgical technique or...