A5015980808- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Facial Nerve Paralysis Treatment and Research
- Ear Surgery and Otitis Media
- Vestibular and auditory disorders
- Neurofibromatosis and Schwannoma Cases
- Ear and Head Tumors
- Ophthalmology and Eye Disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Tracheal and airway disorders
- Sinusitis and nasal conditions
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Glioma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Hearing Loss and Rehabilitation
- Teratomas and Epidermoid Cysts
- Cerebrospinal fluid and hydrocephalus
- Salivary Gland Tumors Diagnosis and Treatment
- Brain Metastases and Treatment
- Cerebral Venous Sinus Thrombosis
- Craniofacial Disorders and Treatments
- Infectious Diseases and Tuberculosis
- Peripheral Nerve Disorders
- Bone Tumor Diagnosis and Treatments
Université de Bordeaux
2008-2024
Université de Montpellier
2024
Hôpital Gui de Chauliac
2024
Hôpital Pellegrin
2011-2020
Centre Hospitalier Universitaire de Bordeaux
2009-2020
Institut Gustave Roussy
2020
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2020
Bordeaux Population Health
2012-2016
Hôpital Edouard Herriot
2015
Université Claude Bernard Lyon 1
2015
Germline mutations in SDHx genes cause hereditary paraganglioma.The aim of the study was to assess indications for succinate dehydrogenase (SDH) genetic testing a prospective study.A total 445 patients with head and neck and/or thoracic-abdominal or pelvic paragangliomas were recruited over 5 yr 20 referral centers. In addition classical direct sequencing SDHB, SDHC, SDHD genes, two methods detecting large genomic deletions duplications used, quantitative multiplex PCR short fluorescent...
The aim of the study was to evaluate incidence short- and intermediate-term postoperative complications after vestibular schwannoma surgery.Retrospective review in a tertiary referral center.In 400 patients who underwent surgical removal from 1984 2000,symptoms, preoperative evaluation, surgery, were analyzed using standardized grading systems.One hundred ninety-four men 206 women had an operation. Mean age 53.9 years (age range, 11-78 y). Tumor size according Koos stage 1 39 cases, 2 122 3...
Abstract Context Pheochromocytomas and paragangliomas (PPGLs) are characterized by a strong genetic component, with up to 40% of patients carrying germline mutation in PPGL susceptibility gene. International guidelines recommend that screening be proposed all PPGL. Objective Our objective was evaluate how positive test impacts the management outcome SDHx or VHL-related Design We performed multicentric retrospective study involving 221 propositi an SDHB, SDHD, SDHC, VHL mutation. Patients...
OBJECTIVE The goal of this study was to review decision factors and overall results regarding surgical nonsurgical management post‐traumatic facial nerve paralysis (FP). STUDY DESIGN A retrospective literature were performed. METHODS Between 1984 1990, 115 cases FP handled. Patients evaluated through clinical, audiologic, radiologic, electromyogram assessment. Depending on examination results, patients treated either medically or surgically total decompression. RESULTS Forty‐nine the 50...
Objectives: To define germs involved, clinical presentation, treatment regimen, and prognostic factors in necrotizing external otitis. Patients Methods: Retrospective study reviewing a series of 46 patients treated during 10 years tertiary care center. Diagnosis was confirmed by using otomicroscopy, computed tomographic and/or magnetic resonance imaging scan bone scintigraphy (Te 99 Ga 26 scan). were provided ceftazidime ciprofloxacin intravenously monitored Ga-67 scan. The following...
The aim of this investigation was to determine if there is any association between the size canal dehiscences and symptoms signs patients presenting with superior semicircular dehiscence syndrome.Prospective multicenter study.Tertiary referral center.Twenty-seven patients, 14 females 13 males, aged 25 83 years, coming from Switzerland, France, Belgium, or Italy, diagnosed by high-resolution computed tomographic scans temporal bone.Audiologic tests, a battery vestibular tests (Tullio...
To determine factors related to high levels of speech recognition in patients with the auditory brainstem implant (ABI).Retrospective case review.International multicenter data from hospitals and tertiary referral facilities.Patients neurofibromatosis type 2 (NF2) bilateral vestibular schwannomas.ABIs were placed after removal schwannomas.Demographic surgical collected 26 ABIs who achieved scores better than 30% correct identification sentences presented quiet listening conditions without...
To describe the presentation of intralabyrinthine schwannomas (ILSs).Retrospective multicenter study involving 12 European skull base surgery tertiary referral centers.One hundred ten patients with diagnosis ILS, either labyrinth confined or extending into internal auditory meatus for less than 50% their volume.Data collected were age, sex, nature and timing presenting symptoms, hearing (according to AAO-HNS grading system), results vestibular tests (caloric cervical vestibular-evoked...
Significance Presbycusis, or age-related hearing loss, is a major public health issue and the principal potentially modifiable risk factor for dementia. It caused by environmental factors largely uncharacterized genetic factors. We compared DNA sequences across genomic coding regions between familial sporadic cases of severe presbycusis controls with normal hearing. The frequency ultrarare predicted pathogenic variants in genes known to cause dominant early-onset forms deafness was...
Object. The goal of this study was to assess the clinical results hypoglossal-facial nerve attachment (HFA), which primarily performed in patients following excision tumors cerebellopontine angle. In six a new side-to-end procedure used. Methods. authors have retrospective 33 who underwent HFA, including 24 classic end-to-end, three May, and procedures. For latter procedure, hemihypoglossal—facial by rerouting intratemporal facial nerve; avoided jump-cable graft used May's technique. is...
The incidence of CNS tumors is subject to geographical and temporal variations which are poorly understood. these was studied in Gironde, a department southwestern France with 1,058,911 inhabitants older than 16 years. We recorded any malignant or benign central nervous system (CNS) tumor diagnosed between May 1999 April 2001 adults living Gironde. Three hundred twenty-nine were during the study period. therefore 15.5 per 100,000. Overall, according sex 14.7 for males 16.2 100,000 females....
To assess the qualitative and quantitative aspects of multifrequency tympanograms in patients with Ménière's disease.Prospective study adults.University medical center.Forty disease outside episodes 24 normal-hearing subjects no otologic history.Resonance frequency sweep admittance, conductance, susceptance at 2 kHz resonance were performed each ear.A assessment was to find reproducible comparable (Student's t test) as a prerequisite for assessment. Four measurement criteria compared between...
For many years, the retrolabyrinthine approach has been limited to functional surgery of cerebellopontine angle (CPA). As a result increased surgical exposure, particularly opening internal auditory meatus (IAM), widened technique permits tumor excision from both CPA and IAM, regardless histological nature tumor. The authors have treated 60 acoustic neuromas varying sizes via this (6% intrameatal tumors; 30% > 25 mm in diameter). postoperative mortality rate was 0%. risk fistula formation...