A5058168728- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Vasculitis and related conditions
- Dermatological and Skeletal Disorders
- Prion Diseases and Protein Misfolding
- Genomics and Chromatin Dynamics
- Neurological diseases and metabolism
- Spondyloarthritis Studies and Treatments
- Otitis Media and Relapsing Polychondritis
- Cancer-related gene regulation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ocular Oncology and Treatments
- Prostate Cancer Treatment and Research
- Protein Tyrosine Phosphatases
- Cytokine Signaling Pathways and Interactions
- Infectious Diseases and Tuberculosis
- Cancer-related molecular mechanisms research
- Nephrotoxicity and Medicinal Plants
- Trace Elements in Health
- Histone Deacetylase Inhibitors Research
- IgG4-Related and Inflammatory Diseases
- Vascular Malformations Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Pituitary Gland Disorders and Treatments
Centre Hospitalier Universitaire de Clermont-Ferrand
2011-2022
Clermont Université
2015-2020
Université Clermont Auvergne
2017-2019
Centre Jean Perrin
2017
Hôpital Dupuytren
2016
Laboratoire d'Aérologie
2016
Target (United States)
2015
Inserm
2000
Université Claude Bernard Lyon 1
2000
Sorbonne Université
2000
H3K27me3 histone marks shape the inhibition of gene transcription. In prostate cancer, deregulation might play a role in tumor progression.We investigated genome-wide methylation profile using chromatin immunoprecipitation (ChIP) and 2X400K promoter microarrays to identify differentially-enriched regions biopsy samples from cancer patients. were assessed 34 tumors: 11 with Gleason score > 7 (GS 7), 10 ≤ 13 morphologically normal samples.Here, profiling identified an average 386...
Glioblastomas multiforme (GBMs) grow rapidly and are highly resistant to treatment compared with other glioma types grades. Consequently, it is of major interest identify markers aggressiveness in these tumors that could represent new therapeutic targets. Interleukin (IL)-6 frequently produced gliomas and, given its manifold properties, be considered as a candidate marker. Expression IL-6 may involved cell growth, resistance chemotherapy radiotherapy (via an antiapoptotic pathway),...
Significance Presbycusis, or age-related hearing loss, is a major public health issue and the principal potentially modifiable risk factor for dementia. It caused by environmental factors largely uncharacterized genetic factors. We compared DNA sequences across genomic coding regions between familial sporadic cases of severe presbycusis controls with normal hearing. The frequency ultrarare predicted pathogenic variants in genes known to cause dominant early-onset forms deafness was...
It is well established that genetic and epigenetic alterations are common events in prostate cancer, which may lead to aberrant expression of critical genes. The importance mechanisms cancer carcinogenesis increasingly evident. In this study, the focus will be on histone modifications primary objectives map H3K27me3 marks quantify RAR beta 2, ER alpha, SRC3, RGMA, PGR, EZH2 gene expressions tissues compared normal tissues. addition, a data analysis was made connection with...
Objectives: To determine the contribution of methionine/valine (Met/Val) polymorphism at codon 129 prion protein (PrP) gene in neuropathologic pattern and mechanisms lesion development sporadic Creutzfeldt–Jakob disease. Background: disease is a transmissible spongiform encephalopathy characterized by conformational change PrP variety deposits brain, some which aggregate into amyloid plaques. Methods: The authors semiquantitatively assessed lesions performed immunolabeling 70 patients (39...
In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, polycomb repressive marks, contribute to gene deregulation in cancer. To dissect the relative contribution methylation–dependent and –independent mechanisms alterations at CpG island/promoter-associated genes cancer, we studied 70 samples adult glioma, a widespread type brain tumor, classified according...
Discriminating Creutzfeldt-Jakob disease (CJD) from dementia with Lewy bodies (DLB) may be clinically difficult to achieve. The authors describe 10 patients DLB initially referred the French Network of Human Spongiform Encephalopathies as having suspected CJD. In a series 465 autopsied cases, ranked second among degenerative alternative diagnoses analyzed factors that contributed misleading diagnosis, and suggest detection 14-3-3 protein in CSF useful distinguish CJD DLB.
Repair of cytotoxic DNA damage by O6-methylguanine-DNA methyltransferase (MGMT) is a potentially important factor chemoresistance to chloroethylnitrosoureas (CENUs), commonly used in the treatment glioblastoma multiforme (GBM). The value p53 as prognostic GBMs remains unclear, but possible relationship between MGMT gene expression and has been suggested. To further examine these GBM characteristics vivo, we assessed using semi-quantitative RT-PCR alteration immuno-histochemistry on series 39...
Human prion diseases are a heterogeneous group of fatal neurodegenerative disorders, characterized by the deposition partially protease-resistant protein (PrPres), astrocytosis, neuronal loss and spongiform change in brain. Among inherited forms that represent 15% patients, different phenotypes have been described depending on variations detected at positions within gene. Here, we report new mechanism governing phenotypic variability diseases. First, observed substitution residue 211 with...
Radiotherapy is an essential component of glioma standard treatment. Glioblastomas (GBM), however, display important radioresistance leading to tumor recurrence. To improve patient prognosis, there a need radiosensitize GBM cells and circumvent the mechanisms resistance caused by interactions between their microenvironment. STAT3 has been identified as therapeutic target in because its involvement sustaining escape both treatment immune control. Here, we studied role activation on tyrosine...
Neuroepithelial papillary tumor of the pineal region (PTPR) has been defined as a distinct entity that is increasingly being recognized, with 96 cases now reported. This shares morphologic features both ependymomas and choroid plexus tumors. PTPR characterized by an epithelial-like growth pattern in which vessels are covered layers cells forming perivascular pseudorosettes. These tumors exhibit various combinations solid architecture, making differential diagnosis difficult to establish. We...
Benign prostatic hyperplasia is a nonmalignant enlargement of the prostate that commonly occurs in older men. We show liver X receptor (Lxr)-α knockout mice (lxrα−/−) develop ventral hypertrophy, correlating with an overaccumulation secreted proteins ducts and alteration vesicular trafficking epithelial cells. In fluid lxrα−/− prostates, spermine binding protein highly accumulated shows 3000-fold increase its mRNA. This overexpression mediated by androgen hypersensitivity mice, restricted to...
Malignant gliomas are the most common primary brain tumors. Grade III and IV harboring wild-type IDH1/2 aggressive. In addition to surgery radiotherapy, concomitant adjuvant chemotherapy with temozolomide (TMZ) significantly improves overall survival (OS). The methylation status of O 6 -methylguanine-DNA methyltransferase ( MGMT ) promoter is predictive TMZ response a prognostic marker cancer outcome. However, regions which correlates best in aggressive glioma whether value could be refined...